Relationships between β- and α2-adrenoceptors and G coupling proteins in the human brain: Effects of age and suicide

Brain Research

Volumn 898, Issue 2, 2001, Pages 242-255

  Sastre, Magdalena ^a   Guimón, José ^b   García Sevilla, Jesús A ^a,b  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

2A Adrenoceptor; Adrenoceptor; Aging; G coupling protein; Human brain; Suicide

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; ALPHA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BRIMONIDINE; CLONIDINE; GUANINE NUCLEOTIDE BINDING PROTEIN; RECEPTOR SUBTYPE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; PROPANOLAMINE DERIVATIVE;

ADULT; AGING; ARTICLE; AUTOPSY; BINDING AFFINITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; HUMAN; HUMAN TISSUE; MALE; NEUROCHEMISTRY; PRIORITY JOURNAL; RECEPTOR DENSITY; SUICIDE; ADOLESCENT; AGED; BRAIN; BRAIN LEVEL; CHILD; DEPRESSION; INFANT; METABOLISM; MIDDLE AGED; NEWBORN; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; RADIOASSAY;

ADOLESCENT; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; AGED, 80 AND OVER; AGING; BRAIN; BRAIN CHEMISTRY; CHILD; CHILD, PRESCHOOL; DEPRESSION; FEMALE; GTP-BINDING PROTEINS; HUMANS; INFANT; INFANT, NEWBORN; MALE; MIDDLE AGED; PROPANOLAMINES; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, ADRENERGIC, BETA; SUICIDE;

EID: 0035917312     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02190-4     Document Type: Article

References (90)

1. Catalytic unit of adenylate cyclase: Reduced activity in aged-human lymphocytes
2. The effect of α-adrenergic manipulation on the 24 hour pattern of cortisol secretion in man
3. 2 and β-adrenergic receptor binding sites in the brain of suicide victims
4. 12 and its distribution
5. G proteins, adenylyl cyclase and related phosphoproteins in the developing rat heart
6. 2-adrenoceptor subtypes in rat brain
7. Regionally selective increases in β-adrenergic receptor density in the brains of suicide victims
8. Adrenergic and serotonergic receptors in aged monkey neocortex
9. Age-dependent decrease of β-adrenoceptor function in human right atrium
10. A rapid filtration assay for soluble receptor using polythylenimine-treated filters
11. 2A-adrenoceptor agonist binding site in the postmortem brain of depressed suicide victims
12. Adrenergic receptors in Parkinson's disease
13. Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims
14. Neurotransmitter receptors and monoamine metabolites in the brain of patients with Alzheimer-type dementia and depression and suicides
15. 3H]CGP 12177
16. Brain β-adrenoceptor binding sites in antidepressant-free depressed suicide victims
17. 2-Adrenoceptor binding sites in cortical samples from depressed suicide victims
18. Brain β-adrenoceptor binding sites in depressed suicide victims: Effects of antidepressant treatment
19. Beta-adrenoceptors in human pineal glands are unaltered in depressed suicides
20. Brain alpha-adrenoceptors in depressed suicides
21. 2-adrenoceptors
22. Development of β-adrenergic receptor and G protein messenger RNA in rat brain
23. β-adrenergic receptor distribution in human and rat hippocampal formation: Marked species differences
24. Increased density of guanine nucleotide-binding (G) proteins in the postmortem brain of heroin addicts
25. Correlation between beta- and alpha-adrenergic receptor concentrations in human placenta
26. Postmortem neurochemical studies in depression
27. Age-related changes in adenosine and β-adrenoceptor responsiveness of vascular smooth muscle in man
28. Platelet alpha-2 adrenergic receptors in major depressive disorder. Binding of tritiated clonidine before and after tricyclic antidepressant drug treatment
29. 2-adrenoceptors in major affective disorder. Effect on long-term lithium carbonate treatment
30. 3H](-)adrenaline to platelets of depressed patients with melancholia: Effect of long-term clomipramine treatment
31. Lack of an effect on beta-adrenoceptor-mediated lipolysis in isolated human lipocytes
32. Adrenergic receptors in the cerebellum of olivopontocerebellar atrophy
33. Coupling efficiency of brain beta-adrenergic receptors to Gs protein in suicide, alcoholism and control subjects
34. Age-related alterations on GTP binding proteins in human brain
35. Alternative splicing of the mRNA encoding the subunits of the Go GTP-binding protein during brain development and in neuronal cell lines
36. Prejunctional β-adrenoceptors in rabbit pulmonary artery and mouse atria: Effect of α-adrenoceptor blockade and phosphodiesterase inhibition
37. Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium
38. Distribution of beta-adrenergic receptor subtypes in human postmortem brain: Alterations in limbic regions of schizophrenics
39. 2-receptors in prefrontal cortex and hippocampus
40. Down-regulation of β-adrenoceptors by isoprenaline in cultured human lymphoblast cells
41. 2-adrenoceptors coupling with GTP-binding proteins in the rat telencephalon
42. 2-adrenoceptors of cerebral cortical membranes in rats
43. β-adrenergic receptor binding in human and rat hypothalamus
44. β-Adrenergic receptor binding in frontal cortex of suicide victims
45. Lack of pineal beta-adrenergic receptor alterations in suicide victims with major depression
46. Protein measurement with the Folin phenol reagent
47. 2-adrenergic receptor involves multiple subsites
48. 2 and β-adrenergic receptor binding in the frontal cortices of suicide victims
49. A practical computer based approach to the analysis of radioligand binding experiments
50. 2-Adrenoceptors in the brain of suicide victims: Increased receptor density associated with major depression
51. Human brain receptor alterations in suicide victims
52. Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins
53. sα protein mRNA in rat ventricular myocardium with aging
54. Age-related changes in synaptic neurochemistry
55. LIGAND: A versatile computerized approach of characterization of ligand-binding systems
56. Age-related decrease in responsiveness to L-DOPA is not due to changes in dopamine receptor mRNAs or G protein mRNAs
57. 2- and β-adrenergic receptors in rat cerebral cortical membranes: Clonidine-induced reduction in agonist and antagonist affinity for β-adrenergic receptors
58. Quantitative analysis of the selectivity of radioligands for subtypes of beta adrenergic receptors
59. 3H]clonidine binding in rats
60. 2-adrenoceptor-GTP binding regulatory protein-adenylate cyclase system in cerebral cortical membranes of adult and senescent rats
61. Pathophysiology of the locus coeruleus in suicide
62. 2-adrenoceptors: An autoradiographic study in human brain
63. β-adrenoceptor subtypes in the human brain: Autoradiographic localization
64. β-adrenoceptor autoradiographic labelling in human brain: Subtype distribution, effects of age and post mortem delay and modifications in Alzheimer's disease
65. 3H]para-aminoclonidine binding to platelet adrenoceptors in depression
66. 3H-para-aminoclonidine binding to platelet purified plasma membranes from depressed patients
67. 2-adrenergic receptor density in the cerebellum of aging rats
68. The influence of animal age on beta-adrenoceptor density and function in tracheal airway smooth muscle
69. 3H]dihydroalprenolol
70. Alterations in myocardial signal transduction due to aging and chronic dynamic exercise
71. 2 with monoamine oxidase-B sites
72. 1 proteins in the human brain: Ratio of high-affinity agonist sites to antagonist sites and effect of age
73. 2-adrenoceptors and monoamine oxidase B in the brains of suicide victims
74. β-adrenergic function in aging
75. Changes in β-adrenergic receptor subtypes in Alzheimer-type dementia
76. Forskolin binding sites and G-protein immunoreactivity in rat hearts during aging
77. 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: In situ identification with Gα C-terminal antibodies
78. β-adrenergic receptor binding in frontal cortex of suicide victims
79. 3H-imipramine binding and plasma cortisol level in depression
80. 1 adrenoceptor
81. 2-adrenergic receptors in rat liver
82. A quantitative study of the pigmented neurons in the nuclei locus coeruleus and subcoeruleus in man as related to aging
83. 2 adrenoceptors of mouse brain cortex
84. 1-adrenoceptor density in brain cortex of aging mice
85. 2-adrenergic receptors in the brain assessed by quantitative autoradiography
86. α-adrenergic receptors modulate β-receptor affinity in rat kidney membranes
87. β-adrenoceptor binding defects in cell lines from families with manic-depressive disorders
88. Age-associated reductions in cardiac beta1- and beta2-adrenergic responses without changes in inhibitory G proteins or receptor kinases
89. Maturational and aging effects on guanine nucleotide binding protein immunoreactivity in human brain