Heterophile antibodies rarely influence the measurement of thyroglobulin and thyroglobulin antibodies in differentiated thyroid cancer patients

Hormone and Metabolic Research

Volumn 42, Issue 10, 2010, Pages 736-739

  Verburg, F A ^a   Waschle K ^a   Reiners, C ^a   Giovanella, L ^b   Lentjes, E G W M ^c  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

follow up; heterophile antibody blocking; thyroid cancer

Indexed keywords

HETEROPHILE ANTIBODY; THYROGLOBULIN; THYROGLOBULIN ANTIBODY;

ADULT; ARTICLE; BLOOD SAMPLING; CANCER PATIENT; CONTROLLED STUDY; DIAGNOSTIC TEST; FEMALE; HASHIMOTO DISEASE; HISTOPATHOLOGY; HOSPITAL; HUMAN; INCUBATION TIME; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THYROGLOBULIN BLOOD LEVEL; THYROID CANCER; THYROID CARCINOMA; THYROID FUNCTION TEST;

ANTIBODIES, HETEROPHILE; AUTOANTIBODIES; CASE-CONTROL STUDIES; CELL DIFFERENTIATION; FEMALE; HUMANS; MALE; MIDDLE AGED; THYROGLOBULIN; THYROID FUNCTION TESTS; THYROID NEOPLASMS;

EID: 77956436120     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0030-1254132     Document Type: Article

References (15)

1. Schlumberger MJ. Papillary and follicular thyroid carcinoma. N Engl J Med 1998 338 297-306
2. Schlumberger M, Berg G, Cohen O, Duntas L, Jamar F, Jarzab B, Limbert E, Lind P, Pacini F, Reiners C, Franco FS, Toft A, Wiersinga WM. Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective. Eur J Endocrinol 2004 150 105-112 (Pubitemid 38312801)
3. Mazzaferri EL, Robbins RJ, Spencer CA, Braverman LE, Pacini F, Wartofsky L, Haugen BR, Sherman SI, Cooper DS, Braunstein GD, Lee S, Davies TF, Arafah BM, Ladenson PW, Pinchera A. A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 2003 88 1433-1441 (Pubitemid 36623351)
4. Pacini F, Schlumberger M, Dralle H, Elisei R, Smit JW, Wiersinga W. European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur J Endocrinol 2006 154 787-803
5. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Sherman SI, Tuttle RM. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2006 16 109-142
6. Benvenga S. Update on thyroid cancer. Horm Metab Res 2008 40 323-328
7. Spencer CA, Takeuchi M, Kazarosyan M, Wang CC, Guttler RB, Singer PA, Fatemi S, LoPresti JS, Nicoloff JT. Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab 1998 83 1121-1127
8. Spencer CA. Challenges of serum thyroglobulin (Tg) measurement in the presence of Tg autoantibodies. J Clin Endocrinol Metab 2004 89 3702-3704
9. Kricka LJ. Human anti-animal antibody interferences in immunological assays. Clin Chem 1999 45 942-956
10. Giovanella L, Ghelfo A. Undetectable serum thyroglobulin due to negative interference of heterophile antibodies in relapsing thyroid carcinoma. Clin Chem 2007 53 1871-1872
11. Giovanella L, Keller F, Ceriani L, Tozzoli R. Heterophile antibodies may falsely increase or decrease thyroglobulin measurement in patients with differentiated thyroid carcinoma. Clin Chem Lab Med 2009 47 952-954
12. Morgenthaler NG, Froehlich J, Rendl J, Willnich M, Alonso C, Bergmann A, Reiners C. Technical evaluation of a new immunoradiometric and a new immunoluminometric assay for thyroglobulin. Clin Chem 2002 48 1077-1083
13. Preissner CM, OKane DJ, Singh RJ, Morris JC, Grebe SK. Phantoms in the assay tube: heterophile antibody interferences in serum thyroglobulin assays. J Clin Endocrinol Metab 2003 88 3069-3074
14. Persoon AC, Links TP, Wilde J, Sluiter WJ, Wolffenbuttel BH, Van Den Ouweland JM. Thyroglobulin (Tg) recovery testing with quantitative Tg antibody measurement for determining interference in serum Tg assays in differentiated thyroid carcinoma. Clin Chem 2006 52 1196-1199
15. Massart C, Corcuff JB, Bordenave L. False-positive results corrected by the use of heterophilic antibody-blocking reagent in thyroglobulin immunoassays. Clin Chim Acta 2008 388 211-213