Can prenatal N-3 fatty acid deficiency be completely reversed after birth? Effects on retinal and brain biochemistry and visual function in rhesus monkeys

Pediatric Research

Volumn 58, Issue 5, 2005, Pages 865-872

  Anderson, Gregory J ^a   Neuringer, Martha ^a,b   Lin, Don S ^a   Connor, William E ^a,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; LINOLENIC ACID; OMEGA 3 FATTY ACID; PHOSPHOLIPID;

A WAVE; AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BRAIN BIOPSY; BRAIN CELL; CONTROLLED STUDY; ELECTRORETINOGRAM; ERYTHROCYTE LEVEL; ESSENTIAL FATTY ACID DEFICIENCY; FATTY ACID BLOOD LEVEL; FEMALE; LIPID COMPOSITION; NEUROCHEMISTRY; NONHUMAN; PHOSPHOLIPID METABOLISM; PREFRONTAL CORTEX; PRENATAL DISORDER; PRIORITY JOURNAL; RETINA CELL; RETINA CONE; RETINA DISEASE; RETINA ROD; RHESUS MONKEY; TISSUE DISTRIBUTION; VISION; VISUAL ACUITY; VISUAL THRESHOLD;

EID: 27144506172     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000182188.31596.5a     Document Type: Article

References (41)

1. Fliesler SJ, Anderson RE 1983 Chemistry and metabolism of lipids in the vertebrate retina. Prog Lipid Res 22:79-131
2. Pawlosky RJ, Denkins Y, Ward G, Salem N Jr 1997 Retinal and brain accretion of long-chain polyunsaturated fatty acids in developing felines: The effects of corn oil-based maternal diets. Am J Clin Nutr 65:465-472
3. Neuringer M, Anderson GJ, Connor WE 1988 The essentiality of n-3 fatty acids for the development and function of the retina and brain. Annu Rev Nutr 8:517-541
4. Benolken RM, Anderson RE, Wheeler TG 1973 Membrane fatty acids associated with the electrical response in visual excitation. Science 182:1253-1254
5. Neuringer M, Connor WE, Van Petten C, Barstad L 1984 Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. J Clin Invest 73:272-276
6. Neuringer M, Connor WE, Lin DS, Barstad L, Luck S 1986 Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci U S A 83:4021-4025
7. Neuringer M 2000 Infant vision and retinal function in studies of dietary long-chain polyunsaturated fatty acids: methods, results, and implications. Am J Clin Nutr 71:256S-267S
8. SanGiovanni JP, ParraCabrera S, Colditz GA, Berkey CS, Dwyer JT 2000 Meta-analysis of dietary essential fatty acids and long- chain polyunsaturated fatty acids as they relate to visual resolution acuity in healthy preterm infants. Pediatrics 105:1292-1298
9. O'Connor DL, Hall R, Adamkin D, Auestad N, Castillo M, Connor WE, Connor SL, Fitzgerald K, Groh-Wargo S, Hartmann EE, Jacobs J, Janowsky J, Lucas A, Margeson D, Mena P, Neuringer M, Nesin M, Singer L, Stephenson T, Szabo J, Zemon V; Ross Preterm Lipid Study 2001 Growth and development in preterm infants fed long-chain polyunsaturated fatty acids: a prospective, randomized controlled trial. Pediatrics 108:359-371
10. Reisbick S, Neuringer M, Hasnain R, Connor WE 1990 Polydipsia in rhesus monkeys deficient in omega-3 fatty acids. Physiol Behav 47:315-323
11. Lin DS, Connor WE, Anderson GJ, Neuringer M 1990 Effects of dietary n-3 fatty acids on the phospholipid molecular species of monkey brain. J Neurochem 55:1200-1207
12. Lin DS, Anderson GJ, Connor WE, Neuringer M 1994 Effect of dietary n-3 fatty acids upon the phospholipid molecular species of the monkey retina. Invest Ophthalmol Vis Sci 35:794-803
13. Teller DY, Morse R, Borton R, Regal D 1974 Visual acuity for vertical and diagonal gratings in human infants. Vision Res 13:1433-1439
14. Connor WE, Neuringer M, Lin DS 1990 Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys. J Lipid Res 31:237-247
15. Bligh EG, Dyer WJ 1959 A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917
16. Rose HG, Oklander M 1965 Improved procedure for the extraction of lipids from human erythrocytes. J Lipid Res 6:428-431
17. Folch J, Lees M, Sloane-Stanley GH 1957 A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509
18. Morrison WR, Smith LM 1964 Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J Lipid Res 5:600-608
19. Winer BJ 1971 Statistical Principles in Experimental Design. McGraw-Hill, New York, pp 445-449
20. Miller RG 1966 Simultaneous Statistical Inference. McGraw-Hill, New York, pp 5-11
21. Neuringer M, Connor WE, Lin DS, Anderson GJ, Barstad L 1991 Dietary omega-3 fatty acids: effects on retinal lipid composition and function in primates. In: Anderson RE, Hollyfield JG, LaVail MM (eds) Retinal Degenerations. CRC Press, New York, pp 117-129
22. Fernstrom JD 1999 Effects of dietary polyunsaturated fatty acids on neuronal function. Lipids 34:161-169
23. Jeffrey BG, Weisinger HS, Neuringer M, Mitchell DC 2001 The role of docosahexaenoic acid in retinal function. Lipids 36:859-871
24. Niu SL, Mitchell DC, Lim SY, Wen ZM, Kim HY, Salem N Jr, Litman BJ 2004 Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency. J Biol Chem 279:31098-31104
25. Innis SM 2000 Essential fatty acids in infant nutrition: lessons and limitations from animal studies in relation to studies on infant fatty acid requirements. Am J Clin Nutr 71:238S-244S
26. Uauy R, Hoffman DR, Mena P, Llanos A, Birch EE 2003 Term infant studies of DHA and ARA supplementation on neurodevelopment: results of randomized controlled trials. J Pediatr 143:S17-S25
27. Jeffrey BG, Mitchell DC, Gibson RA, Neuringer M 2002 n-3 fatty acid deficiency alters recovery of the rod photoresponse in rhesus monkeys. Invest Ophthalmol Vis Sci 43:2806-2814
28. Birch DG, Birch EE, Hoffman DR, Uauy RD 1992 Retinal development in very-low-birth-weight infants fed diets differing in omega-3 fatty acids. Invest Ophthalmol Vis Sci 33:2365-2376
29. Malcolm CA, Hamilton R, McCulloch DL, Montgomery C, Weaver LT 2003 Scotopic electroretinogram in term infants born of mothers supplemented with docosahexaenoic acid during pregnancy. Invest Ophthalmol Vis Sci 44:3685-3691
30. Anderson GJ, Connor WE, Corliss JD 1990 Docosahexaenoic acid is the preferred dietary n-3 fatty acid for the development of the brain and retina. Pediatr Res 27:89-97
31. Sanders TA, Younger KM 1981 The effect of dietary supplements of omega 3 polyunsaturated fatty acids on the fatty acid composition of platelets and plasma choline phosphoglycerides. Br J Nutr 45:613-616
32. Pawlosky RJ, Hibbeln JR, Novotny JA, Salem N Jr 2001 Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res 42:1257-1265
33. Francois CA, Connor SL, Wander RC, Connor WE 1998 Acute effects of dietary fatty acids on the fatty acids of human milk. Am J Clin Nutr 67:301-308
34. Weisinger HS, Vingrys AJ, Bui BV, Sinclair AJ 1999 Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. Invest Ophthalmol Vis Sci 40:327-338
35. Armitage JA, Pearce AD, Sinclair AJ, Vingrys AJ, Weisinger RS, Weisinger HS 2003 Increased blood pressure later in life may be associated with perinatal n-3 fatty acid deficiency. Lipids 38:459-464
36. Bourre JM, Durand G, Pascal G, Youyou A 1989 Brain cell and tissue recovery in rats made deficient in n-3 fatty acids by alteration of dietary fat. J Nutr 119:15-22
37. Carrie I, Clement M, de Javel D, Frances H, Bourre JM 2000 Phospholipid supplementation reverses behavioral and biochemical alterations induced by n-3 polyunsaturated fatty acid deficiency in mice. J Lipid Res 41:473-480
38. Moriguchi T, Loewke J, Garrison M, Catalan JN, Salem N Jr 2001 Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. J Lipid Res 42:419-427
39. Ikemoto A, Ohishi M, Sato Y, Hata N, Misawa Y, Fujii Y, Okuyama H 2001 Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor. J Lipid Res 42:1655-1663
40. Birch EE, Hoffman DR, Uauy R, Birch DG, Prestidge C 1998 Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. Pediatr Res 44:201-209
41. Birch EE, Garfield S, Hoffman DR, Uauy R, Birch DG 2000 A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol 42:174-181