Enhanced gene transfection with addition of a cell-penetrating peptide in substrate-mediated gene delivery

Journal of Gene Medicine

Volumn 12, Issue 8, 2010, Pages 705-713

  Chen, Si ^a   Zhuo, Ren Xi ^a   Cheng, Si Xue ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Calcium phosphate; Functional polymers; Gene delivery; Peptide; Substrate mediated delivery

Indexed keywords

CELL PENETRATING PEPTIDE; CHOLIC ACID; KALA PEPTIDE; PEPTIDE DERIVATIVE; POLYLACTIDE; POLYMER; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL STRAIN HEK293; CELL STRAIN HEPG2; ENCAPSULATION; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; IN VITRO STUDY; PRIORITY JOURNAL;

CELL LINE; CELLS, CULTURED; DNA; DNA-BINDING PROTEINS; GENE THERAPY; HEP G2 CELLS; HUMANS; PEPTIDES; POLYESTERS; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 77956626868     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1488     Document Type: Article

References (22)

1. Bonadio J. Tissue engineering via local gene delivery: update and future prospects for enhancing the technology. Adv Drug Deliv Rev 2000; 44: 185-194.
2. Putnam D. Polymers for gene delivery across length scales. Nat Mater 2006; 5: 439-451.
3. Pannier AK, Shea LD. Controlled release systems for DNA delivery. Mol Ther 2004; 10: 19-26.
4. Gupta B, Levchenko TS, Torchilin VP. Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides. Adv Drug Deliv Rev 2005; 57: 637-651.
5. Fonseca SB, Pereira MP, Kelley SO. Recent advances in the use of cell-penetrating peptides for medical and biological applications. Adv Drug Deliv Rev 2009; 61: 953-964.
6. Deshayes S, Morris MC, Divita G, Heitz F. Cell-penetrating peptides: tools for intracellular delivery of therapeutics. Cell Mol Life Sci 2005; 62: 1839-1849. (Pubitemid 41188523)
7. Li W, Nicol F, Szoka FC Jr. GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery. Adv Drug Deliv Rev 2004; 56: 967-985.
8. Wyman TB, Nicol F, Zelphati O, Scaria PV, Plank C, Szoka FC Jr. Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers. Biochemistry 1997; 36: 3008-3017.
9. Fominaya J, Gasset M, García R, Roncal F, Albar JP, Bernad A. An optimized amphiphilic cationic peptide as an efficient nonviral gene delivery vector. J Gene Med 2000; 2: 455-464.
10. Rittner K, Benavente A, Bompard-Sorlet A, et al. New basic membrane-destabilizing peptides for plasmid-based gene delivery in vitro and in vivo. Mol Ther 2002; 5: 104-114.
11. Kim J, Lee SH, Choe J. Park TG. Intracellular small interfering RNA delivery using genetically engineered double-stranded RNA binding protein domain. J Gene Med 2009; 11: 804-812.
12. Mok H, Park TG. Self-crosslinked and reducible fusogenic peptides for intracellular delivery of siRNA. Biopolymers 2008; 89: 881-888.
13. Min SH, Lee DC, Lim MJ, et al. A composite gene delivery system consisting of polyethylenimine and an amphipathic peptide KALA. J Gene Med 2006; 8: 1425-1434.
14. Lee H, Jeong JH, Park TG. A new gene delivery formulation of polyethylenimine/DNA complexes coated with PEG conjugated fusogenic peptide. J Control Release 2001; 76: 183-192.
15. Lee H, Jeong JH, Park TG. PEG grafted polylysine with fusogenic peptide for gene delivery: high transfection efficiency with low cytotoxicity. J Control Release 2002; 79: 283-291. (Pubitemid 34164180)
16. Lim DW, Yeom YI, Park TG. Poly(DMAEMA-NVP)-b-PEG-galactose as gene delivery vector for hepatocytes. Bioconjugate Chem 2000; 11: 688-695.
17. DL-lactide)s for biomedical applications. J Biomed Mater Res B Appl Biomater 2007l; 82B: 400-407.
18. Zhang Q, Zhao D, Zhang XZ, Cheng SX, Zhuo RX. Calcium phosphate/DNA co-precipitates encapsulated fast degrading polymer films for substrate-mediated gene delivery. J Biomed Mater Res B Appl Biomater 2009; 91B: 172-180.
19. Li YQ, Li F, Zhang XZ, Cheng SX, Zhuo RX. Three dimensional fast degrading polymer films for delivery of calcium phosphate/DNA co-precipitates in solid-phase transfection. J Mater Chem 2009; 19: 6733-6739.
20. DL-lactide) for localized gene delivery. J Control Release 2007; 124: 181-188.
21. Vivès E, Schmidt J, Pèlegrin A. Cell-penetrating and cell-targeting peptides in drug delivery. Biochim Biophys Acta 2008; 1786: 126-138.
22. Sokolova V, Kovtun A, Heumann R, Epple M. Tracking the pathway of calcium phosphate/DNA nanoparticles during cell transfection by incorporation of red-fluorescing tetramethylrhodamine isothiocyanate-bovine serum albumin into these nanoparticles. J Biol Inorg Chem 2007; 12: 174-179.