Comment on M.V. Evans and J.C. Caldwell: Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling of in vivo gas uptake data exposure in female B6C3F1 mice, Toxicol. Appl. Pharmacol., 244, 280-290, 2010

Toxicology and Applied Pharmacology

Volumn 248, Issue 1, 2010, Pages 63-64

  Anders, M W ^a   Andersen, Melvin E ^b   Clewell, Harvey J ^b   Gargas, Michael L ^c   Guengerich, F Peter ^d   Reitz, Richard H ^e  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^c AIR FORCE RESEARCH LABORATORY   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e RHR Toxicology Consulting   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; CYTOCHROME P450 2E1; DICHLOROMETHANE; GLUTATHIONE TRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CARCINOGENICITY; CATALYSIS; CONTROLLED STUDY; ENZYME SUBSTRATE COMPLEX; FEMALE; GLUTATHIONE METABOLISM; LETTER; MOUSE; NONHUMAN; RISK ASSESSMENT; TOXICITY TESTING; TOXICOKINETICS; XENOBIOTIC METABOLISM; ANIMAL; BIOLOGICAL MODEL; METABOLISM; PROCEDURES; TOXICITY;

ANIMALS; CYTOCHROME P-450 CYP2E1; FEMALE; GLUTATHIONE TRANSFERASE; METHYLENE CHLORIDE; MICE; MODELS, BIOLOGICAL; RISK ASSESSMENT;

MUS;

EID: 77956412012     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.07.012     Document Type: Letter

References (9)

1. Andersen M.E., Clewell H.J., Gargas M.L., Smith F.A., Reitz R.H. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. Pharmacol. 1987, 87:185-205.
2. Chowdhury G., Calcutt M.W., Guengerich F.P. Oxidation of N-nitrosodimethylamine and N-nitrosodiethylamine by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps. J. Biol. Chem. 2010, 285:8031-8044.
3. Collom S.L., Laddusaw R.M., Burch A.M., Kuzmic P., Perry M.D., Miller G.P. CYP2E1 substrate inhibition: mechanistic interpretation through an effector site for monocyclic compounds. J. Biol. Chem. 2008, 283:3487-3496.
4. Gargas M.L., Clewell H.J., Andersen M.E. Metabolism of inhaled dihalomethanes in vivo: differentiation of kinetic constants for two independent pathways. Toxicol. Appl. Pharmacol. 1986, 82:211-223.
5. Harrelson J.P., Atkins W.M., Nelson S.D. Multiple-ligand binding in CYP2A6: probing mechanisms of cytochrome P450 cooperativity by assessing substrate dynamics. Biochemistry 2008, 47:2978-2988.
6. Harrelson J.P., Henne K.R., Alonso D.O., Nelson S.D. A comparison of substrate dynamics in human CYP2E1 and CYP2A6. Biochem. Biophys. Res. Commun. 2007, 352:843-849.
7. Serota D.G., Thakur A.K., Ulland B.M., et al. A two-year drinking water study of dichloromethane in rodents: II. Mice. Food Chem. Toxicol. 1986, 24(9):959-963.
8. Watanabe K., Guengerich F.P. Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane. Chem. Res. Toxicol. 2006, 19:1091-1096.
9. Watanabe K., Liberman R.G., Skipper P.L., Tannenbaum S.R., Guengerich F.P. Analysis of DNA adducts formed in vivo in rats and mice from 1, 2-dibromoethane, 1, 2- dichloromethane, dibromomethane, and dichloromethane using HPLC/accelerator mass spectrometry and relevance to risk estimates. Chem. Res. Toxicol. 2007, 20:1594-1600.