Depression, heart rate related variables and cardiovascular disease

International Journal of Psychophysiology

Volumn 78, Issue 1, 2010, Pages 80-88

  Taylor, C Barr ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Cardiovascular risk; Depression; Heart rate; Heart rate variability; Respiratory sinus arrhythmia

Indexed keywords

ARTICLE; AUTONOMIC DYSFUNCTION; BREATHING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL ASSESSMENT; DEPRESSION; HEART RATE; HEART RATE VARIABILITY; HUMAN; PSYCHOTHERAPY;

ANIMALS; CARDIOVASCULAR DISEASES; DEPRESSIVE DISORDER; HEART RATE; HUMANS; RISK FACTORS;

EID: 77956415576     PISSN: 01678760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpsycho.2010.04.006     Document Type: Article

References (104)

1. Balogh S., Fitzpatrick D.F., Hendricks S.E., Paige S.R. Increases in heart rate variability with successful treatment in patients with major depressive disorder. Psychopharmacol. Bull. 1993, 29:201-206.
2. Barefoot J.C., Helms M.J., Mark D.B., Blumenthal J.A., Califf R.M., Haney T.L., O'Connor C.M., Siegler I.C., Williams R.B. Depression and long-term mortality risk in patients with coronary artery disease. Am. J. Cardiol. 1996, 78:613-617.
3. Benarroch E. Autonomic-mediated immunomodulation and potential clinical relevance. Neurology 2009, 73:236-242.
4. Berntson G.G., Bigger J.T., Eckberg D.L., Grossman P., Kaufmann P.G., Malik M., Nagaraja H.N., Porges S.W., Saul J.P., Stone P.H., van der Molen M.W. Heart rate variability: origins, methods, and interpretive caveats. Psychophysiology 1997, 34:623-648.
5. Bhattacharyya M.R., Whitehead D., Rakhit R., Steptoe A. Depressed mood, positive affect, and heart rate variability in patients with suspected coronary artery disease. Psychosom. Med. 2008, 70:1020-1027.
6. Bigger J.T., Fleiss J.L., Steinman R.C., Rolnitzky L.M., Kleiger R.E., Rottman J.N. Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation 1992, 85:164-171.
7. Bigger J.T., Fleiss J.L., Rolnitzky L.M., Steinman R.C. Frequency domain measures of heart period variability to assess risk late after myocardial infarction. J. Am. Coll. Cardiol. 1993, 21:729-736.
8. Bosch N.M., Riese H., Ormel J., Verhulst F., Oldehinkel A.J. Stressful life events and depressive symptoms in young adolescents: modulation by respiratory sinus arrhythmia? The TRAILS study. Biol. Psychol. 2009, 81:40-47.
9. Carney R.M., Freedland K.E. Depression and heart rate variability in patients with coronary heart disease. Cleve. Clin. J. Med. 2009, 76:S13-S17.
10. Carney R.M., Freedland K.E., Stein P.K., Skala J.A., Hoffman P., Jaffe A.S. Change in heart rate and heart rate variability during treatment for depression in patients with coronary heart disease. Psychosom. Med. 2000, 62:639-647.
11. Carney R.M., Blumenthal J.A., Stein P.K., Watkins L., Catellier D., Berkman L.F., Czajkowski S.M., O'Connor C., Stone P.H., Freedland K.E. Depression, heart rate variability, and acute myocardial infarction. Circulation 2001, 104:2024-2028.
12. Carney R.M., Blumenthal J.A., Freedland K.E., Stein P.K., Howells W.B., Berkman L.F., Watkins L.L., Czajkowski S.M., Hayano J., Domitrovich P.P., Jaffe A.S. Low heart rate variability and the effect of depression on post-myocardial infarction mortality. Arch. Intern. Med. 2005, 165:1486-1491.
13. Carney R.M., Freedland K.E., Veith R.C. Depression, the autonomic nervous system, and coronary heart disease. Psychosom. Med. 2005, 67(Suppl 1):S29-S33.
14. Carney R.M., Freedland K.E., Stein P.K., Howells W.B., Berkman L.F., Watkins L.L., Czajkowski S.M., Hayano J., Domitrovich P.P., Jaffe A.S. Heart rate variability and markers of inflammation and coagulation in depressed patients with coronary heart disease. J. Psychosom. Res. 2007, 62:463-467.
15. Carroll D., Phillips A.C., Hunt K., Der G. Symptoms of depression and cardiovascular reactions to acute psychological stress: evidence from a population study. Biol. Psychol. 2007, 75:68-74.
16. Charney D., Heninger G., Sternberg D., Hafstad K., Giddings S., Landis H. Adrenergic receptor sensitivity in depression. Arch. Gen. Psychiatry 1982, 39:290-294.
17. Chen L.S., Zhou S., Fishbein M.C., Chen P.S. New perspectives on the role of autonomic nervous system in the genesis of arrhythmias. J. Cardiovasc. Electrophysiol. 2007, 18:123-127.
18. Chida Y., Hamer M. Chronic psychosocial factors and acute physiological responses to laboratory-induced stress in healthy populations: a quantitative review of 30years of investigations. Psychol. Bull. 2008, 134:829-885.
19. Chowdhary S., Vaile J.C., Fletcher J., Ross H.F., Coote J.H., Townend J.N. Nitric oxide and cardiac autonomic control in humans. Hypertension 2000, 36:264-269.
20. Conrad A., Wilhelm F.H., Roth W.T., Spiegel D., Taylor C.B. Circadian affective, cardiopulmonary, and cortisol variability in depressed and nondepressed individuals at risk for cardiovascular disease. J. Psychiatr. Res. 2008, 42:769-777.
21. Cook S., Togni M., Schaub M.C., Wenaweser P., Hess O.M. High heart rate: a cardiovascular risk factor?. Eur. Heart J. 2006, 27:2387-2393.
22. Cooke J.P. Asymmetrical dimethylarginine. The uber marker?. Circulation 2004, 109:1813-1819.
23. Davidson J., Watkins L., Owens M., Krulewicz S., Connor K., Carpenter D., Krishnan R., Nemeroff C. Effects of paroxetine and venlafaxine XR on heart rate variability in depression. J. Clin. Psychopharmacol. 2005, 25:480-484.
24. De Gennaro Colonna V., Bianchi M., Pascale V., Ferrario P., Morelli F., Pascale W., Tomasoni L., Turiel M. Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule. Med. Sci. Monit. 2009, 15:RA91-RA101.
25. de Jonge P., Mangano D., Whooley M.A. Differential association of cognitive and somatic depressive symptoms with heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study. Psychosom. Med. 2007, 69:735-739.
26. de Jonge P., Rosmalen J.G., Kema I.P., Doornbos B., van Melle J.P., Pouwer F., Kupper N. Psychophysiological biomarkers explaining the association between depression and prognosis in coronary artery patients: A critical review of the literature. Neurosci. Biobehav. Rev. 2009, Electronic publication ahead of print.
27. Edge J., Bishop D., Goodman C., Dawson B. Effects of high- and moderate-intensity training on metabolism and repeated sprints. Med. Sci. Sports Exerc. 2005, 37:1975-1982.
28. Francis J.L., Weinstein A.A., Krantz D.S., Haigney M.C., Stein P.K., Stone P.H., Gottdiener J.S., Kop W.J. Association between symptoms of depression and anxiety with heart rate variability in patients with implantable cardioverter defibrillators. Psychosom. Med. 2009, 71:821-827.
29. Frasure-Smith N., Lespérance F., Talajic M. Depression and 18-month prognosis after myocardial infarction. Circulation 1995, 91:999-1005.
30. Frasure-Smith N., Lespérance F., Irwin M.R., Talajic M., Pollock B.G. The relationships among heart rate variability, inflammatory markers and depression in coronary heart disease patients. Brain Behav. Immun. 2009, 23:1140-1147.
31. Freemantle N., Cleland J., Young P., Mason J., Harrison J. Beta blockade after myocardial infarction. Systematic review and meta regression analysis. BMJ 1999, 318:1730-1737.
32. Gehi A., Mangano D., Pipkin S., Browner W.S., Whooley M.A. Depression and heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study. Arch. Gen. Psychiatry 2005, 62:661-666.
33. Giannoglou G.D., Chatzizisis Y.S., Zamboulis C., Parcharidis G.E., Mikhailidis D.P., Louridas G.E. Elevated heart rate and atherosclerosis: an overview of the pathogenetic mechanisms. Int. J. Cardiol. 2008, 126:302-312.
34. Glassman A.H., Bigger J.T., Gaffney M. Psychiatric characteristics associated with long-term mortality among 361 patients having an acute coronary syndrome and major depression: seven-year follow-up of SADHART participants. Arch. Gen. Psych. 2009, 66:1022-1029.
35. Goedhart A.D., van der Sluis S., Houtveen J.H., Willemsen G., de Geus E.J. Comparison of time and frequency domain measures of RSA in ambulatory recordings. Psychophysiology 2007, 44:203-215.
36. Gold P.W., Chrousos G.P. Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol. Psychiatry 2002, 7:254-275.
37. Grossman P., Taylor E.W. Toward understanding respiratory sinus arrhythmia: relations to cardiac vagal tone, evolution and biobehavioral functions. Biol. Psychol. 2007, 74:263-285.
38. Guinjoan S.M., de Guevara M.S., Correa C., Schauffele S.I., Nicola-Siri L., Fahrer R.D., Ortiz-Frágola E., Martínez-Martínez J.A., Cardinali D.P. Cardiac parasympathetic dysfunction related to depression in older adults with acute coronary syndromes. J. Psychosom. Res. 2004, 56:83-88.
39. Guinjoan S.M., Castro M.N., Vigo D.E., Weidema H., Berbara C., Fahrer R.D., Grancelli H., Nogues M., Leiguarda R.C., Cardinali D.P. Depressive symptoms are related to decreased low-frequency heart rate variability in older adults with decompensated heart failure. Neuropsychobiology 2007, 55:219-224.
40. Hance M., Carney R.M., Freedland K.E., Skala J. Depression in patients with coronary heart disease. A 12-month follow-up. Gen. Hosp. Psychiatry 1996, 18:61-65.
41. Hayes S.N. Preventing cardiovascular disease in women. Am. Fam. Physician 2006, 74:1331-1334.
42. Heffernan K.S., Jae S.Y., Vieira V.J., Iwamoto G.A., Wilund K.R., Woods J.A., Fernhall B. C-reactive protein and cardiac vagal activity following resistance exercise training in young African-American and white men. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009, 296:R1098-R1105.
43. Hughes J.W., York K.M., Li Q., Freedland K.E., Carney R.M., Sheps D.S. Depressive symptoms predict heart rate recovery after exercise treadmill testing in patients with coronary artery disease: results from the Psychophysiological Investigation of Myocardial Ischemia study. Psychosom. Med. 2008, 70:456-460.
44. Imai K., Sato H., Hori M., Yokoyama H., Imai K., Morikawa M., Takeda H., Inoue M., Kamada T. Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. J. Am. Coll. Cardiol. 1994, 24:1529-1535.
45. Jeanningros R., Mazzola P., Azorin J., Samuelian-Massa C., Tissot R. Beta-adrenoceptor density of intact mononuclear leukocytes in subgroups of depressive disorders. Biol. Psychiatry 1991, 15:789-798.
46. Jindal R.D., Vasko R.C., Jennings J.R., Fasiczka A.L., Thase M.E., Reynolds C.F. Heart rate variability in depressed elderly. Heart rate variability in depressed elderly. Am. J. Geriatr. Psychiatry 2008, 16:861-866.
47. Kamphuis M.D., Geerlings M.I., Dekker J.M., Giampaoli S., Nissinen A., Grobbee D.E., Kromhout D. Autonomic dysfunction: a link between depression and cardiovascular mortality? The FINE Study. Eur. J. Cardiovasc. Prev. Rehabil. 2007, 14:796-802.
48. Kamphuis M.D., Geerlings M.I., Tijhuis M.A., Giampaoli S., Nissinen A., Grobbee D.E., Kromhout D. Physical inactivity, depression, and risk of cardiovascular mortality. Med. Sci. Sports Exerc. 2007, 39:1693-1699.
49. Kannel W.B., Kannel C., Paffenbarger R.S., Cupples L.A. Heart rate and cardiovascular mortality: the Framingham Study. Am. Heart J. 1987, 113:1489-1494.
50. Karpyak V.M., Rasmussen K.G., Hammill S.C., Mrazek D.A. Changes in heart rate variability in response to treatment with electroconvulsive therapy. J. ECT 2004, 20:81-88.
51. Kesek M., Franklin K.A., Sahlin C., Lindberg E. Heart rate variability during sleep and sleep apnoea in a population based study of 387 women. Clin. Physiol. Funct. Imaging 2009, 29:309-315.
52. Khaykin Y., Dorian P., Baker B., Shapiro C., Sandor P., Mironov D., Irvine J., Newman D. Autonomic correlates of antidepressant treatment using heart-rate variability analysis. Can. J. Psychiatry 1998, 43:183-642.
53. Kibler J.L., Ma M. Depressive symptoms and cardiovascular reactivity to laboratory behavioral stress. Int. J. Behav. Med. 2004, 11:81-87.
54. Kikuchi M., Hanaoka A., Kidani T., Remijn G.G., Minabe Y., Munesue T., Kohsino Y. Heart rate variability in drug-naïve patients with panic disorder and major depressive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry 2009, 33:1474-1478.
55. Kleiger R.E., Miller P.J., Bigger T.J., Moss A.J. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am. J. Cardiol. 1987, 59:256-262. Multicenter Post-Infarction Research Group.
56. Lehofer M., Moser M., Hoehn-Saric R., McLeod D., Liebmann P., Drnovsek B., Egner S., Hildebrandt G., Zapotoczky H.G. Major depression and cardiac autonomic control. Biol. Psychiatry 1997, 42:914-919.
57. Lespérance F., Frasure-Smith N., Talajic M., Bourassa M.G. Five-year risk of cardiac mortality in relation to initial severity and one-year changes in depression symptoms after myocardial infarction. Circulation 2002, 105:1049-1053.
58. Levine H.J. Rest heart rate and life expectancy. J. Am. Coll. Cardiol. 1997, 30:1104-1106.
59. Licht C.M., de Geus E.J., van Dyck R., Penninx B.W. Association between anxiety disorders and heart rate variability in The Netherlands Study of Depression and Anxiety (NESDA). Psychosom. Med. 2009, 71:508-518.
60. Lopez-Sendon J., Swedberg K., McMurray J., Tamargo J., Maggioni A.P., Dargie H., Tendera M., Waagstein F., Kjekshus J., Lechat P., Torp-Pedersen C. Expert consensus document on beta-adrenergic receptor blockers. Eur. Heart J. 2004, 25:1341-1362.
61. Lown B., Verrier R.L. Neural activity and ventricular fibrillation. N. Engl. J. Med. 1976, 294:1165-1170.
62. Lykke J.A., Tarnow L., Parving H.H., Hilsted J. A combined abnormality in heart rate variation and QT corrected interval is a strong predictor of cardiovascular death in type 1 diabetes. Scand. J. Clin. Lab. Investig. 2008, 12:1-6.
63. Martens E.J., Nyklícek I., Szabó B.M., Kupper N. Depression and anxiety as predictors of heart rate variability after myocardial infarction. Psychol. Med. 2008, 38:375-383.
64. Maser R.E., Mitchell B.D., Vinik A.I., Freeman R. The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. Diab. Care 2003, 26:1895-1901.
65. Matthews S.C., Nelesen R.A., Dimsdale J.E. Depressive symptoms are associated with increased systemic vascular resistance to stress. Psychosom. Med. 2005, 67:509-513.
66. Michalsen A., Knoblauch N.T., Lehmann N., Grossman P., Kerkhoff G., Wilhelm F.H., Moebus S., Konstantinides S., Binder L., Heusch G., Siffert W., Budde T., Dobos G.J. Effects of lifestyle modification on the progression of coronary atherosclerosis, autonomic function, and angina-the role of GNB3 C825T polymorphism. Am. Heart J. 2006, 151:870-877.
67. Neumann S.A., Lawrence E.C., Jennings J.R., Ferrell R.E., Manuck S.B. Heart rate variability is associated with polymorphic variation in the choline transporter gene. Psychosom. Med. 2005, 67:168-171.
68. Nicholson A., Kuper H., Hemingway H. Depression as an etiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146, 538 participants in 4 observational studies. Eur. Heart J. 2006, 27:2763-2774.
69. Nishime E.O., Cole C.R., Blackstone E.H., Pashkow F.J., Lauer M.S. Heart rate recovery and treadmill exercise score as predictors of mortality in patients referred for exercise ECG. JAMA 2000, 284:1392-1398.
70. Nolan R.P., Jong P., Barry-Bianchi S.M., Tanaka T.H., Floras J.S. Effects of drug, biobehavioral and exercise therapies on heart rate variability in coronary artery disease: a systematic review. Eur. J. Cardiovasc. Prev. Rehabil. 2008, 15:386-396.
71. Pitzalis M.V., Iacoviello M., Todarello O., Fioretti A., Guida P., Massari F., Mastropasqua F., Russo G.D., Rizzon P. Depression but not anxiety influences the autonomic control of heart rate after myocardial infarction. Am. Heart J. 2001, 141:765-771.
72. Rees K., Bennett P., West R., Davey Smith G., Ebrahim S. Psychological interventions for coronary heart disease. Cochrane Database Syst. Rev. 2004, 2. CD002902.
73. Ritz T. Studying noninvasive indices of vagal control: the need for respiratory control and the problem of target specificity. Biol. Psychol. 2009, 80:158-168.
74. Ritz T., Dahme B. Implementation and interpretation of respiratory sinus arrhythmia measures in psychosomatic medicine: practice against better evidence?. Psychosom. Med. 2006, 68:617-627.
75. Rottenberg J., Wilhelm F.H., Gross J.J., Gotlib I.H. Respiratory sinus arrhythmia as a predictor of outcome in major depressive disorder. J. Affect. Disord. 2002, 71:265-272.
76. Rottenberg J., Chambers A.S., Allen J.J., Manber R. Cardiac vagal control in the severity and course of depression: the importance of symptomatic heterogeneity. J. Affect. Disord. 2007, 103:173-179.
77. Rottenberg J., Clift A., Bolden S., Salomon K. RSA fluctuation in major depressive disorder. Psychophysiology 2007, 44:450-458.
78. Rugulies R. Depression as a predictor for coronary heart disease a review and meta-analysis. Am. J. Prev. Med. 2002, 23:51-61.
79. Salomon K., Clift A., Karlsdóttir M., Rottenberg J. Major depressive disorder is associated with attenuated cardiovascular reactivity and impaired recovery among those free of cardiovascular disease. Health Psychol. 2009, 28:157-165.
80. Sastre M., Guimon J., Garcia-Sevilla J. Relationships between ß- and 2-adrenoreceptors and G coupling proteins in the human brain: effects of age and suicide. Brain Res. 2001, 898:242-255.
81. Schildkraut J. The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am. J. Psychiatry 1965, 122:127-130.
82. Schwerdtfeger A., Friedrich-Mai P. Social interaction moderates the relationship between depressive mood and heart rate variability: evidence from an ambulatory monitoring study. Health Psychol. 2009, 28:3501-3509.
83. Singh B.N. Increased heart rate as a risk factor for cardiovascular disease. Eur. Heart J. Suppl. 2003, 5:G3-G9.
84. Sloan R.P., McCreath H., Tracey K.J., Sidney S., Liu K., Seeman T. RR interval variability is inversely related to inflammatory markers: the CARDIA study. Mol. Med. 2007, 13:178-184.
85. Stein P.K., Carney R.M., Freedland K.E., Skala J.A., Jaffe A.S., Kleiger R.E., Rottman J.N. Severe depression is associated with markedly reduced heart rate variability in patients with stable coronary heart disease. J. Psychosom. Res. 2000, 48:493-500.
86. Stein P.K., Barzilay J.I., Chaves P.H., Mistretta S.Q., Domitrovich P.P., Gottdiener J.S., Rich M.W., Kleiger R.E. Novel measures of heart rate variability predict cardiovascular mortality in older adults independent of traditional cardiovascular risk factors: the Cardiovascular Health Study (CHS). J. Cardiovasc. Electrophysiol. 2008, 19:1169-1174.
87. Strachowski D., Khaylis A., Conrad A., Neri E., Spiegel D., Taylor C.B. The effects of cognitive behavior therapy on depression in older patients with cardiovascular risk. Depress. Anxiety 2008, 25. E1-10j.
88. Strike P.C., Steptoe A. Psychosocial factors in the development of coronary artery disease. Prog. Cardiovasc. Dis. 2004, 46:337-347.
89. Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Circulation 1996, 93:1043-1065. Task Force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology.
90. Taylor C.B., Conrad A., Wilhelm F.H., Neri E., Delorenzo A., Kramer M.A., Giese-Davis J., Roth W.T., Oka R., Cooke J.P., Kraemer H., Spiegel D. Psychophysiological and cortisol responses to psychological stress in depressed and non-depressed older men and women with elevated CVD risk. Psychosom. Med. 2006, 68:538-546.
91. Taylor C.B., Conrad A., Wilhelm F.H., Strachowski D., Khaylis A., Neri E., Giese-Davis J., Roth W.T., Cooke J.P., Kraemer H., Spiegel D. Does improving mood in depressed patients alter factors that may affect cardiovascular disease risk?. J. Psychiatr. Res. 2009, 43:1246-1252.
92. Tracey K.J. The inflammatory reflex. Nature 2002, 420(6917):853-859.
93. Vaccarino V., Lampert R., Bremner J.D., Lee F., Su S., Maisano C., Murrah N.V., Jones L., Jawed F., Afzal N., Ashraf A., Goldberg J. Depressive symptoms and heart rate variability: evidence for a shared genetic substrate in a study of twins. Psychosom. Med. 2008, 70:628-636.
94. Vaishnav S., Stevenson R., Marchant B., Lagi K., Ranjadayalan K., Timmis A.D. Relation between heart rate variability early after acute myocardial infarction and long-term mortality. Am. J. Cardiol. 1994, 73:653-657.
95. van der Kooy K.G., van Hout H.P., van Marwijk H.W., de Haan M., Stehouwer C.D., Beekman A.T. Differences in heart rate variability between depressed and non-depressed elderly. Int. J. Geriatr. Psychiatry 2006, 21:147-150.
96. Van Zyl L.T., Hasegawa T., Katsutaro N. Effects of antidepressant treatment on heart rate variability in major depression: a quantitative review. Biopsychosoc. Med. 2008, 2:12.
97. Vinik A.I., Maser R.E., Mitchell B.D., Freeman R. Diabetic autonomic neuropathy. Diab. Care 2003, 26:1553-1579.
98. Whooley M.A., de Jonge P., Vittinghoff E., Otte C., Moos R., Carney R.M., Ali S., Dowray S., Na B., Feldman M.D., Schiller N.B., Browner W.S. Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. JAMA 2008, 300:2379-2388.
99. Wilhelm F.H., Grossman P., Roth W.T. Analysis of cardiovascular regulation. Biomed. Sci. Instrum. 1999, 35:135-140.
100. Wilhelm F.H., Grossman P., Coyle M.A. Improving estimation of cardiac vagal tone during spontaneous breathing using a paced breathing calibration. Biomed. Sci. Instrum. 2004, 40:317-324.
101. Wilhelm F.H., Grossman P., Roth W.T. Assessment of heart rate variability during alterations in stress: complex demodulation vs. spectral analysis. Biomed. Sci. Instrum. 2005, 41:346-351.
102. Yeragani V.K., Pesce V., Jayaraman A., Roose S. Major depression with ischemic heart disease: effects of paroxetine and nortriptyline on long-term heart rate variability measures. Biol. Psychiatry 2002, 52:418-429.
103. York K.M., Hassan M., Li Q., Li H., Fillingim R.B., Sheps D.S. Coronary artery disease and depression: patients with more depressive symptoms have lower cardiovascular reactivity during laboratory-induced mental stress. Psychosom. Med. 2007, 69:521-528.
104. Zaaimi B., Grebe R., Berquin P., Wallois F. Vagus nerve stimulation induces changes in respiratory sinus arrhythmia of epileptic children during sleep. Epilepsia 2009, 50:2473-2480.