dGirdin a new player of Akt/PKB signaling in Drosophila melanogaster

Frontiers in Bioscience

Volumn 15, Issue 3, 2010, Pages 1164-1171

  Yamaguchi, Masamitsu ^a   Suyari, Osamu ^a   Nagai, Rika ^a   Takahashi, Masahide ^b  

^a KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Actin; Akt PKB; Angiogenesis; Cell size control; Drosophila; Girdin; Metastasis; Review

Indexed keywords

DROSOPHILA MELANOGASTER; MAMMALIA;

ACTIN BINDING PROTEIN; CCDC88A PROTEIN, HUMAN; DROSOPHILA PROTEIN; GIRDIN -LIKE PROTEIN, DROSOPHILA; GIRDIN LIKE PROTEIN, DROSOPHILA; PROTEIN KINASE B; SIGNAL PEPTIDE; VESICULAR TRANSPORT PROTEIN;

ANIMAL; DROSOPHILA MELANOGASTER; GENE EXPRESSION PROFILING; GENETICS; HUMAN; METABOLISM; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); REVIEW; SIGNAL TRANSDUCTION; VASCULARIZATION;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION PROFILING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROFILAMENT PROTEINS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; VESICULAR TRANSPORT PROTEINS;

EID: 77956646429     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3668     Document Type: Article

References (55)

1. R. S. S. Fraser, and P. Nurse. Novel cell cycle control of RNA synthesis in yeasts. Nature 27 726-730 (1978). (Pubitemid 8278332)
2. J. Montagne, M. J. Stewart, H. Stocker, E. Hafen, S. C. Kozma, and G. Thomas. Drosophila S6 kinase: a regulator of cell size. Science 285 2126-2129 (1999). (Pubitemid 29451430)
3. D. P. Brazil, J. Park, and B. A. Hemmings. PKB binding proteins: Getting in on the Akt. Cell 111 293-303 (2002). (Pubitemid 35341386)
4. S. R. Datta, A. Brunet, and M. E. Greenberg. Cellular survival: a play in three Akts. Genes Dev. 13 2905-2927 (1999).
5. I. Vivanco, and C. L. Sawyers. The phosphatidylinositol 3-kinase-Akt pathway in human cancer. Nat. Rev. Cancer 2 489-501 (2002). (Pubitemid 37328931)
6. S. Merlot, and R. A. Firtel. Leading the way: directional sensing through phosphatidylinositol 3-kinase and other signaling pathway. J. Cell Sci. 116 3471-3478 (2003). (Pubitemid 37063391)
7. S. R. Datta, H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg. Akt phospholylation of Bad couples survival signals to cell-intrinsic death machinery. Cell 91 231-241 (1997). (Pubitemid 27456390)
8. B. D. Manning, and L. C. Cantley. AKT/PKB signaling:navigating downstream. Cell 129 1261-1274 (2007).
9. A. Enomoto, H. Murakami, N. Asai, N. Morone, T. Watanabe, K. Kawai, Y. Murakumo, J. Usukura, K. Kaibuchi, and M. Takahashi. Akt/PKB regulates actin organization and cell motility via Girdin/APE. Dev. Cell 9 389-402 (2005). (Pubitemid 41235808)
10. A. Puseenam, Y. Yoshioka, R. Nagai, R. Hashimoto, O. Suyari, M. Itoh, A. Enomoto, M. Takahashi, and M. Yamaguchi. A novel Drosophila Girdin-like protein is involved in Akt pathway control of cell size. Exp. Cell Res. 315 3370-3380 (2009).
11. P. Jiang, A. Enomoto, M. Jijiwa, T. Kato, T. Hasegawa, M. Ishida, S. T., N. Asai, Y. Murakumo, and M. Takahashi. An actin-binding protein Girdin regulates the motility of breast cancer cells. Cancer Res. 68 1310-1318 (2008). (Pubitemid 351346837)
12. T. Kitamura, N. Asai, A. Enomoto, K. Maeda, T. Kato, M. Ishida, P. Jiang, T. Watanabe, J. Usukura, T. Kondo, F. Constantini, T. Murohara, and M. Takahashi. Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin. Nature Cell Biol. 10 329-337 (2008). (Pubitemid 351331020)
13. L. Weng, A. Enomoto, M. Ishida-Takagishi, N. Asai, and M. Takahashi. Girdin for migrating cues: roles of the Akt substrate Girdin in cancer progression and angiogenesis. Cancer Sci. in press (2010).
14. M. Anai, N. Shojima, H. Katagiri, T. Ogihara, H. Sakoda, Y. Onishi, H. Ono, M. Fujishiro, Y. Fukushima, and N. Horike. A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. J. Biol. Chem. 280 18525-18535 (2005). (Pubitemid 41389103)
15. H. Le-Niculescu, I. Niesman, T. Fischer, L. DeVries, and M. G. Farquhar. Identification and characterization of GIV, a novel Gα i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles. J. Biol. Chem. 280 22012- 22020 (2005). (Pubitemid 40827855)
16. F. Simpson, S. Martin, T. M. Evans, M. Kerr, D. E. James, R. G. Parton, R. D. Teasdale, and C. Wicking. A novel Hookrelated protein family and the characterization of Hook-related protein 1. Traffic 6 442-458 (2005). (Pubitemid 40740385)
17. G. J. Praefcke, and H. T. McMahon. The dynamin superfamily:universal membrane tubulation and fission molecules? Nat. Rev. Mol. Cell Biol. 5 133-147 (2004). (Pubitemid 38160256)
18. A. Oshita, S. Kishida, H. Kobayashi, T. Michiue, T. Asahara, M. Asashima, and A. Kikuchi. Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway. Genes Cells 8 1005-1017 (2003). (Pubitemid 38072276)
19. N. Hay. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 8 179-183 (2005). (Pubitemid 41317589)
20. C. J. Potter, L. G. Pedraza, and T. Xu. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell. Biol. 4 658-665 (2002). (Pubitemid 34993701)
21. K. M. Hennig, J. Colombani, and T. P. Neufeld. TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth. J. Cell Biol. 173 963-974 (2006).
22. A. L. Edinger, and C. B. Thompson. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol. Biol. Cell 13 2276-2288 (2002). (Pubitemid 34831333)
23. D. C. Fingar, S. Salama, C. Tsou, E. Harlow, and J. Blenis. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 16 1472-1487 (2002). (Pubitemid 34686329)
24. T. Radimerski, J. Montagne, F. Rintelen, H. Stocker, J. van der Kaay, C. P. Downes, E. Hafen, and G. Thomas. dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat. Cell Biol. 4 251-255 (2002). (Pubitemid 34218200)
25. A. Enomoto, N. Asai, T. Namba, Y. Wang, T. Kato, M. Tanaka, H. Tatsumi, S. Taya, D. Tsuboi, K. Kuroda, N. Kaneko, K. Sawamoto, R. Miyamoto, M. Jijiwa, Y. Murakumo, M. Sokabe, T. Seki, K. Kaibuchi, and M. Takahishi. Roles of disrupted-in-schizophrenia 1- interacting protein girdin in postnatal development of the dentate gyrus. Neuron 63 774-787 (2009).
26. J. K. Millar, J. C. Wilson-Annan, S. Anderson, S. Christie, M. S. Tayler, C. A. Semple, R. S. Devon, D. M. St. Clair, W. J. Muir, D. H. Blackwood, and D. J. Porteous. Disruption of two movel genes by a translocation cosegregating with schizophrenia. Hum. Mol. Genet. 9 1415- 1423 (2000). (Pubitemid 30312490)
27. J. Y. Kim, X. Duan, C. Y. Liu, M. H. Jang, J. U. Guo, N. Pow-anpongkul, E. Kang, H. Song, and G. L. Ming. DISC1 regulates new neuron development. Neuron 63 711-713 (2009).
28. C. A. Meyer, H. W. Jacobs, S. A. Datar, W. Du, B. A. Edgar, and C. F. Lehner. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO. J. 19 4533-4542 (2000).
29. J. Luo, B. D. Manning, and L. C. Cantley. Targeting the PI3K-Akt pathway in human cancer: Rational and promise. Cancer Cell 4 257-262 (2003). (Pubitemid 37329790)
30. H. G. Wendel, E. De Stanchina, J. S. Fridman, A. Malina, S. Ray, S. Kogan, C. Cordon-Cardo, J. Pelletier, and S. W. Lowe. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428 267-269 (2004).
31. Y. Samuels, and K. Erickson. Oncogenic PI3K and its role in cancer. Curr. Opin. Oncol. 18 77-82 (2006). (Pubitemid 43740454)
32. B. T. Hennessy, D. L. Smith, P. T. Ram, Y. Lu, and G. B. Mills. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat. Rev. Drug Discov. 4 988-1004 (2005).
33. E. Hernando, E. Charytonowicz, M. E. Dudas, S. Menendez, I. Matushansky, J. Mills, N. D. Socci, N. Behrendt, L. Ma, R. G. Maki, P. P. Pandolfi, and C. Cordon-Cardo. The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nat. Med. 13 748-753 (2007). (Pubitemid 46889749)
34. J. Brognard, A. S. Clark, Y. Ni, and P. K. Dennis. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res. 61 3986-3997 (2001). (Pubitemid 32720961)
35. P. Ghosh, M. Garcia-Marcos, S. J. Bornheimer, and M. G. Farquhar. Activation of Gai3 triggers cell migration via regulation of GIV. J. Cell Biol. 182 381-393 (2008).
36. B. Zhang, F. Gu, C. She, H. Guo, W. Li, R. Niu, L. Fu, N. Zhang, and Y. Ma. Reduction of Akt2 inhibits migration and invasion of glioma cells. Int. J. Cancer 125 585-595 (2009).
37. T. B. Pollard, and G. G. Borisy. Cellular motility driven by assembly and disassembly of actin filaments. Cell 112 453-465 (2003). (Pubitemid 36263079)
38. A. J. Ridley, M. A. Schwartz, K. Burridge, R. A. Firtel, M. H. Ginsberg, G. Borisy, J. T. Parsons, and A. R. Horwitz. Cell migration: Integrating signals from front to back. Science 302 1704-1709 (2003). (Pubitemid 37505725)
39. S. Etienne-Manneville, and A. Hall. Rho GTPases in cell biology. Nature 420 629-635 (2002). (Pubitemid 36764489)
40. P. Carmeliet, and R. K. Jain. Angiogenesis in cancer and other diseases. Nature 407 249-257 (2000).
41. N. Ferrara, and R. S. Kerbel. Angiogenesis as a therapeutic target. Nature 438 967-974 (2005). (Pubitemid 43093963)
42. L. Coultas, K. Chawengsaksophak, and J. Rossant. Endothelial cells and VEGF in vascular development. Nature 438 937-945 (2005). (Pubitemid 43093959)
43. D. Bilder. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev. 28 1909-1925 (2004). (Pubitemid 39071572)
44. F. Froldi, M. Ziosi, G. Tomba, F. Parisi, F. Garoia, A. Pession, and D. Grifoni. Drosophila lethal giant larvae neoplastic mutant as a genetic tool for cancer modeling. Current Genomics 9 147-154 (2008). (Pubitemid 351895017)
45. P. O. Humbert, L. E. Dow, and S. M. Russell. The Scribble and Par complexes in polarity and migration: friends or foes? Trends Cell Biol. 16 622-630 (2006). (Pubitemid 44809887)
46. A. C.-C. Jang, M. Starz-Gaiano, and D. J. Montell. Modeling migration and metastasis in Drosophila. J. Mammary Gland Biol. Neoplasia 12 103-114 (2007). (Pubitemid 47215428)
47. E. C. Woodhouse, A. Fisher, R. W. Bandle, B. Bryant-Greenwood, L. Charboneau, E. F. Petricoin, and L. A. Liotta. Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype. Proc. Natl. Acad. Sci. USA 100 11463-11468 (2003). (Pubitemid 37205958)
48. A. M. Brumby, and H. E. Richardson. Using Drosophila melanogaster to map human cancer pathways. Nat. Rev. Cancer 5 626-639 (2005). (Pubitemid 41081388)
49. R. A. Pagliarini, and T. Xu. A genetic screen in Drosophila for metastasis behavior. Science 302 1227- 1231 (2003). (Pubitemid 37421030)
50. R. J. Metzger, and M. A. Krasnow. Genetic control of branching morphogenesis. Science 284 1635-1639 (1999). (Pubitemid 29291366)
51. B. E. Kerman, A. M. Cheshire, and D. J. Andrew. From fate to function: the Drosophila trachea and salivary gland as models for tubulogenesis. Differentiation 74 326-348 (2006). (Pubitemid 44215406)
52. M. Affolter, S. Bellusci, N. Itoh, B. Shilo, J. P. Thiery, and Z. Werb. Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev. Cell 4 11-18 (2003). (Pubitemid 36105331)
53. K. J. Venken, and H. J. Bellen. Emerging technologies for gene manipulation in Drosophila melanogaster. Nat. Rev. Genet. 6 167-178 (2005). (Pubitemid 40293029)
54. M. Leyssen, and B. Hassan. A fruitfly's guide to keeping the brain wired. EMBO reports 8 46-50 (2007). (Pubitemid 46043799)
55. E. Bier. Drosophila, the golden bug, emerges as a tool for human genetics. Nat. Rev. Genet. 6 9-23 (2005). (Pubitemid 39657894)