Dietary fish oil n-3 polyunsaturated fatty acids and alpha-linolenic acid differently affect brain accretion of docosahexaenoic acid and expression of desaturases and sterol regulatory element-binding protein 1 in mice

Journal of Nutritional Biochemistry

Volumn 21, Issue 10, 2010, Pages 954-960

  Zhu, Haiyan ^a   Fan, Chaonan ^a   Xu, Feng ^a   Tian, Chunyu ^a   Zhang, Feng ^a   Qi, Kemin ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Brain; Desaturase; Mice; N 3 polyunsaturated fatty acids; Sterol regulatory element binding protein

Indexed keywords

DOCOSAHEXAENOIC ACID; FISH OIL; LINOLENIC ACID; LINOLEOYL COENZYME A DESATURASE; LINSEED OIL; OMEGA 3 FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BRAIN LEVEL; CONTROLLED STUDY; DIETARY INTAKE; DOWN REGULATION; FATTY ACID ANALYSIS; FEMALE; LIPID COMPOSITION; LIVER LEVEL; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ALPHA-LINOLENIC ACID; ANIMALS; BASE SEQUENCE; BRAIN; DIETARY FATS, UNSATURATED; DNA PRIMERS; DOCOSAHEXAENOIC ACIDS; FATTY ACID DESATURASES; FATTY ACIDS, OMEGA-3; FISH OILS; LIVER; MICE; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

MUS;

EID: 77956651435     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.07.011     Document Type: Article

References (52)

1. Innis S.M. Dietary (n-3) fatty acids and brain development. J Nutr 2007, 137:855-859.
2. Mccann J.C., Ames B.N. Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr 2005, 82:281-295.
3. Kawakita E., Hashimoto M., Shido O. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience 2006, 139:991-997.
4. Assisi A., Banzi R., Buonocore C., Capasso F., Di Muzio V., Michelacci F., et al. Fish oil and mental health: the role of n-3 long-chain polyunsaturated fatty acids in cognitive development and neurological disorders. Int Clin Psychopharmacol 2006, 21:319-336.
5. Burdge G.C., Calder P.C. Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev 2005, 45:581-597.
6. Seo T., Blaner W.S., Deckelbaum R.J. Omega-3 fatty acids: molecular approaches to optimal biological outcomes. Curr Opin Lipidol 2005, 16:11-18.
7. Yehuda S., Rabinovitz S., Mostofsky D.I. Essential fatty acids are mediators of brain biochemistry and cognitive functions. J Neurosci Res 1999, 56:565-570.
8. Qi K., Hall M., Deckelbaum R.J. Long-chain polyunsaturated fatty acid accretion in brain. Curr Opin Clin Nutr Metab Care 2002, 5(2):133-138.
9. Lefkowitz W., Lim S.Y., Lin Y., Salem N. Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid, and body stores in the developing rat. Pediatr Res 2005, 57:157-165.
10. Igarashi M., DeMar J.C., Ma K., Chang L., Bell J.M., Rapoport S.I. Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation. J Lipid Res 2007, 48:1150-1158.
11. Igarashi M., DeMar J.C., Ma K., Chang L., Bell J.M., Rapoport S.I. Upregulated liver conversion of alpha-linolenic acid to docosahexaenoic acid in rats on a 15 week n-3 PUFA-deficient diet. J Lipid Res 2007, 48:152-164.
12. Connor W.E., Neuringer M., Reisbick S. Essential fatty acids: the importance of n-3 fatty acids in the retina and brain. Nutr Rev 1992, 50:21-29.
13. Simopoulos A.P. Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed Pharmacother 2006, 60:502-507.
14. Gibbons A. Humans' head start: new views of brain evolution. Science 2002, 296:836-837.
15. Cho H.P., Nakamura M.T., Clarke S.D. Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. J Biol Chem 1999, 274:471-477.
16. Cho H.P., Nakamura M., Clarke S.D. Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. J Biol Chem 1999, 274:37335-37339.
17. Nakamura M.T., Nara T.Y. Essential fatty acid synthesis and its regulation in mammals. Prostaglandins Leukot Essent Fatty Acids 2003, 68:145-150.
18. Matsuzaka T., Shimano H., Yahagi N., Amemiya-Kudo M., Yoshikawa T., Hasty A.H., et al. Dual regulation of mouse Delta (5)- and Delta (6)-desaturase gene expression by SREBP-1 and PPARalpha. J Lipid Res 2002, 43:107-114.
19. Xu J., Nakamura M.T., Cho H.P., Clarke S.D. Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J Biol Chem 1999, 274:23577-23583.
20. Nakatani T., Kim H.J., Kaburagi Y., Yasuda K., Ezaki O. A low fish oil inhibits SREBP-1 proteolytic cascade, while a high-fish-oil feeding decreases SREBP-1 mRNA in mice liver: relationship to anti-obesity. J Lipid Res 2003, 44:369-379.
21. Houseknecht K.L., Cole B.M., Steele P.J. Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: a review. Domest Anim Endocrinol 2002, 22:1-23.
22. Lepage G., Roy C.C. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 1986, 27:114-120.
23. Rodríguez-Palmero M., Lopez-Sabater M.C., Castellote-Bargallo A.I., De la Torre-Boronat M.C., Rivero-Urgell M. Comparison of two methods for the determination of fatty acid profiles in plasma and erythrocytes. J Chromatogr A 1997, 778:435-439.
24. Whelan J.A., Russell N.B., Whelan M.A. A method for the absolute quantification of cDNA using real-time PCR. J Immunol Methods 2003, 278:261-269.
25. Lawler J.F., Yin M., Diehl A.M., Roberts E., Chatterjee S. Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. J Biol Chem 1998, 273:5053-5059. Related articles, links.
26. Bernoud N., Fenart E., Bénistant C., Pageaux J.F., Dehouck M.P., Molière P., et al. Astrocytes are mainly responsible for the polyunsaturated fatty acid enrichment in blood-brain barrier endothelial cells in vitro. J Lipid Res 1998, 39:1816-1824.
27. Kim H.Y. Novel metabolism of docosahexaenoic acid in neural cells. J Biol Chem 2007, 282:18661-18665.
28. Ozias M.K., Carlson S.E., Levant B. Maternal parity and diet (n-3) polyunsaturated fatty acid concentration influence accretion of brain phospholipid docosahexaenoic acid in developing rats. J Nutr 2007, 137:125-129.
29. Diau G.Y., Hsieh A.T., Sarkadi-Nagy E.A., Wijendran V., Nathanielsz P.W., Brenna J.T. The influence of long-chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system. BMC Med 2005, 3:11.
30. Anderson G.J., Neuringer M., Lin D.S., Connor W.E. Can prenatal n-3 fatty acid deficiency be completely reversed after birth? Effects on retinal and brain biochemistry and visual function in rhesus monkeys. Pediatr Res 2005, 58:865-872.
31. Rapoport S.I., Rao J.S., Igarashi M. Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostaglandins Leukot Essent Fatty Acids 2007, 77:251-261.
32. Bowen R.A., Clandinin M.T. Maternal dietary 22:6n-3 is more effective than 18:3n-3 in increasing the 22:6n-3 content in phospholipids of glial cells from neonatal rat brain. Br J Nutr 2005, 93:601-611.
33. Anderson G.J., Tso P.S., Connor W.E. Incorporation of chylomicron fatty acids into the developing rat brain. J Clin Invest 1994, 93:2764-2767.
34. Dinh T.K., Bourre J.M., Durand G. Effect of age and alpha-linolenic acid deficiency on delta 6 desaturase activity and liver lipids in rats. Lipids 1993, 28:517-523.
35. Garg M.L., Thomson A.B., Clandinin M.T. Effect of dietary cholesterol and/or omega 3 fatty acids on lipid composition and delta 5-desaturase activity of rat liver microsomes. J Nutr 1988, 118:661-668.
36. Garg M.L., Sebokova E., Thomson A.B., Clandinin M.T. Delta 6-desaturase activity in liver microsomes of rats fed diets enriched with cholesterol and/or omega 3 fatty acids. Biochem J 1988, 249:351-356.
37. Peluffo R.O., Nervi A.M., Brenner R.R. Linoleic acid desaturation activity of liver microsomes of essential fatty acid deficient and sufficient rats. Biochim Biophys Acta 1976, 441:25-31.
38. Bernert J.T., Sprecher H. Studies to determine the role rates of chain elongation and desaturation play in regulating the unsaturated fatty acid composition of rat liver lipids. Biochim Biophys Acta 1975, 398:354-363.
39. Igarashi M., Ma K., Chang L., Bell J.M., Rapoport S.I. Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain. J Lipid Res 2007, 48:2463-2470.
40. Demar J.C., Ma K., Chang L., Bell J.M., Rapoport S.I. alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. J Neurochem 2005, 94(4):1063-1076.
41. Wang Y., Botolin D., Christian B., Busik J., Xu J., Jump D.B. Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases. J Lipid Res 2005, 46:706-715.
42. Wang Y., Torres-Gonzalez M., Tripathy S., Botolin D., Christian B., Jump D.B. Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition. J Lipid Res 2008, 49:1538-1552.
43. Okamoto K., Kakuma T., Fukuchi S., Masaki T., Sakata T., Yoshimatsu H. Sterol regulatory element binding protein (SREBP)-1 expression in brain is affected by age but not by hormones or metabolic changes. Brain Res 2006, 1081:19-27.
44. Jump D.B. The biochemistry of n-3 polyunsaturated fatty acids. J Biol Chem 2002, 277(11):8755-8758.
45. Botolin D., Wang Y., Christian B., Jump D.B. Docosahexaenoic acid (22:6n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways. J Lipid Res 2006, 47:181-192.
46. Xu J., Teran-Garcia M., Park J.H., Nakamura M.T., Clarke S.D. Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay. J Biol Chem 2001, 276:9800-9807.
47. Heneka M.T., Landreth G.E. PPARs in the brain. Biochim Biophys Acta 2007, 1771:1031-1045.
48. Braissant O., Foufelle F., Scotto C., Dauça M., Wahli W. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 1996, 137:354-366.
49. Braissant O., Wahli W. Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development. Endocrinology 1998, 139:2748-2754.
50. Tang C., Cho H.P., Nakamura M.T., Clarke S.D. Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element. J Lipid Res 2003, 44:686-695.
51. Kris-Etherton P.M., Taylor D.S., Yu-Poth S., Huth P., Moriarty K., Fishell V., et al. Polyunsaturated fatty acids in the food chain in the United States. Am J Clin Nutr 2000, 71:179S-188S.
52. Feskens E.J., Kromhout D. Epidemiologic studies on Eskimos and fish intake. Ann N Y Acad Sci 1993, 683:9-15.