Inhibiting PI3K/Akt pathway increases DNA damage of cervical carcinoma HeLa cells by drug radiosensitization

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 30, Issue 3, 2010, Pages 360-364

  Xia, Shu ^a   Yu, Shiying ^a   Fu, Qiang ^a   Liu, Fei ^a   Zheng, Wei ^a   Fu, Xiugen ^a   Zhao, Yin ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cervical carcinoma; Cisplatin; DNA damage; Docetaxel; LY294002; PI3K Akt pathway; Radiosensitization

Indexed keywords

CISPLATIN; DOCETAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RADIOSENSITIZING AGENT; TAXOID;

APOPTOSIS; ARTICLE; DNA DAMAGE; HELA CELL; HUMAN; METABOLISM; SIGNAL TRANSDUCTION;

APOPTOSIS; CISPLATIN; DNA DAMAGE; HELA CELLS; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION-SENSITIZING AGENTS; SIGNAL TRANSDUCTION; TAXOIDS;

EID: 77956367056     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-010-0357-0     Document Type: Article

References (23)

1. Jin ZH, Kurosu T, Yamaguchi M, et al. Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis. Oncogene, 2005, 24(12):1973-1981
2. Cheng JQ, Lindsley CW, Cheng GZ, et al. The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene, 2005, 24(50):7482-7492
3. Opel D, Westhoff MA, Bender A, et al. Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor-and drug-induced apoptosis. Cancer Res, 2008, 68(15):6271-6280
4. Okumura E, Fukuhara T, Yoshida H, et al. Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition. Nat Cell Biol, 2002, 4(2):111-116
5. Han R. The application of quantitative analysis of drugs'synergetic and antagonism effect. In: Zhou TC, Han R, Xu B. Chemoprevention and pharmacotherapy of tumor. Beijing: Peking Union Medical College Press, 1991:315-320
6. Tan J, Hallahan DE. Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response. Cancer Res, 2003, 63(22):7663-7667
7. Kandel ES, Skeen J, Majewski N, et al. Activation of Akt/protein kinase B overcomes a G (2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol, 2002, 22(22):7831-7841
8. Riesterer O, Tenzer A, Zingg D, et al. Novel radiosensitizers for locally advanced epithelial tumors: inhibition of the PI3K/Akt survival pathway in tumor cells and in tumor-associated endothelial cells as a novel treatment strategy? Int J Radiat Oncol Biol Phys, 2004, 58(2):361-368
9. Cordes N, van Beuningen D. Arrest of human lung fibroblasts in G2 phase after irradiation is regulated by converging phosphatidylinositol-3 kinase and beta1-integrin signaling in vitro. Int J Radiat Oncol Biol Phys, 2004, 58(2):453-462
10. Kim IA, Bae SS, Fernandes A, et al. Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer Res, 2005, 65(17):7902-7910
11. Gupta AK, Cerniglia GJ, Mick R, et al. Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002. Int J Radiat Oncol Biol Phys, 2003, 56(3):846-853
12. Lee DF, Kuo HP, Chen CT, et al. IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance. Int J Mol Med, 2008, 22(5):633-638
13. Sauer S, Bruno L, Hertweck A, et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A, 2008, 105(22):7797-7802
14. Steinberg R, Harari OA, Lidington EA, et al. A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2. J Biol Chem, 2007, 282(44):32288-32297
15. Aziz MH, Nihal M, Fu VX, et al. Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3'-kinase/Akt pathway and Bcl-2 family proteins. Mol Cancer Ther, 2006, 5(5):1335-1341
16. Clark AS, West K, Streicher S, et al. Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells. Mol Cancer Ther, 2002, 1(9):707-717
17. Canguilhem B, Pradines A, Baudouin C, et al. RhoB protects human keratinocytes from UVB-induced apoptosis through epidermal growth factor receptor signaling. J Biol Chem, 2005, 280(52):43257-43263
18. Shen Y, Mi FS. Tumor Radiation Biology. Beijing: Chinese Medicine Science Press, 2002, 52-78
19. Yin WB, Gu XZ, Xu GZ, et al. Radiation Oncology. The 4th edition. Beijing: Chinese Xiehe Medical University Press, 2008, 232-239
20. Fairbairn DW, Olive PL, O'Neill KL. The comet assay: a comprehensive review. Mutat Res, 1995, 339(1):37-59
21. Singh NP, Stephens RE. Microgel electrophoresis: sensitivity, mechanisms, and DNA electrostretching. Mutat Res, 1997, 383(2):167-175
22. Okayasu R, Takakura K, Poole S, et al. Radiosensitization of normal human cells by LY294002: Cell killing and the rejoining of DNA and interphase chromosome breaks. J Radiat Res (Tokyo), 2003, 44(4):329-333
23. Friedmann B, Caplin M, Hartley JA, et al. Modulation of DNA repair in vitro after treatment with chemotherapeutic agents by the epidermal growth factor receptor inhibitor gefitinib (ZD1839). Clin Cancer Res, 2004, 10(19):6476-6486