Autoimmune cytopaenia after paediatric intestinal transplantation: A case series

Transplant International

Volumn 23, Issue 10, 2010, Pages 1033-1037

  Botija, Gonzalo ^a   Ybarra, Marta ^a   Ramos, Esther ^a   Molina, Manuel ^a   Sarría, Jesús ^a   Martínez Ojinaga, Eva ^a   Andrés, Ane Miren ^a   López Santamaría, Manuel ^a   Prieto, Gerardo ^a  

^a HOSPITAL INFANTIL LA PAZ   (Spain)

Author keywords

autoimmune haemolytic anaemia; rituximab; sirolimus; thrombocytopaenia; transplantation

Indexed keywords

ALEFACEPT; ALEMTUZUMAB; BASILIXIMAB; IMMUNOGLOBULIN; PREDNISONE; RAPAMYCIN; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ARTICLE; AUTOIMMUNE CYTOPENIA; AUTOIMMUNE HEMOLYTIC ANEMIA; BARE LYMPHOCYTE SYNDROME; BLOOD GROUP INCOMPATIBILITY; BODY TEMPERATURE; CYTOPENIA; DRUG MEGADOSE; FEMALE; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MALE; PLASMAPHERESIS; PRIMARY HEALTH CARE; PRIORITY JOURNAL; RELAPSE; RETROSPECTIVE STUDY; SPLEEN; VIRUS INFECTION;

ANEMIA, HEMOLYTIC, AUTOIMMUNE; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEOPLASM; CHILD; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSION; INTESTINES; LYMPHOPROLIFERATIVE DISORDERS; MALE; RETROSPECTIVE STUDIES; SIROLIMUS; SPLEEN; TRANSPLANTATION, HOMOLOGOUS; VIRUS DISEASES;

EID: 77956327539     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2010.01091.x     Document Type: Article

References (25)

1. Hoffman PC. Immune hemolytic anemia-Selected topics. Hematology Am Soc Hematol Educ Program 2006 1 : 13.
2. Al-Uzri A, Yorgin PD, Kling PJ. Anemia in children after transplantation: etiology and the effect of immunosuppressive therapy on erythropoiesis. Pediatr Transplant 2003 7 : 253.
3. Schäppi MG, Ozsahin H, Peyrard T, et al. Severe autoimmune hemolytic anemia in a liver transplanted child. Pediatr Transplant 2008 12 : 809.
4. Gehrs BC, Friedberg RC. Autoimmune hemolytic anemia. Am J Hematol 2002 69 : 258.
5. Mathew P, Cheng G, Wang W. Evans syndrome: results of a national survey. J Pediatr Hematol Oncol 1997 19 : 433.
6. Peces R, Navascues RA, Laures AS, et al. Alloimmune hemolytic anemia resulting from anti A anti B antibody induced by group O graft in renal transplant recipients. Nephrol Dial Transplant 1998 13 : 1866.
7. Debska-Slizien A, Chamenia A, Krol E, et al. Hemolytic anemia after renal transplantation: analysis of case reports. Tranplant Proc 2003 35 : 2233.
8. Audet M, Panaro F, Piardi T, et al. Passenger lymphocyte syndrome and liver transplantation. Clin Dev Immunol 2008 2008 : 715769.
9. Sokol RJ, Stamps R, Booker DJ, et al. Posttransplant immune-mediated hemolysis. Transfusion 2002 42 : 198.
10. Brunner B, Kropshofer G, Ellemunter H, et al. Severe cold agglutinin disease caused by recurrent monomorphic Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD), clonally related to an EBV-negative plasmacytic hyperplasia in a pediatric multivisceral organ transplant recipient. Pediatr Transplant 2007 11 : 547.
11. Daxbock F, Zedtwitz-Liebenstein K, Burgmann H, Graninger W. Severe haemolytic anemia and excessive leukocytosis masking mycoplasma pneumonia. Ann Hematol 2001 80 : 180.
12. Mazariegos GV, Abu-Elmagd K, Jaffe R, et al. Graft versus host disease in intestinal transplantation. Am J Transplant 2004 4 : 1459.
13. Lacaille F, Moes N, Hugot JP, et al. Severe dysimmune cytopenia in children treated with tacrolimus after organ transplantation. Am J Transplant 2006 6 : 1072.
14. Trimarchi HM, Truong MD, Brennan S, et al. FK506-associated thrombotic microangiopathy: report of two cases and review of the literature. Transplantation 1999 67 : 539.
15. Schmidt RH, Lenz T, Grone HJ, et al. Hemolytic-uraemic syndrome after tacrolimus rescue therapy for cortisone-resistant rejection. Nephrol Dial Transplant 1999 14 : 979.
16. Kato T, Tzakis AG, Selvaggi G, et al. Transplantation of the spleen. Effect of splenic allograft in human multivisceral transplantation. Ann Surg 2007 246 : 436.
17. Lawrence D, Petz MD. Treatment of autoimmune hemolytic anemias. Curr Opin Hematol 2001 8 : 411.
18. Garvey B. Rituximab in the treatment of haematological disorders. Br J Haematol 2008 141 : 149.
19. Zecca M, Nobili B, Ramengui U, et al. Rituximab for the treatment of refractory autoimmune hemolytic anemia in children. Blood 2003 101 : 3857.
20. Quartier P, Brenthon B, Philippet P, et al. Treatment of childhood autoimmune haemolytic anaemia with rituximab. Lancet 2001 358 : 1511.
21. Rao A, Kelly M, Musselman M, et al. Safety, efficacy and immune reconstitution after rituximab therapy in pediatric patients with chronic or refractory hematologic autoimmune cytopenias. Pediatr Blood Cancer 2008 50 : 822.
22. Willis F, Marsh JC, Bevan DH, et al. The effect of treatment with Campath-1H in patients with autoimmune cytopenias. Br J Haematol 2001 114 : 891.
23. Cheung WW, Hwang GY, Tse E, Kwong YL. Alemtuzumab induces complete remission of autoimmune haemolytic anemia refractory to corticosteroids, splenectomy and rituximab. Haematologica 2006 91 : 13.
24. Al-Hussaini A, Tredger JM, Dhawan A. Immunosuppression in pediatric liver and intestinal transplantation: a closer look at the arsenal. J Pediatr Gastroenterol Nutr 2005 41 : 152.
25. Valentini RP, Imam A, Warrier Y, et al. Sirolimus rescue for tacrolimus-associated post-transplant autoimmune hemolytic anemia. Pediatr Transplant 2006 10 : 358.