Binding of tca to the prion protein: Mechanism, implication for therapy, and application as probe for complex formation of bio-macromolecules

Journal of Biomolecular Structure and Dynamics

Volumn 27, Issue 2, 2009, Pages 163-170

  Mangels, Christian ^a   Frank, Andreas O ^a   Ziegler, Jan ^a   Klingenstein, Ralph ^b   Schweimer, Kristian ^a   Willbold, Dieter ^b   Korth, Carsten ^b   Rösch, Paul ^a   Schwarzinger, Stephan ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

9 aminoacridine; Conformational disease; Drug design; In vitro binding assay; Ligand binding; NMR spectroscopy; Prion protein; Quinacrine; Relaxation

Indexed keywords

AMINACRINE; ANIMALS; HUMANS; MODELS, MOLECULAR; MOLECULAR PROBES; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PRION DISEASES; PRIONS; PROTEIN CONFORMATION; QUINACRINE;

AMINOACRIDINE; MEPACRINE; PRION PROTEIN; TRICYCLIC AROMATIC COMPOUND;

ARTICLE; BINDING KINETICS; DIMERIZATION; DRUG DESIGN; DRUG PROTEIN BINDING; IN VITRO SELECTION; LIGAND BINDING; MOLECULAR INTERACTION; PRION DISEASE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 67650439253     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2009.10507306     Document Type: Article

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