MDMA administration and heat shock proteins response: Foreseeing a molecular link

Current Pharmaceutical Biotechnology

Volumn 11, Issue 5, 2010, Pages 496-499

  Pomara, C ^a   D'Errico, S ^a   Zummo, L ^b   Cappello, F ^b   Li Volti, G ^c,d  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

^d IRCCS   (Italy)

Author keywords

3,4 Methylenedioxy N methylamphetamine; Brain toxicity; Hsp27; Hsp32; Hsp60; Hsp70

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; CHAPERONE; HEAT SHOCK PROTEIN;

ARTICLE; BRAIN TISSUE; CHRONIC TOXICITY; DRUG CYTOTOXICITY; HUMAN; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION;

ANIMALS; BRAIN; HALLUCINOGENS; HEAT-SHOCK PROTEINS; HEAT-SHOCK RESPONSE; HUMANS; MODELS, NEUROLOGICAL; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE;

EID: 77956599499     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920110791591445     Document Type: Article

References (62)

1. Campbell, G.A.; Rosner, M.H. The agony of ecstasy: MDMA (3,4-methylenedioxymethamphetamine) and the kidney. Clin. J. Am. Soc. Nephrol., 2008, 3(6), 1852-1860.
2. Skelton, M.R.; Williams, M.T.; Vorhees, C.V. Developmental effects of 3,4-methylenedioxymethamphetamine: a review. Behav. Pharmacol., 2008, 19(2), 91-111.
3. Yamamoto, B.K.; Raudensky, J. The role of oxidative stress, metabolic compromise, and inflammation in neuronal injury produced by amphetamine-related drugs of abuse. J. Neuroimmune. Pharmacol., 2008, 3(4), 203-217.
4. Capela, J.P.; Carmo, H.; Remião, F.; Bastos, M.L.; Meisel, A.; Carvalho, F. Molecular and cellular mechanisms of ecstasy-induced neurotoxicity: an overview. Mol. Neurobiol., 2009, 39(3), 210-271.
5. Gouzoulis-Mayfrank, E.; Daumann, J. Neurotoxicity of drugs of abuse--the case of methylenedioxyamphetamines (MDMA, ecstasy), and amphetamines. Dialogues Clin. Neurosci., 2009, 11(3), 305-317.
6. Peters, G.J.; Kok, G. A structured review of reasons for ecstasy use and related behaviours: pointers for future research. BMC Public Health, 2009, 13(9), 230.
7. Kültz, D. Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function. J. Exp. Biol., 2003, 206(pt. 18), 3119-3124.
8. Kampinga, H.H.; Hageman, J.; Vos, M.J.; Kubota, H.; Tanguay, R.M.; Bruford, E.A.; Cheetham, M.E.; Chen, B.; Hightower, L.E. Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones, 2009, 14(1), 105-111.
9. Li, Z.; Srivastava, P. Heat-shock proteins. Curr. Protoc. Immunol., 2004, Appendix 1:Appendix 1T.
10. Calderwood, S.K.; Mambula, S.S.; Gray, P.J. Jr; Theriault, J.R. Extracellular heat shock proteins in cell signaling. FEBS Lett., 2007, 581(19), 3689-3694.
11. Sutmuller, R.; Garritsen, A.; Adema, G.J. Regulatory T cells and toll-like receptors: regulating the regulators. Ann. Rheum. Dis., 2007, 66(suppl. 3), 91-95.
12. Li Volti, G.; Galvano, F.; Frigiola, A.; Guccione, S.; Di Giacomo, C.; Forte, S.; Tringali, G.; Caruso, M.; Adekoya, O.A.; Gazzolo, D. Potential immunoregulatory role of heme oxygenase-1 in human milk: a combined biochemical and molecular modeling approach. J. Nutr. Biochem., 2009, [Epub ahead of print].
13. Ellis, R.J. Chaperonins. Curr. Biol., 1999, 9(10), R352.
14. Macario, A.J.; Conway de Macario, E. Stress and molecular chaperones in disease. Int. J. Clin. Lab. Res., 2000, 30(2), 49-66.
15. Macario, A.J.; Conway de Macario, E. Molecular chaperones: multiple functions, pathologies, and potential applications. Front Biosci., 2007, 1(12), 2588-2600.
16. Macario, A.J.; Conway de Macario, E. Chaperones, cellular stress, and disease. N. Engl. J. Med., 2005, 353(14), 1489-1501.
17. Cappello, F.; Conway de Macario, E.; Di Felice, V.; Zummo, G.; Macario, AJ. Chlamydia trachomatis infection and anti-Hsp60 immunity: the two sides of the coin. PLoS Pathog., 2009, 5(8), e1000552.
18. Calderwood, S.K.; Ciocca, DR. Heat shock proteins: stress proteins with Janus-like properties in cancer. Int. J. Hyperthermia, 2008, 24(1), 31-39.
19. Cappello, F.; de Macario, E.C.; Marasà, L.; Zummo, G.; Macario, A.J. Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy. Cancer Biol. Ther., 2008, 7(6), 801-809.
20. Brocchieri, L.; Conway de Macario, E.; Macario, A.J. Chaperonomics, a new tool to study ageing and associated diseases. Mech. Ageing Dev., 2007, 128(1), 125-136.
21. Macario, A.J.; de Macario, E.C. The pathology of cellular antistress mechanisms: a new frontier. Stress, 2004, 7(4), 243-249.
22. Pubill, D.; Canudas, A.M.; Pallàs, M.; Camins, A.; Camarasa, J.; Escubedo, E. Different glial response to methamphetamine-and methylenedioxymethamphetamine-induced neurotoxicity. Naunyn Schmiedebergs Arch. Pharmacol., 2003, 367(5), 490-499.
23. Adori, C.; Andó, R.D.; Kovács, G.G.; Bagdy, G. Damage of serotonergic axons and immunolocalization of Hsp27, Hsp72, and Hsp90 molecular chaperones after a single dose of MDMA administration in Dark Agouti rat: temporal, spatial, and cellular patterns. J. Comp. Neurol., 2006, 497(2), 251-269.
24. Wang, X.; Baumann, M.H.; Xu, H.; Morales, M.; Rothman, R.B. (+/-)-3,4-Methylenedioxymethamphetamine administration to rats does not decrease levels of the serotonin transporter protein or alter its distribution between endosomes and the plasma membrane. J Pharmacol. Exp. Ther., 2005, 314(3), 1002-1012.
25. Ferrucci, M.; Gesi, M.; Lenzi, P.; Soldani, P.; Ruffoli, R.; Pellegrini, A.; Ruggieri, S.; Paparelli, A.; Fornai, F. Noradrenergic loss enhances MDMA toxicity and induces ubiquitin-positive striatal whorls. Neurol. Sci., 2002, 23(suppl. 2), 75-76.
26. Escobedo, I.; Peraile, I.; Orio, L.; Colado, M.I.; O'Shea, E. Evidence for a role of Hsp70 in the neuroprotection induced by heat shock pre-treatment against 3,4-methylenedioxymethamphetamine toxicity in rat brain. J. Neurochem., 2007, 101(5), 1272-1283.
27. Sharma, H.S.; Ali, S.F. Acute administration of 3,4-methylene-dioxymethamphetamine induces profound hyperthermia, bloodbrain barrier disruption, brain edema formation, and cell injury. Ann. N Y Acad. Sci., 2008, 1139, 242-258.
28. Riezzo, I.; Cerretani, D.; Fiore, C.; Bello, S.; Centini, F.; D'Errico, S.; Fiaschi, A.; Giorgi, G.; Neri, M.; Pomara, C.; Turillazzi, E.; Fineschi, V. Enzymatic-nonenzymatic cellular antioxidant defense systems response and immunohistochemical detection of MDMA, VMAT2, HSP70, and apoptosis as biomarkers for MDMA (Ecstasy) neurotoxicity. J. Neurosci. Res., 2010, 88(4), 905-916.
29. Fornai, F.; Lenzi, P.; Frenzilli, G.; Gesi, M.; Ferrucci, M.; Lazzeri, G.; Biagioni, F.; Nigro, M.; Falleni, A.; Giusiani, M.; Pellegrini, A.; Blandini, F.; Ruggieri, S.; Paparelli A. DNA damage and ubiquitinated neuronal inclusions in the substantia nigra and striatum of mice following MDMA (ecstasy). Psychopharmacology, (Berl), 2004, 173(3-4), 353-363.
30. Hartl, F.U. DNA damage and ubiquitinated neuronal inclusions in the substantia nigra and striatum of mice following MDMA (ecstasy). Nature, 1996, 381(6583), 571-579.
31. Hartl, F.U.; Hayer-Hartl, M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science, 2002, 295(5561), 1852-1858.
32. Lindquist, S.; Craig, E.A. The heat-shock proteins. Annu. Rev. Genet., 1988, 22, 631-677.
33. Wells, A.D.; Malkovsky, M. Heat shock proteins, tumor immunogenicity and antigen presentation: an integrated view. Immunol. Today, 2000, 21(3), 129-132.
34. Jaattela, M.; Wissing, D.; Kokholm, K.; Kallunki, T.; Egeblad, M. Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases. EMBO J., 1998, 17(21), 6124-6134.
35. Saleh, A.; Srinivasula, S.M.; Balkir, L.; Robbins, P.D.; Alnemri, E.S. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat. Cell Biol., 2000, 2(8), 476-483.
36. Beere, H.M.; Wolf, B.B.; Cain, K. Hsp 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat. Cell Biol., 2000, 2(8), 469-475.
37. Ehrhart, J.C.; Duthu, A.; Ullrich S.; Appella, E.; May, P. Specific interaction between a subset of the p53 protein family and heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line. Oncogene, 1998, 3(5), 595-603.
38. Nihei, T.; Sato, N.; Takahashi, S.; Ishikawa, M.; Sagae, S.; Kudo, R.; Kikuchi, K.; Inoue, A. Demonstration of selective protein complexes of p53 with 73 kDa heat shock cognate protein, but not with 72 kDa heat shock protein in human tumor cells. Cancer Lett., 1993, 73(2-3), 181-189.
39. Kaufmann, S.H. Heat shock proteins and the immune response. Immunol. Today, 1990, 11(4), 129-136.
40. Benjamin, I.J. Stress proteins: is their application in clinical medicine on the horizon? Hepatology, 1993, 18(6), 1532-1534.
41. Ciocca, D.R.; Oesterreich, S.; Chamness, G.C.; McGuire, W.L.; Fuqua, S.A. Biological and clinical implications of heat shock protein 27,000 (Hsp27). A review. J. Natl. Cancer Inst., 1993, 85(19), 1558-1570.
42. Bonkhoff, H.; Fixemer, T.; Hunsicker, I.; Remberger, K. Estrogen receptor gene expression and its relation to the estrogen-inducible HSP27 heat shock protein in hormone-refractory prostate cancer. Prostate, 2000, 45(1), 36-41.
43. Oesterreich, S.; Weng, C.N.; Qiu, M.; Hilsenbeck, S.G.; Osborne, C.K.; Fuqua, S.A. The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res., 1993, 53(19), 4443-4448.
44. Hansen, R.K.; Parra, I.; Lemieux, P.; Oesterreich, S.; Hilsenbeck, S.G.; Fuqua, S.A. Hsp27 overexpression inhibits doxorubicin-induced apoptosis in human breast cancer cells. Breast Cancer Res. Treat., 1999, 56(2), 187-196.
45. Lemieux, P.; Oesterreich, S.; Lawrence, J.A. The small heat shock protein hsp27 increases invasiveness but decreases motility of breast cancer cells. Invasion Metastasis, 1997, 17(3), 113-123.
46. Garrido, C.; Fromentin, A.; Bonnotte, B. Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones. Cancer Res., 1998, 58(23), 5495-5499.
47. Bruey, J.M.; Paul, C.; Fromentin, A. Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo. Oncogene, 2000, 19(42), 4855-4863.
48. Arrigo, A.P. Hsp27: A novel regulator of intracellular redox state. IUBMB Life, 2001, 52(6), 303-307.
49. Morse, D.; Choi, A.M. Heme oxygenase-1: the emerging molecule has arrived. Am. J. Respir. Cell Mol. Biol., 2002, 27(1), 8-16.
50. Morse, D.; Choi, A.M.K. Heme oxygenase-1: from bench to bedside. Am. J. Respir Crit. Care Med., 2005, 172(6), 660-670.
51. Dennery, P.A.; Sridhar, K.J.; Lee, C.S.; Wong, H.E.; Shokoohi, V.; Rodgers, P.A.; Spitz, D.R. Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts. J. Biol. Chem., 1997, 272(23), 14937-14942.
52. Suttner, D.M.; Sridhar, K.; Lee, C.S.; Tomura, T.; Hansen, T.N.; Dennery, P.A. Protective effects of transient HO-1 overexpression on susceptibility to oxygen toxicity in lung cells. Am. J. Physiol., 1999, 276(3), 443-451.
53. Acquaviva, R.; Campisi, A.; Murabito, P.; Raciti, G.; Avola, R.; Mangiameli, S.; Musumeci, I.; Barcellona, M.L.; Vanella, A.; Li Volti, G. Propofol attenuates peroxynitrite-mediated DNA damage and apoptosis in cultured astrocytes: an alternative protective mechanism. Anesthesiology, 2004, 101(6), 1363-1371.
54. Lee, P.J.; Alam, J.; Wiegand, G.W.; Choi, A.M. Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc. Natl. Acad. Sci. USA, 1996, 93(19), 10393-10398.
55. Otterbein, L.; Sylvester, S.L.; Choi, A.M. Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1. Am. J. Respir Cell Mol. Biol., 1995, 13(5), 595-601.
56. Otterbein, L.; Chin, B.Y.; Otterbein, S.L.; Lowe, V.C.; Fessler, H.E.; Choi, A.M. Mechanism of hemoglobin-induced protection against endotoxemia in rats: a ferritin-independent pathway. Am. J. Physiol., 1997, 272(2), 268-275.
57. Pontes, H.; Duarte, J.H.; de Pinho, P.G.; Soares, M.E.; Fernandes, E.; Dinis-Oliveira, R.J.; Sousa, C.; Silva, R.; Carmo, H.; Casal, S.; Remião, F.; Carvalho, F.; Bastos, M.L. Chronic exposure to ethanol exacerbates MDMA-induced hyperthermia and exposes liver to severe MDMA-induced toxicity in CD1 mice. Toxicology, 2008, 252(1-3), 64-71.
58. Voellmy, R. Feedback regulation of the heat shock response. Handb Exp. Pharmacol., 2006, 172, 43-68.
59. Itoh, H.; Tashima, Y. The stress (heat shock) proteins. Int. J. Biochem., 1991, 23(11), 1185-1191.
60. Moon, K.H.; Upreti, V.V.; Yu, L.R.; Lee, I.J.; Ye, X.; Eddington, N.D.; Veenstra, T.D.; Song, B.J. Mechanism of 3,4-methylene-dioxymethamphetamine (MDMA, ecstasy)-mediated mitochondrial dysfunction in rat liver. Proteomics, 2008, 8(18), 3906-3918.
61. Czarnecka, A.M.; Campanella, C.; Zummo, G.; Cappello, F. Mitochondrial chaperones in cancer from molecular biology to clinical diagnostics. Cancer Biol. Ther., 2006, 5(7), 714-720.
62. Ghosh, J.C.; Doshi, T.; Kang, B.H.; Altieri, D.C. Hsp60 regulation of tumor cell apoptosis. J. Biol. Chem., 2008, 283(8), 5188-5194.