First-generation adenovirus vectors shorten survival time in a murine model of sepsis

Journal of Immunology

Volumn 169, Issue 11, 2002, Pages 6539-6545

  Doerschug, Kevin ^a   Sanlioglu, Salih ^a,b   Flaherty, Dawn M ^a   Wilson, Rebecca L ^a   Yarovinsky, Timur ^a   Monick, Martha M ^a   Engelhardt, John F ^a   Hunninghake, Gary W ^a  

^a UNIVERSITY OF IOWA   (United States)

^b AKDENIZ UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALANINE AMINOTRANSFERASE; BETA GALACTOSIDASE; GREEN FLUORESCENT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOSAFETY; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNOCYTOCHEMISTRY; KUPFFER CELL; LIVER CELL DAMAGE; LUNG INJURY; LYMPHOCYTE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SERUM; SPLEEN CELL; SURVIVAL TIME; THYMOCYTE; VIRAL GENE THERAPY; ADENOVIRUS; ANIMAL; BACTERIAL COUNT; C57BL MOUSE; GENE THERAPY; GENE VECTOR; GENETICS; IMMUNOLOGY; LIVER; LUNG; METABOLISM; METHODOLOGY; MICROBIOLOGY; PATHOLOGY; SAFETY; SPLEEN; THYMUS;

ADENOVIRIDAE; ANIMALS; COLONY COUNT, MICROBIAL; FEMALE; GENE THERAPY; GENETIC VECTORS; KUPFFER CELLS; LIVER; LUNG; LYMPHOCYTES; MICE; MICE, INBRED C57BL; SAFETY; SEPSIS; SPLEEN; THYMUS GLAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036885016     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.11.6539     Document Type: Article

References (47)

1. Wilson, J. M. 2001. Adenovirus-mediated gene transfer to liver. Adv. Drug Deliv. Rev. 46:205.
2. 121 improves lower-extremity endothelial function and flow reserve. Circulation 104:753.
3. Minter, R. M., M. A. Ferry, M. E. Murday, C. L. Tannahill, F. R. Bahjat, C. Oberholzer, A. Oberholzer, D. LaFace, B. Hutchins, S. Wen, et al. 2001. Adenoviral delivery of human and viral IL-10 in murine sepsis. J. Immunol. 167:1053.
4. Oberholzer, C., A. Oberholzer, F. R. Bahjat, R. M. Minter, C. L. Tannahill, A. Abouhamze, D. LaFace, B. Hutchins, M. J. Clare-Salzler, and L. L. Moldawer. 2001. Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis. Proc. Natl. Acad. Sci. USA 98:11503.
5. Kolls, J. K., D. Lei, S. Nelson, W. R. Summer, S. Greenberg, and B. Beutler. 1995. Adenovirus-mediated blockade of tumor necrosis factor in mice protects against endotoxic shock yet impairs pulmonary host defense. J. Infect. Dis. 171:570.
6. Drazan, K. E., L. Wu, D. Bullington, and A. Shaked. 1996. Viral IL-10 gene therapy inhibits TNF-α and IL-1β, not IL-6, in the newbom endotoxemic mouse. J Pediatr. Surg. 31:411.
7. Fink, M. P., and S. O. Heard. 1990. Laboratory models of sepsis and septic shock. J. Surg. Res. 49:186.
8. Zwacka, R. M., W. Zhou, Y. Zhang, C. J. Darby, L. Dudus, J. Halldorson, L. Oberley, and J. F. Engelhardt. 1998. Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation. Nat. Med. 4:698.
9. Engelhardt, J. F., Y. Yang, L. D. Stratford-Perricaudet, E. D. Allen, K. Kozarsky, M. Perricaudet, J. R. Yankaskas, and J. M. Wilson. 1993. Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. Nat. Genet. 4:27.
10. Engelhardt, J. F., X. Ye, B. Doranz, and J. M. Wilson. 1994. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. USA 91:6196.
11. Walley, K. R., N. W. Lukacs, T. J. Standiford, R. M. Strieter, and S. L. Kunkel. 1996. Balance of inflammatory cytokines related to severity and mortality of murine sepsis. Infect. Immun. 64:4733.
12. Zhou, W., Y. Zhang, M. S. Hosch, A. Lang, R. M. Zwacka, and J. F. Engelhardt. 2001. Subcellular site of superoxide dismutase expression differentially controls AP-1 activity and injury in mouse liver following ischemia/reperfusion. Hepatology 33:902.
13. Ayala, A., T. A. Evans, and I. H. Chaudry. 1998. Does hepatocellular injury in sepsis involve apoptosis? J. Surg. Res. 76:165.
14. Weiss, Y. G., L. Bellin, P. K. Kim, K. M. Andrejko, C. A. Haaxma, N. Raj, E. E. Furth, and C. S. Deutschman. 2001. Compensatory hepatic regeneration after mild, but not fulminant, intraperitoneal sepsis in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 280:G968.
15. Bone, R. C. 1991. Gram-negative sepsis: background, clinical features, and intervention. Chest 100:802.
16. Viget, N. B., B. P. Guery, F. Ader, R. Neviere, S. Alfandari, C. Creuzy, M. Roussel-Delvallez, C. Foucher, C. M. Mason, G. Beaucaire, and J. F. Pittet. 2000. Keratinocyte growth factor protects against Pseudomonas aeruginosa-induced lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 279:L1199.
17. Oberholzer, C., A. Oberholzer, M. Clare-Salzler, and L. L. Moldawer. 2001. Apoptosis in sepsis: a new target for therapeutic exploration. FASEB J. 15:879.
18. + T lymphocytes in humans. J. Immunol. 166:6952.
19. Ayala, A., C. S. Chung, G. Y. Song, and I. H. Chaudry. 2001. IL-10 mediation of activation-induced TH1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis. Cytokine 14:37.
20. Martin, C., C. Boisson, M. Haccoun, L. Thomachot, and J. L. Mege. 1997. Patterns of cytokine evolution (tumor necrosis factor-α and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit. Care Med. 25:1813.
21. Burdon, D., T. Tiedje, K. Pfeffer, E. Vollmer, and P. Zabel. 2000. The role of tumor necrosis factor in the development of multiple organ failure in a murine model. Crit. Care Med. 28:1962.
22. Remick, D. G., D. E. Newcomb, G. L. Bolgos, and D. R. Call. 2000. Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs cecal ligation and puncture. Shock 13:110.
23. Ebong, S., D. Call, J. Nemzek, G. Bolgos, D. Newcomb, and D. Remick. 1999. Immunopathologic alterations in murine models of sepsis of increasing severity. Infect. Immun. 67:6603.
24. Otero-Anton, E., A. Gonzalez-Quintela, A. Lopez-Soto, S. Lopez-Ben, J. Llovo, and L. F. Perez. 2001. Cecal ligation and puncture as a model of sepsis in the rat: influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor a levels. Eur. Surg. Res. 33:77.
25. Neilson, D., J. P. Kavanagh, and P. N. Rao. 1996. Kinetics of circulating TNF-α and TNF soluble receptors following surgery in a clinical model of sepsis. Cytokine 8:938.
26. van der Poll, T., and S. J. van Deventer. 1999. Cytokines and anticytokines in the pathogenesis of sepsis. Infect. Dis. Clin. North Am. 13:413.
27. Baechtold, F., J. A. Scott, M. Markert, S. Mehta, D. G. McCormack, F. Anglada, D. Galaud, M. Vaglio, B. Waeber, and F. Feihl. 2001. Does the activation of poly(ADP-ribose) synthetase mediate tissue injury in the sepsis induced by cecal ligation and puncture? Shock 16:137.
28. Akunda, J. K., F. A. Ahrens, and T. T. Kramer. 2001. Evaluation of phagocytosis, bactericidal activity, and production of superoxide anion, nitric oxide, and tumor necrosis factor-α in Kupffer cells of neonatal pigs. Am. J. Vet. Res. 62:1040.
29. Hume, D. A., V. H. Perry, and S. Gordon. 1984. The mononuclear phagocyte system of the mouse defined by immunohistochemical localisation of antigen F4/80: macrophages associated with epithelia. Anal. Rec. 210:503.
30. Van Zee, K. J., T. Kohno, E. Fischer, C. S. Rock, L. L. Moldawer, and S. F. Lowry. 1992. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor α in vitro and in vivo. Proc. Natl. Acad. Sci. USA 89:4845.
31. van der Poll, T., and S. F. Lowry. 1995. Tumor necrosis factor in sepsis: mediator of multiple organ failure or essential part of host defense? Shock 3:1.
32. Echtenacher, B., K. Weigl, N. Lehn, and D. N. Mannel. 2001. Tumor necrosis factor-dependent adhesions as a major protective mechanism early in septic peritonitis in mice. Infect. Immun. 69:3550.
33. Temkin, V., and F. Levi-Schaffer. 2001. Mechanism of tumour necrosis factor α mediated eosinophil survival. Cytokine 15:20.
34. , Xuan, D., D. P. Nicolau, C. H. Nightingale, and R. Quintiliani. 2001. Circulating tumor necrosis factor-α production during the progression of rat endotoxic sepsis. Chemotherapy 47:194.
35. McGuire, S. O., Z. D. Ling, J. W. Lipton, C. E. Sortwell, T. J. Collier, and P. M. Carvey. 2001. Tumor necrosis factor α is toxic to embryonic mesencephalic dopamine neurons. Exp. Neurol. 169:219.
36. Douzinas, E. E., P. D. Tsidemiadou, M. T. Pitaridis, I. Andrianakis, A. Bobota-Chloraki, K. Katsouyanni, D. Sfyras, K. Malagari, and C. Roussos. 1997. The regional production of cytokines and lactate in sepsis-related multiple organ failure. Am. J. Respir. Crit. Care Med. 155:53.
37. Echtenacher, B., D. N. Mannel, and L. Hultner. 1996. Critical protective role of mast cells in a model of acute septic peritonitis. Nature 381:75.
38. Minter, R. M., J. E. Rectenwald, K. Fukuzuka, C. L. Tannahill, D. La Face, V. Tsai, I. Ahmed, E. Hutchins, R. Moyer, E. M. Copeland, 3rd, and L. L. Moldawer. 2000. TNF-α receptor signaling and IL-10 gene therapy regulate the innate and humoral immune responses to recombinant adenovirus in the lung. J. Immunol. 164:443.
39. Mountain, A. 2000. Gene therapy: the first decade. Trends Biotechnol. 18:119.
40. Redl, H., G. Schlag, E. Paul, S. Bahrami, W. A. Buurman, R. M. Strieter, S. L. Kunkel, J. Davies, and R. Foulkes. 1996. Endogenous modulators of TNF and IL-1 response are under partial control of TNF in baboon bacteremia. Am. J. Physiol. 271:R1193.
41. Bone, R. C. 1991. The pathogenesis of sepsis. Ann. Intern. Med. 115:457.
42. Partrick, D. A., E. E. Moore, F. A. Moore, W. L. Biffl, and C. C. Barnett, Jr. 1999. Release of anti-inflammatory mediators after major torso trauma correlates with the development of postinjury multiple organ failure. Am. J. Surg. 178:564.
43. Schroder, J., F. Stuber, H. Gallati, F. U. Schade, and B. Kremer. 1995. Pattern of soluble TNF receptors I and II in sepsis. Infection 23:143.
44. Zhang, H. G., T. Zhou, P. Yang, C. K. Edwards, 3rd, D. T. Curiel, and J. D. Mountz. 1998. Inhibition of tumor necrosis factor α decreases inflammation and prolongs adenovirus gene expression in lung and liver. Hum. Gene Ther. 9:1875.
45. Casey, L. C. 2000. Immunologic response to infection and its role in septic shock. Crit. Care Clin. 16:193.
46. Opal, S. M., A. S. Cross, J. W. Jhung, L. D. Young, J. E. Palardy, N. A. Parejo, and C. Donsky. 1996. Potential hazards of combination immunotherapy in the treatment of experimental septic shock. J. Infect. Dis. 173:1415.
47. Rothe, J., W. Lesslauer, H. Lotscher, Y. Lang, P. Koebel, F. Kontgen, A. Althage, R. Zinkemagel, M. Steinmetz, and H. Bluethmann. 1993. Mice lacking the tumour necrosis factor receptor I are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364:798.