Autophagy plays an important role in Sunitinib-mediated cell death in H9c2 cardiac muscle cells

Toxicology and Applied Pharmacology

Volumn 248, Issue 1, 2010, Pages 20-27

  Zhao, Yuqin ^a   Xue, Tao ^a   Yang, Xiaochun ^a   Zhu, Hong ^a   Ding, Xiaofei ^a   Lou, Liming ^a   Lu, Wei ^c   Yang, Bo ^a   He, Qiaojun ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

Antitumor drugs; Autophagy; Cardiotoxicity; Sunitinib

Indexed keywords

BECLIN 1; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SUNITINIB; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, RAT; INDOLE DERIVATIVE; LC3 PROTEIN, RAT; MICROTUBULE ASSOCIATED PROTEIN; PYRROLE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CARDIOTOXICITY; CELL DEATH; CELL PROTECTION; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME DEGRADATION; NONHUMAN; RAT; RNA INTERFERENCE; ANIMAL; CELL LINE; CELL PROLIFERATION; DRUG EFFECTS; GENETICS; HEART MUSCLE CELL; METABOLISM; TOXICITY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE; CELL PROLIFERATION; INDOLES; MICROTUBULE-ASSOCIATED PROTEINS; MYOCYTES, CARDIAC; PYRROLES; RATS; RNA INTERFERENCE;

EID: 77956396096     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.07.007     Document Type: Article

References (35)

1. Akazawa H., Komazaki S., Shimomura H., Terasaki F., Zou Y., Takano H., Nagai T., Komuro I. Diphtheria toxin-induced autophagic cardiomyocyte death plays a pathogenic role in mouse model of heart failure. J. Biol. Chem. 2004, 279:41095-41103.
2. Arthur C.R., Gupton J.T., Kellogg G.E., Yeudall W.A., Cabot M.C., Newsham I.F., Gewirtz D.A. Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison. Biochem. Pharmacol. 2007, 74:981-991.
3. Chow L.Q., Eckhardt S.G. Sunitinib: from rational design to clinical efficacy. J. Clin. Oncol. 2007, 25:884-896.
4. Fabian M.A., Biggs W.H., Treiber D.K., Atteridge C.E., Azimioara M.D., Benedetti M.G., Carter T.A., Ciceri P., Edeen P.T., Floyd M., Ford J.M., Galvin M., Gerlach J.L., Grotzfeld R.M., Herrgard S., Insko D.E., Insko M.A., Lai A.G., Lelias J.M., Mehta S.A., Milanov Z.V., Velasco A.M., Wodicka L.M., Patel H.K., Zarrinkar P.P., Lockhart D.J. A small molecule-kinase interaction map for clinical kinase inhibitors. Nat. Biotechnol. 2005, 23:329-336.
5. Gurusamy N., Das D.K. Is autophagy a double-edged sword for the heart?. Acta Physiol Hung. 2009, 96:267-276.
6. Gustafsson A.B., Gottlieb R.A. Autophagy in ischemic heart disease. Circ. Res. 2009, 104:150-158.
7. Hasinoff B.B. The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity. Toxicol. Appl. Pharmacol. 2010, 244:190-195.
8. Hein S., Elsasser A., Kostin S., Zimmermann R., Schaper J. Functional disturbances due to structural remodeling in the failing human heart. Arch. Mal. Coeur Vaiss. 2002, 95:815-820.
9. Hein S., Arnon E., Kostin S., Schonburg M., Elsasser A., Polyakova V., Bauer E.P., Klovekorn W.P., Schaper J. Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation 2003, 107:984-991.
10. Hernandez-Esquivel L., Marin-Hernandez A., Pavon N., Carvajal K., Moreno-Sanchez R. Cardiotoxicity of copper-based antineoplastic drugs casiopeinas is related to inhibition of energy metabolism. Toxicol. Appl. Pharmacol. 2006, 212:79-88.
11. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000, 19:5720-5728.
12. Kang C., Avery L. To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation. Autophagy 2008, 4:82-84.
13. Kerkela R., Grazette L., Yacobi R., Iliescu C., Patten R., Beahm C., Walters B., Shevtsov S., Pesant S., Clubb F.J., Rosenzweig A., Salomon R.N., Van Etten R.A., Alroy J., Durand J.B., Force T. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat. Med. 2006, 12:908-916.
14. Kim D.W., Jo Y.S., Jung H.S., Chung H.K., Song J.H., Park K.C., Park S.H., Hwang J.H., Rha S.Y., Kweon G.R., Lee S.J., Jo K.W., Shong M. An orally administered multitarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibitor of thyroid oncogenic RET/papillary thyroid cancer kinases. J. Clin. Endocrinol. Metab. 2006, 91:4070-4076.
15. Kim J., Klionsky D.J. Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu. Rev. Biochem. 2000, 69:303-342.
16. Klionsky D.J. The correct way to monitor autophagy in higher eukaryotes. Autophagy 2005, 1:65.
17. Kostin S., Pool L., Elsasser A., Hein S., Drexler H.C., Arnon E., Hayakawa Y., Zimmermann R., Bauer E., Klovekorn W.P., Schaper J. Myocytes die by multiple mechanisms in failing human hearts. Circ. Res. 2003, 92:715-724.
18. Krause D.S., Van Etten R.A. Tyrosine kinases as targets for cancer therapy. N Engl J. Med. 2005, 353:172-187.
19. Levine B., Yuan J. Autophagy in cell death: an innocent convict?. J. Clin. Invest. 2005, 115:2679-2688.
20. Liang X.H., Jackson S., Seaman M., Brown K., Kempkes B., Hibshoosh H., Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402:672-676.
21. Mann D.L. Targeted cancer therapeutics: the heartbreak of success. Nat. Med. 2006, 12:881-882.
22. Matsui Y., Takagi H., Qu X., Abdellatif M., Sakoda H., Asano T., Levine B., Sadoshima J. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ. Res. 2007, 100:914-922.
23. Minor R.K., Smith D.L., Sossong A.M., Kaushik S., Poosala S., Spangler E.L., Roth G.S., Lane M., Allison D.B., de Cabo R., Ingram D.K., Mattison J.A. Chronic ingestion of 2-deoxy-D-glucose induces cardiac vacuolization and increases mortality in rats. Toxicol. Appl. Pharmacol. 2010, 243:332-339.
24. Mizushima N. Methods for monitoring autophagy. Int. J. Biochem. Cell Biol. 2004, 36:2491-2502.
25. Mizushima N. The pleiotropic role of autophagy: from protein metabolism to bactericide. Cell Death Differ. 2005, 12(Suppl 2):1535-1541.
26. Morabito A., De Maio E., Di Maio M., Normanno N., Perrone F. Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions. Oncologist 2006, 11:753-764.
27. Nakai A., Yamaguchi O., Takeda T., Higuchi Y., Hikoso S., Taniike M., Omiya S., Mizote I., Matsumura Y., Asahi M., Nishida K., Hori M., Mizushima N., Otsu K. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat. Med. 2007, 13:619-624.
28. Paglin S., Hollister T., Delohery T., Hackett N., McMahill M., Sphicas E., Domingo D., Yahalom J. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res. 2001, 61:439-444.
29. Tannous P., Zhu H., Johnstone J.L., Shelton J.M., Rajasekaran N.S., Benjamin I.J., Nguyen L., Gerard R.D., Levine B., Rothermel B.A., Hill J.A. Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc. Natl Acad. Sci. USA 2008, 105:9745-9750.
30. Telli M.L., Witteles R.M., Fisher G.A., Srinivas S. Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate. Ann. Oncol. 2008, 19:1613-1618.
31. Yan L., Vatner D.E., Kim S.J., Ge H., Masurekar M., Massover W.H., Yang G., Matsui Y., Sadoshima J., Vatner S.F. Autophagy in chronically ischemic myocardium. Proc. Natl Acad. Sci. USA 2005, 102:13807-13812.
32. Yu L., Alva A., Su H., Dutt P., Freundt E., Welsh S., Baehrecke E.H., Lenardo M.J. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004, 304:1500-1502.
33. Yussman M.G., Toyokawa T., Odley A., Lynch R.A., Wu G., Colbert M.C., Aronow B.J., Lorenz J.N., Dorn G.W. Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nat. Med. 2002, 8:725-730.
34. Zhu H., Tannous P., Johnstone J.L., Kong Y., Shelton J.M., Richardson J.A., Le V., Levine B., Rothermel B.A., Hill J.A. Cardiac autophagy is a maladaptive response to hemodynamic stress. J. Clin. Invest. 2007, 117:1782-1793.
35. Zou W., Liu X., Yue P., Zhou Z., Sporn M.B., Lotan R., Khuri F.R., Sun S.Y. c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells. Cancer Res. 2004, 64:7570-7578.