Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation

Toxicology and Applied Pharmacology

Volumn 248, Issue 1, 2010, Pages 38-44

  Richardson, Terrilyn A ^a,b   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

3 methylcholanthrene; Aroclor 1254; Phenobarbital; Pregnenolone 16 carbonitrile; Thyroid stimulating hormone; Thyroxine T4; UDP glucuronosyltransferases, Ugt1a deficeint Gunn rat

Indexed keywords

16ALPHA CYANOPREGNENOLONE; 3 METHYLCHOLANTHRENE; AROCLOR 1254; GLUCURONOSYLTRANSFERASE; LIOTHYRONINE; PHENOBARBITAL; THYROTROPIN; THYROXINE; UDP-GLUCURONOSYLTRANSFERASE, UGT1A7; UGT1A1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INDUCTION; GLUCURONIDATION; LIOTHYRONINE BLOOD LEVEL; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; RAT; THYROID FOLLICLE CELL; THYROID HORMONE METABOLISM; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TOXICOKINETICS; XENOBIOTIC METABOLISM; ANIMAL; BLOOD; COMPARATIVE STUDY; DRUG EFFECTS; ENZYMOLOGY; GUNN RAT; LIVER; LIVER MICROSOME; METABOLISM; THYROID GLAND; TOXICITY; WISTAR RAT;

ANIMALS; CELL PROLIFERATION; CHLORODIPHENYL (54% CHLORINE); GLUCURONOSYLTRANSFERASE; LIVER; MALE; METHYLCHOLANTHRENE; MICROSOMES, LIVER; PREGNENOLONE CARBONITRILE; RATS; RATS, GUNN; RATS, WISTAR; THYROID GLAND; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

RATTUS NORVEGICUS;

EID: 77956401520     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.07.010     Document Type: Article

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