Delaying the expression of herpes simplex virus type 1 glycoprotein B (gB) to a true late gene alters neurovirulence and inhibits the gB-CD8+ T-cell response in the trigeminal ganglion

Journal of Virology

Volumn 84, Issue 17, 2010, Pages 8811-8820

  Ramachandran, Srividya ^a   Davoli, Katherine A ^a   Yee, Michael B ^a   Hendricks, Robert L ^a   Kinchington, Paul R ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; GLYCOPROTEIN B; VIRUS DNA; GLYCOPROTEIN B, SIMPLEXVIRUS; VIRUS ENVELOPE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELL SIZE; CELL STIMULATION; CONTROLLED STUDY; DNA SYNTHESIS; EX VIVO STUDY; FEMALE; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; KERATITIS; LATENT VIRUS INFECTION; LIFE CYCLE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; T LYMPHOCYTE ACTIVATION; TRIGEMINUS GANGLION; VIRUS GENE; VIRUS GENOME; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS VIRULENCE; ANIMAL; C57BL MOUSE; CERCOPITHECUS; GENE EXPRESSION REGULATION; GENETICS; HERPES SIMPLEX; HUMAN; IMMUNOLOGY; PATHOGENICITY; VERO CELL; VIROLOGY; VIRULENCE;

HUMAN HERPESVIRUS 1; MUS; SIMPLEXVIRUS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CERCOPITHECUS AETHIOPS; FEMALE; GENE EXPRESSION REGULATION, VIRAL; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; MICE; MICE, INBRED C57BL; TRIGEMINAL GANGLION; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRULENCE;

EID: 77956635572     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00496-10     Document Type: Article

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