Mechanism of the specific neuronal toxicity of a type I ribosome-inactivating protein, trichosanthin

Neurotoxicity Research

Volumn 18, Issue 2, 2010, Pages 161-172

  Sha, Ou ^a,b   Yew, David Tai Wai ^a   Cho, Eric Yu Pang ^a   Ng, Tzi Bun ^a   Yuan, Lin ^b   Kwong, Wing Hang ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b SHENZHEN UNIVERSITY   (China)

Author keywords

Apoptosis; Necrosis; Ribosome inactivating proteins; Ricin A chain; Trichosanthin

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; GRIFFONIA SIMPLICIFOLIA LECTINS; PLANT LECTIN; RIBOSOME INACTIVATING PROTEIN 1; RICIN; TRICHOSANTHIN;

ANIMAL; APOPTOSIS; ARTICLE; CELL COUNT; COMPARATIVE STUDY; DRUG EFFECT; FEMALE; GLIA; INTRAOCULAR DRUG ADMINISTRATION; METABOLISM; MITOCHONDRION; NERVE CELL; PATHOLOGY; RAT; RETINA; SPRAGUE DAWLEY RAT; STATISTICS; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; CELL COUNT; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; INJECTIONS, INTRAOCULAR; MITOCHONDRIA; NEUROGLIA; NEURONS; PLANT LECTINS; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RIBOSOME INACTIVATING PROTEINS, TYPE 1; RICIN; TRICHOSANTHIN;

EID: 77956661774     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-009-9122-1     Document Type: Article

References (47)

1. Audi J, Belson M, Patel M, Schier J, Osterloh J (2005) Ricin poisoning: a comprehensive review. JAMA 294:2342-2351
2. Battelli MG (2004) Cytotoxicity and toxicity to animals and humans of ribosome-inactivating proteins. Mini Rev Med Chem 4:513-521
3. Bringmann A, Reichenbach A (2001) Role of Müller cells in retinal degenerations. Front Biosci 6:E72-E92
4. Chan WL, Shaw PC, Tam SC, Jacobsen C (2000) Trichosanthin interacts with and enters cells via LDL receptor family members. Biochem Biophys Res Commun 270:453-457
5. Chen TA, Yang F, Cole GM, Chan SO (2001) Inhibition of caspase-3-like activity reduces glutamate induced cell death in adult rat retina. Brain Res 904:177-188
6. Collins EJ, Robertus JD, Lo Presti M, Stone KL, Williams KR, Wu P, Hwang K, Piatak M (1990) Primary amino acid sequence of alpha-trichosanthin and molecular models for abrin A-chain and alpha-trichosanthin. J Biol Chem 265:8665-8669
7. Crane IJ, Wallace CA, McKillop-Smith S, Forrester JV (2000) CXCR4 receptor expression on human retinal pigment epithelial cells from the blood-retinal barrier leads to chemokine secretion and migration in response to stromal cell-derived factor 1 alpha. J Immunol 165:4372-4378
8. Emmanuel F, Turpin E, Alfsen A, Frénoy JP (1988) Separation of ricin A- and B-chains after dithiothreitol reduction. Anal Biochem 173:134-141
9. Foxwell BM, Donovan TA, Thorpe PE, Wilson G (1985) The removal of carbohydrates from ricin with endoglycosidases H, F and D and alpha-mannosidase. Biochim Biophys Acta 840:193-203
10. Frankel AE, Fu T, Burbage C, Tagge E, Harris B, Vesely J, Willingham MC (1997) Lectin-deficient ricin toxin intoxicates cells bearing the D-mannose receptor. Carbohydr Res 300:251-258
11. Girbés T, Ferreras JM, Arias FJ, Stirpe F (2004) Description, distribution, activity and phylogenetic relationship of ribosomeinactivating proteins in plants, fungi and bacteria. Mini Rev Med Chem 4:461-476
12. He L, Poblenz AT, Medrano CJ, Fox DA (2000) Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore. J Biol Chem 275:12175-12184
13. Humphrey MF, Chu Y, Mann K, Rakoczy P (1997) Retinal GFAP and bFGF expression after multiple argon laser photocoagulation injuries assessed by both immunoreactivity and mRNA levels. Exp Eye Res 64:361-369
14. Kroemer G (1999) Mitochondrial control of apoptosis: an overview. Biochem Soc Symp 66:1-15
15. Kubota S, Yeung HW, Yang JT (1987) Conformation similarities of ricin A-chain and trichosanthin. Int J Pept Protein Res 30:646-651
16. Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323-332
17. Li MX, Yeung HW, Pan LP, Chan SI (1991) Trichosanthin, a potent HIV-1 inhibitor, can cleave supercoiled DNA in vitro. Nucleic Acids Res 19:6309-6312
18. Li CM, Yan RT, Wang SZ (2001) Atrophy of Müller glia and photoreceptor cell in chick retina misexpressing cNSCL2. Invest Ophthalmol Vis Sci 42:3103-3109
19. Li F, Mei Y, Wang Y, Chen C, Tu J, Xiao B, Xu L (2005) Trichosanthin inhibits antigen-specific T cell expansion through nitric oxidemediated apoptosis pathway. Cell Immunol 234:23-30
20. Li J, Xia X, Ke Y, Nie H, Smith MA, Zhu X (2007) Trichosanthin induced apoptosis in HL-60 cells via mitochondrial and endoplasmic reticulum stress signaling pathways. Biochim Biophys Acta 1770:1169-1180
21. Linehan SA, Martinez-Pomares L, Da Silva RP, Gordon S (2001) Endogenous ligands of carbohydrate recognition domains of the mannose receptor in murine macrophages, endothelial cells and secretory cells; potential relevance to inflammation and immunity. Eur J Immunol 31:1857-1866
22. Liu GW, Liu FY, Li TJ, Yu SJ (1985) A summary of 402 cases of termination of early pregnancy with crystalline preparation of trichosanthin. In: Chang HM, Yeung HW, Tso WW, Koo A (eds) Advances in Chinese medicinal materials research. World Scientific Publ. Co, Singapore, pp 327-333
23. Liu C, Li Y, Peng M, Laties AM, Wen R (1999) Activation of caspase-3 in the retinal of transgenic rats with the rhodopsin mutation s334ter during photoreceptor degeneration. J Neurosci 19:4778-4785
24. Maraganore JM, Joseph M, Bailey MC (1987) Purification and characterization of trichosanthin. Homology to the ricin A chain and implications as to mechanism of abortifacient activity. J Biol Chem 262:11628-11633
25. Muramoto K, Kamiya H, Kawauchi H (1984) The application of fluorescein isothiocyanate and high-performance liquid chromatography for the microsequencing of proteins and peptides. Anal Biochem 141:446-450
26. Nickells RW (1999) Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death. Surv Ophthalmol 43:S151-S161
27. Oppenheim RW (1991) Cell death during development of the nervous system. Annu Rev Neurosci 14:453-501
28. Saude T (1993) Ocular anatomy and physiology. Blackwell Scientific Publ. Co., Harvard, Boston
29. Sha O, Kwong WH, Pang Cho EY, Wai Yew DT, Ng TB (2008) Different neuronal toxicity of single-chain ribosome-inactivating proteins on the rat retina. Toxicon 51:45-53
30. Shaw PC, Lee KM, Wong KB (2005) Recent advances in trichosanthin, a ribosome-inactivating protein with multiple pharmacological properties. Toxicon 45:683-689
31. Shock LP, Bare DJ, Klinz SG, Maness PF (1995) Protein tyrosine phosphatases expressed in developing brain and retinal Müller glia. Brain Res Mol Brain Res 28:110-116
32. Sikriwal D, Ghosh P, Batra JK (2008) Ribosome inactivating protein saporin induces apoptosis through mitochondrial cascade, independent of translation inhibition. Int J Biochem Cell Biol 40:2880-2888
33. Simmons BM, Stahl PD, Russell JH (1986) Mannose receptormediated uptake of ricin toxin and ricin A chain by macrophages. Multiple intracellular pathways for a chain translocation. J Biol Chem 261:7912-7920
34. Singh M, Savitz SI, Hoque R, Gupta G, Roth S, Rosenbaum PS, Rosenbaum DM (2001) Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia. J Neurochem 72:466-475
35. Stirpe F, Battelli MG (2006) Ribosome-inactivating proteins: progress and problems. Cell Mol Life Sci 63:1850-1866
36. Tam P P L, Chan YW, Yeung HW (1984) Effects of two forms of momorcharins and alpha-trichosanthin on early pregnancy in the mouse. In: Programme and Abstracts, International Symposium Medicinal Material Research (Abstracts No. 19), 24 pp
37. Wang P, Li JC (2007) Trichosanthin-induced specific changes of cytoskeleton configuration were associated with the decreased expression level of actin and tubulin genes in apoptotic Hela cells. Life Sci 81:1130-1140
38. Wang YY, Ouyang DY, Huang H, Chan H, Tam SC, Zheng YT (2005) Enhanced apoptotic action of trichosanthin in HIV-1 infected cells. Biochem Biophys Res Commun 331:1075-1080
39. Wang P, Yan H, Li JC (2007) CREB-mediated Bcl-2 expression in trichosanthin-induced Hela cell apoptosis. Biochem Biophys Res Commun 363:101-105
40. Wolozin B, Behl C (2000) Mechanisms of neurodegenerative disorders: Parts 2: control of cell death. Arch Neurol 57:801-804
41. Xu YZ, Liu WY (2000) Effects of the active aldehyde group generated by RNA N-glycosidase in the sarcin/ricin domain of rat 28S ribosomal RNA on peptide elongation. Biol Chem 381:113-119
42. Yeung HW, Poon SP, Ng TB, Li WW (1987) Isolation and characterization of an immunosuppressive protein from Trichosanthes kirilowii root tubers. Immunopharmacol Immunotoxicol 9:25-46
43. Zenilman ME, Fiani M, Stahl P, Brunt E, Flye MW (1988) Use of ricin A-chain to selectively deplete Kupffer cells. J Surg Res 45:82-89
44. Zhang JS, Liu WY (1992) The mechanism of action of trichosanthin on eukaryotic ribosomes-RNA N-glycosidase activity of the cytotoxin. Nucleic Acids Res 20:1271-1275
45. Zhang C, Gong Y, Ma H, An C, Chen D (2001) Reactive oxygen species involved in trichosanthin-induced apoptosis of human choriocarcinoma cells. Biochem J 355:653-661
46. Zhao J, Ben LH, Wu YL, Hu W, Ling K, Xin SM, Nie HL, Ma L, Pei G (1999) Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors. J Exp Med 190:101-111
47. Zheng G, Bachinsky DR, Stamenkovic I, Strickland DK, Brown D, Andres G, McCluskey RT (1994) Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpa 2MR, and the receptor-associated protein (RAP). J Histochem Cytochem 42:531-542