The therapeutically anti-prion active antibody-fragment scfv-W226: Paramagnetic Relaxation-Enhanced NMR Spectroscopy aided Structure Elucidation of the Paratope-epitope Interface

Journal of Biomolecular Structure and Dynamics

Volumn 28, Issue 1, 2010, Pages 13-22

  Mangels, Christian ^a   Kellner, Ruth ^a   Einsiedel, Jürgen ^a   Weiglmeier, Philipp R ^a   Rösch, Paul ^a   Gmeiner, Peter ^b   Schwarzinger, Stephan ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Antibody; Drug design; Ligand binding; NMR spectroscopy; PRE; Prion protein

Indexed keywords

CYSTEINE; EPITOPE; LYSINE; PRION PROTEIN; PRION PROTEIN ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE W226 ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; INTROSPECTION; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARAMAGNETIC RELAXATION ENHANCED NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

EID: 77956523964     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2010.10507340     Document Type: Article

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