Cytotoxicity of β-carotene cleavage products and its prevention by antioxidants

Acta Biochimica Polonica

Volumn 57, Issue 2, 2010, Pages 217-221

  Alija, Avdulla J ^a   Bresgen, Nikolaus ^b   Bojaxhi, Ekramije ^b   Vogl, Cornelia ^b   Siems, Werner ^c   Eckl, Peter M ^b  

^a UNIVERSITY OF PRISHTINA   (Serbia)

^b UNIVERSITY OF SALZBURG   (Austria)

^c Institute of Physiotherapy and Gerontology   (Germany)

Author keywords

Antioxidants; Apoptosis; Hepatocytes; Necrosis; carotene cleavage products

Indexed keywords

RATTUS;

EID: 77956546775     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: 10.18388/abp.2010_2397     Document Type: Article

References (47)

1. Agarwal S, Rao AV (2000) Carotenoids and chronic diseases. Drug Metabol Drug Interac 17: 189-210.
2. Aidoo A, Lyn-Cook LE, Lensing S, Bishop ME, Wamer W (1995) In vivo antimutagenic activity of beta-carotene in rat spleen lymphocytes. Carcinogenesis 16: 2237-2241.
3. Alija AJ, Bresgen N, Sommerburg O, Siems W, Eckl PM (2004) Cytotoxic and genotoxic effects of beta-carotene breakdown products on primary rat hepatocytes. Carcinogenesis 25: 827-831.
4. Alija AJ, Bresgen N, Sommerburg O, Langhans CD, Siems W, Eckl PM (2006) Beta-carotene breakdown products enhance genotoxic effects of oxidative stress in primary rat hepatocytes. Carcinogenesis 27: 1128-1133.
5. Arriaga-Alba M, Rivera-Sanchez R, Parra-Cervantes G, Barro-Moreno F, Flores-Paz R, Garcia-Jimenez E (2000) Antimutagenesis of betacarotene to mutations induced by quinolone on Salmonella typhimurium. Arch Med Res 31: 156-161.
6. Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA (2007) NAcetylcysteine - a safe antidote for cysteine/glutathione deficiency. Curr Opin Pharmacol 7: 355-359.
7. Blumberg J, Block G (1994) The alpha-tocopherol, beta-carotene cancer prevention study in finland. Nutr Rev 52: 242-245.
8. Bresgen N, Ohlenschläger I, Wacht N, Afazel S, Ladurner G, Eckl PM (2008) Ferritin and FasL (CD95L) mediate density dependent apoptosis in primary rat hepatocytes. J Cell Physiol 217: 800-808.
9. Dekhuijzen PN, van Beurden WJ (2006) The role for N-acetylcysteine in the management of COPD. Int J Chron Obstruct Pulmon Dis 1: 99-106.
10. Edinger AL, Thompson CB (2004) Death by design: Apoptosis, necrosis and autophagy. Curr Opin Cell Biol 16: 663-669.
11. Ethier C, Raymond V-A, Musallam L, Houle R, Bilodeau M (2003) Antiapoptotic effect of EGF on mouse hepatocytes associated with downregulation of proapoptotic Bid protein. Am J Physiol Gastrointes Liver Physiol 285: G298-G308.
12. Fishbane S (2008) N-Acetylcysteine in the prevention of contrast-induced nephropathy. Clin J Am Soc Nephrol 3: 281-287.
13. Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann R (1995) In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology 21: 1465- 1468.
14. Hallfrisch J, Muller DC, Singh VN (1994) Vitamin A and E intakes and plasma concentrations of retinol, β-carotene and α-tocopherol in men and women of the Baltimore Longitudinal Study of Aging. Am J Clin Nutr 60: 176-182.
15. Halliwell B (2000) The antioxidant paradox. Lancet 355: 1179-1180.
16. Huerta S, Goulet EJ, Huerta-Ypez S, Livingston EH (2007) Screening and detection of apoptosis. J Surg Res 139: 143-156.
17. Jaeschke H, Bajt ML (2006) Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 89: 31-41.
18. Laurora S, Tamagno E, Briatore F, Bardini P, Pizzimenti S, Toaldo C, Reffo P, Costelli P, Dianzani MU, Danni O, Barrera G (2005) 4-Hydroxynonenal modulation of p53 family gene expression in the SK-N-BE neuroblastoma cell line. Free Radic Biol Med 38: 215-225.
19. Li S, Chien S, Brånemark P-I (2005) Heat shock-induced necrosis and apoptosis in osteoblasts. J Orthopaed Res 6: 891-899.
20. Liu C, Russell RM, Wang X-D (2004) (-Tocopherol and ascorbic acid decrease the production of β-apo-carotenals and increase the formation of retinoids from β-carotene in the lung tissues of cigarette smoke-exposed ferrets in vitro. J Nutr 134: 426-430.
21. Lu QY, Hung JC, Heber D, Go VL, Reuter VE, Cordon-Cardo C, Scher HI, Marshall JR, Zhang ZF (2001) Inverse associations between plasma lycopene and other carotenoids and prostate cancer. Cancer Epidemiol Biomarkers Prev 10: 749-756.
22. Marques SA, Loureiro AP, Gomes OF, Garcia CC, DiMascio P, Medeiros MH (2004) Induction of 1,N(2)-etheno-2'-deoxyguanosine in DNA exposed to beta-carotene oxidation products. FEBS Lett 560: 125-130.
23. McClain DE, Kalinich JF, Ramakrishnan N (1995) Trolox inhibits apoptosis in irradiated MOLT-4 lymphocytes. FASEB J 9: 1345-1354.
24. Miranda CL, Reed RL, Kuiper HC, Alber S, Stevens JF (2009) Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells. Chem Res Toxicol 22: 863-874.
25. Michalopoulos G, Cianciulli HD, Novotny AR, Kligerman AD, Strom SC, Jirtle RL (1982) Liver regeneration studies with rat hepatocytes in primary culture. Cancer Res 42: 4673-4682.
26. Müller M, Wilder S, Bannasch D, Israeli D, Lehlbach K, Li-Weber M, Friedman SL, Galle PR, Stremmel W, Oren M, Krammer PH (1998) p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med 188: 2033-2045.
27. Murata M, Kawanishi S (2000) Oxidative DNA damage by vitamin A and its derivative via superoxide generation. J Biol Chem 275: 2003- 2008.
28. Musallam L, Ethier C, Haddad PS, Bilodeau M (2001) Role of EGF receptor tyrosine kinase activity in antiapoptotic effect of EGF on mouse hepatocytes. Am J Physiol Gastrointest Liver Physiol 280: G1360-G1369.
29. Oberhammer FA, Pavelka M, Sharma S, Tiefenbacher R, Purchio AF, Bursch W, Schulte-Hermann R (1992) Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor beta 1. Proc Natl Acad Sci 89: 5408-5412.
30. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr., Valanis B, Williams JH Jr., Barnhart S, Cherniack MG, Brodkin CA, Hammar S (1996) Risk factors for lung cancer and for intervention effects in CARET, the beta-carotene and retinol efficacy trial. J Natl Cancer Inst 88: 1550- 1559.
31. Olson JA, Krinsky NI (1995) Introduction: The colourful, fascinating world of the carotenoids: important physiologic modulators. FASEB J 9: 1547-1550.
32. Rauscher R, Edenharder R, Platt KL (1998) In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids. Mutat Res 413: 129- 142.
33. Salgo MG, Pryor WA (1996) Trolox inhibits peroxinitrite-mediated oxidative stress and apoptosis in rat thymocytes. Arch Biochem Biophys 333: 482-488.
34. Sandoval M, Zhang X-J, Liu X, Mannick EE, Clark DA, Miller MJS (1997) Peroxynitrite-induced apoptosis in T84 and RAW 264.7 cells: attenuation by L-ascorbic acid. Free Radic Biol Med 22: 489-495.
35. Sharma R, Sharma A, Dwivedi S, Zimniak P, Awasthi S, Awasthi YC (2008) 4-Hydroxynonenal self-limits Fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas. Biochemistry 47: 143-156.
36. Siems WG, Sommerburg O, Hurst JS, van Kuijk FJ (2000) Carotenoid oxidative degradation products inhibit Na+-K+-ATPase. Free Radic Res 33: 427-435.
37. Siems W, Sommerburg O, Schild L, Augustin W, Langhans CD, Wiswedel I (2002) Beta-carotene cleavage products induce oxidative stress in vitro by impairing mitochondrial respiration. FASEB J 16: 1289-1291.
38. Sies H, Stahl W, Sundquist AR (1992) Antioxidant functions of vitamins. Vitamins E and C, beta- and other carotenoids. Ann N Y Acad Sci USA 669: 7-20.
39. Sommerburg O, Langhans C-D, Arnhold J, Leichsenring M, Salerno C, Crifo C, Hoffmann GF, Debatin K-M, Siems WG (2003) β-Carotene cleavage products after oxidation mediated via hypochlorous acid - a model for neutrophil-derived degradation. Free Radic Biol Med 35: 1480-1490.
40. Sprince H, Parker CM, Smith GG, Gonzales LJ (1975) Protective action of ascorbic acid and sulphur compounds against acetaldehyde toxicity: implication in alcoholism and smoking. Inflamm Res 5: 164-173.
41. Traber MG (2004) Vitamin E, nuclear receptors and xenobiotic metabolism. Arch Biochem Biophys 423: 6-11.
42. Vakkila J, Lotze MT (2004) Inflammation and necrosis promote tumour growth. Nat Rev Immunol 4: 641-648.
43. Wang XD, Russell RM (1999) Procarcinogenic and anticarcinogenic effects of b-carotene. Nutr Rev 57: 263-272.
44. Watanabe M, Sugimoto M, Ito K (1992) The acrolein cytotoxicity and cytoprotective action of α-tocopherol. J Gastroenterol 27: 199-205.
45. Wu TW, Hashimoto N, Wu J, Carey D, Li RK, Mickle DA, Weisel RD (1990) The cytoprotective effect of Trolox demonstrated with three types of human cells. Biochem Cell Biol 68: 1189-1194.
46. Zafarullah M, Li WQ, Sylvester J, Ahmad M (2003) Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 60: 6-20.
47. Zong W-X, Ditsworth D, Bauer DE, Wang Z-Q, Thompson CB (2004) Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18: 1272-1282.