Discovery of an oral potent selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS)

ACS Medicinal Chemistry Letters

Volumn 1, Issue 2, 2010, Pages 59-63

  Carron, Chris P ^a   Trujillo, John I ^a   Olson, Kirk L ^a   Huang, Wei ^a   Hamper, Bruce C ^a   Dice, Tom ^a   Neal, Bradley E ^a   Pelc, Matthew J ^a   Day, Jacqueline E ^a   Rohrer, Douglas C ^a   Kiefer, James R ^a   Moon, Joseph B ^a   Schweitzer, Barbara A ^a   Blake, Tanisha D ^a   Turner, Steve R ^a   Woerndle, Rhonda ^a   Case, Brenda L ^a   Bono, Christine P ^a   Dilworth, Vickie M ^a   Funckes Shippy, Christie L ^a   Hood, Becky L ^a   Jerome, Gina M ^a   Kornmeier, Christine M ^a   Radabaugh, Melissa R ^a   Williams, Melanie L ^a   Davies, Michael S ^a   Wegner, Craig D ^a   Welsch, Dean J ^a   Abraham, William M ^b   Warren, Chad J ^a   Dowty, Martin E ^a   Hua, Fengmei ^a   Zutshi, Anup ^a   Yang, Jerry Z ^a   Thorarensen, Atli ^a   more..

^a PFIZER INC   (United States)

^b MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

airway allergy, inflammatory processes, cyclooxygenase (COX); Hematopoietic prostaglandin D synthase (HPGDS); PGH2, PGD 2

Indexed keywords

ANTIINFLAMMATORY AGENT; HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITOR; THIAZOLE; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; IC 50; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

OVIS ARIES;

EID: 77956640094     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml900025z     Document Type: Article

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