DNA damage and ubiquitinated neuronal inclusions in the substantia nigra and striatum of mice following MDMA (ecstasy)

Psychopharmacology

Volumn 173, Issue 3-4, 2004, Pages 353-363

  Fornai, F ^a,b   Lenzi, P ^a   Frenzilli, G ^a   Gesi, M ^a   Ferrucci, M ^a   Lazzeri, G ^a   Biagioni, F ^b   Nigro, M ^a   Falleni, A ^a   Giusiani, M ^a   Pellegrini, A ^a   Blandini, F ^c   Ruggieri, S ^b   Paparelli, A ^a  

^a UNIVERSITY OF PISA   (Italy)

^b IRCCS NEUROMED   (Italy)

^c C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

Author keywords

3,4 Methylenedioxymethamphetamine; Basal ganglia; Comet assay; Heat shock protein (HSP) 70; Immuno electron microscopy; Neuronal inclusions; Neurotoxicity; Ubiquitin proteasome system; Whorls

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; DNA BASE; DOPAMINE; HEAT SHOCK PROTEIN 70; PROTEASOME; SEROTONIN; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INCLUSION; CELL NUCLEUS; CELL STRAIN; CELL STRUCTURE; CELLULAR DISTRIBUTION; CHROMATIN; COMET ASSAY; CONTROLLED STUDY; CORPUS STRIATUM; CYTOPLASM; DNA DAMAGE; DNA DETERMINATION; DOPAMINERGIC NERVE CELL; ELECTRON MICROSCOPY; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INNERVATION; MALE; MICROSCOPY; MOUSE; NERVE CELL; NERVE CELL CULTURE; NEUROTOXICITY; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OXIDATION; PERIKARYON; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SEROTONIN RELEASE; SUBSTANTIA NIGRA;

ANIMALS; CORPUS STRIATUM; DNA DAMAGE; DOPAMINE; MALE; MICE; MICE, INBRED C57BL; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEURONS; PC12 CELLS; RATS; SEROTONIN AGENTS; SUBSTANTIA NIGRA; UBIQUITIN;

EID: 2542638534     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1708-3     Document Type: Article

References (34)

1. Abe T, Konishi T, Hirano T, Kasai H, Shimizu K, Kashimura M, Higashi K (1995) Possible correlation between DNA damage induced by hydrogen peroxide and translocation of heat shock 70 protein into the nucleus. Biochem Biophys Res Commun 206:548-555
2. Battaglia G, Yeh SY, De Souza EB (1988) MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons. Pharmacol Biochem Behav 29:269-274
3. Cadet JL, Ladenheim B, Hirata H, Rothman RB, Ali S, Carlson E, Epstein C, Moran TH (1995) Superoxide radicals mediate the biochemical effects of methylenedioxymethamphetamine (MDMA): evidence from using CuZn-superoxide dismutase transgenic mice. Synapse 21:169-176
4. Colado MI, Camarero J, Mechan AO, Sanchez V, Esteban B, Elliott JM, Green AR (2001) A study of the mechanisms involved in the neurotoxic effects of 3,4 methylenedioxymethamphetamine (MDMA, ecstasy) on dopamine neurones in mouse brain. Br J Pharmacol 134:1711-1723
5. Collins AR, Ma AG, Duthie SJ (1995) The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells. Mutat Res 336:69-77
6. Finnegan KT, Ricaurte GA, Ritchie LD, Irwin I, Peroutka SJ, Langston JW (1988) Orally administered MDMA causes a long-term depletion of serotonin in rat brain. Brain Res 447:141-144
7. Fornai F, Chen K, Giorgi FS, Gesi M, Alessandri MG, Shih JC (1999) Striatal dopamine metabolism in monoamine oxidase B-deficient mice: a brain dialysis study. J Neurochem 73:2434-2440
8. Fornai F, Giorgi FS, Gesi M, Chen K, Alessandrì MG, Shih JC (2001) Biochemical effects of monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B-deficient mice. Synapse 39:213-221
9. Fornai F, Lenzi P, Gesi M, Ferrucci M, Lazzeri G, Busceti CL, Ruffoli R, Soldani P, Ruggieri S, Alessandrì MG, Paparelli A (2003) Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death following proteasome inhibitors. J Neurosci 23:8955-8966
10. Gibb JW, Johnson M, Hanson GR (1990) Neurochemical basis of toxicity. Neurotoxicology 11:317-321
11. Green AR, Mechan AO, Elliot JM, O'Shea E, Colado MI (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Pharmacol Rev 55:463-508
12. Gudelsky GA, Yamamoto BK (2003) Neuropharmacology and neurotoxicity of 3,4-methylenedioxymethamphetamine. Methods Mol Med 79:55-73
13. Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67:425-479
14. Itzhak Y, Ali SF, Achat CN, Anderson KL (2003) Relevance of MDMA ("ecstasy")-induced neurotoxicity to long-lasting psychomotor stimulation in mice. Psychopharmacology 166:241-248
15. Jayanthi S, Ladenheim B, Andrews AM, Cadet JL (1999) Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (ecstasy). Neuroscience 91:1379-1387
16. Klaude M, Eriksson S, Nygren J, Ahnstrom G (1996) The comet assay: mechanisms and technical considerations. Mutat Res 363:89-96
17. Larsen KE, Fon EA, Hastings TG, Edwards RH, Sulzer D (2002) Methamphetamine-induced degeneration of dopaminergic neurons involves autophagy and upregulation of dopamine synthesis. J Neurosci 22:8951-8960
18. Logan BJ, Laverty R, Sanderson WD, Yee YB (1988) Differences between rats and mice in MDMA (methylenedioxymethamphetamine) neurotoxicity. Eur J Pharmacol 152:227-234
19. Lyles J, Cadet JL (2003) Methylenedioxymethamphetamine (MDMA, ecstasy) neurotoxicity: cellular and molecular mechanisms. Brain Res Rev 42:155-168
20. Miyamae Y, Iwasaki K, Kinae N, Tsuda S, Murakami M, Tanaka M, Sasaki YF (1997) Detection of DNA lesions induced by chemical mutagens by the single-cell gel electrophoresis (Comet) assay. 2. Relationship between DNA migration and alkaline conditions. Mutat Res 393:107-113
21. O'Hearn E, Battaglia G, De Souza EB, Kuhar MJ, Molliver ME (1988) Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity. J Neurosci 8:2788-2803
22. O'Shea E, Esteban B, Camarero J, Green AR, Colado MI (2000) Effect of GBR 12909 and fluoxetine on the acute and long-term changes induced by MDMA ("ecstasy") on the 5HT and dopamine concentrations in mouse brain. Neuropharmacology 40:65-74
23. Parrott AC, Milani RM, Parmar R, Turner JD (2001) Recreational ecstasy/MDMA and other drug users from U.K. and Italy: psychiatric symptoms and psychobiological problems. Psychopharmacology 159:77-82
24. Pope HG Jr, Ionescu-Pioggia M, Pope KW (2001) Drug use and life style among college undergraduates: a 30-year longitudinal study. Am J Psychiatry 158:1519-1521
25. Ricaurte GA, DeLanney LE, Iewin I, Langston JW (1988) Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration. Brain Res 446:165-168
26. Schmidt CJ (1987) Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. J Pharmacol Exp Ther 240:1-7
27. Sherman MY, Goldberg AL (1996) Involvement of molecular chaperones in intracellular protein breakdown. In: Feige U, Morimoto RI, Yahara I, Polla BS (eds) Stress-inducible cellular response. Birkhauser Verlag, Basel, pp 57-78
28. Sherman MY, Goldberg AL (2001) Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron 29:15-32
29. Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191
30. Singh NP, Lai H, Khan A (1995) Ethanol-induced single-strand DNA breaks in rat brain cells. Mutat Res 345:191-196
31. States BA, Honkaniemi J, Weinstein PR, Sharp FR (1996) DNA fragmentation and HSP70 protein induction in hippocampus and cortex occurs in separate neurons following permanent middle cerebral artery occlusions. J Cereb Blood Flow Metab 16:1165-1175
32. Strot J, Lee JE, Wechsler H (2002) Increasing MDMA use among college students: results of a national survey. J Adolesc Health 30:64-72
33. Zheng YW, Laverty R (1993) Neurotoxic effects of MDMA in different strains of mice. Proc Univ Otago Med Sch 71:5-6
34. Zhou JF, Chen P, Zhou YH, Chen HH (2003) 3,4- Methylenedioxymethamphetamine (MDMA) abuse may cause oxidative stress and potential radical damage. Free Radic Res 37:491-497