Solid-phase synthesis of peptides containing the spin-labeled 2,2,6,6-tetramethylpiperidine-1-oxyl-4-amino-4-carboxylic acid (TOAC)

Journal of Peptide Research

Volumn 58, Issue 5, 2001, Pages 424-432

  Martin, L ^a   Vita, C ^a   Ivancich, A ^a   Formaggio, F ^a   Toniolo, C ^a  

^a DIF   (France)

Author keywords

CD; EPR; HPLC; Nitroxide amino acid; Peptide synthesis; Solid phase synthesis; Spin labeled amino acid; Sterically hindered amino acid

Indexed keywords

2,2,6,6 TETRAMETHYLPIPERIDINE 1 OXYL 4 AMINO 4 CARBOXYLIC ACID; AMINO ACID; TEMPONE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BETA SHEET; ELECTRON SPIN RESONANCE; FLUORESCENCE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SOLID; STEREOSPECIFICITY;

EID: 0035189225     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2001.00940.x     Document Type: Article

References (28)

1. α-tetrasubstituted α-amino acid, is an excellent tool in materials science and biochemistry
2. Structural characteristics of α-helical peptide molecules containing Aib residues
3. Structures of polypeptides from amino acids disubstituted at the α-carbon
4. α,α-disubstituted glycine
5. N-Carboxyanhydride of 4-amino-4-carboxy-2,2,6,6-tetramethylpiperidine-1-oxyl, a new paramagnetic monomer
6. Nitroxides. 23. Preparation of amino acid free radicals and their complex salts
7. Studies of free radicals. I. α-Nitronyl nitroxides, a new class of stable radicals
8. Free radical analogs of histidine
9. Distinguishing helix conformation in alanine-rich peptides using the unnatural amino acid TOAC and electron spin resonance
10. Electron spin resonance and structural analysis of water soluble, alanine-rich peptides incorporating TOAC
11. A novel spin-labeled amino acid derivative for use in peptide chemistry: (9-fluorenylmethyloxycarbonyl) 2,2,6,6-Tetramethylpiperidine-N-oxyl-4-amino-4-carboxylic acid
12. Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methyl ester resin
13. New coupling reagents in peptide chemistry
14. HBTU activation for automated Fmoc solid-phase peptide synthesis
15. Synthesis and properties of spin-labeled angiotensin derivatives
16. 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive
17. Tetramethylfluoroformamidinium hexafluorophosphate: A rapid acting peptide coupling reagent for solution and solid phase peptide synthesis
18. Peptide synthesis via amino acids halides
19. A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis
20. Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking of protecting groups in peptide synthesis
21. 8]-dynorphin A
22. Large difference in the helix properties of alanine and glycine
23. α-tetrasubstituted α-amino acid for peptide conformational analysis by CD spectroscopy in the visible region
24. First synthesis of a fully spin-labeled peptide hormone
25. ESR spectra reflect local and global mobility in a short spin-labeled peptide throughout the α-helix-coil transition
26. A new spin: Peptide probes
27. First interchain peptide interaction detected by ESR in fully synthetic, template assisted, two-helix bundles
28. Neuropeptide Y analogues that contain spin- and fluorescence-labeled amino acids selectively bound to Y-receptors