Toosendanin inhibits hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis

Planta Medica

Volumn 76, Issue 13, 2010, Pages 1447-1453

  He, Yujuan ^a   Wang, Jin ^a   Liu, Xiaoling ^a   Zhang, Ling ^a   Yi, Gang ^a   Li, Chenwei ^a   He, Xiao ^a   Wang, Peng ^a   Jiang, Hui ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

anticancer effects; apoptosis; hepatocellular carcinoma; Melia toosendan Sieb. et Zucc.; Meliaceae; toosendanin

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYCLOPHOSPHAMIDE; FAS ANTIGEN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; TOOSENDANIN; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; DRUG MEGADOSE; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; LOW DRUG DOSE; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; ANTIGENS, CD95; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; MALE; MELIA; MICE; MICE, INBRED BALB C; MITOCHONDRIA; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

MELIA TOOSENDAN; MELIACEAE; MUS;

EID: 77956661431     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1240902     Document Type: Article

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