Severe cold agglutinin disease caused by recurrent monomorphic Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD), clonally related to an EBV-negative plasmacytic hyperplasia in a pediatric multivisceral organ transplant recipient

Pediatric Transplantation

Volumn 11, Issue 5, 2007, Pages 547-551

  Brunner, Barbara ^a   Kropshofer, Gabriele ^a   Ellemunter, Helmut ^a   Brunner, Andrea ^b   Mueller, Thomas ^a   Margreiter, Raimund ^a   Tzankov, Alexandar ^c  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b MEDICAL UNIVERSITY OF INNSBRUCK   (Austria)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Cold agglutinin disease; Pediatric multivisceral organ transplantation; Post transplant lymphoproliferative disorder

Indexed keywords

AZATHIOPRINE; COLD AGGLUTININ; CYCLOPHOSPHAMIDE; GANCICLOVIR; HEPARIN; HETASTARCH; IMMUNOGLOBULIN HEAVY CHAIN; INTERLEUKIN 2 RECEPTOR ANTIBODY; METHYLPREDNISOLONE; PREDNISOLONE; RITUXIMAB; STEROID; TACROLIMUS;

ACUTE GRAFT REJECTION; ARTICLE; AUTOIMMUNE HEMOLYTIC ANEMIA; B CELL LYMPHOMA; CASE REPORT; CELL MIGRATION; COLD AGGLUTININ SYNDROME; COOMBS TEST; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; DRUG DOSE REDUCTION; EPSTEIN BARR VIRUS; FEMALE; FEMORAL VEIN; GRAFT RECIPIENT; HEMOLYTIC ANEMIA; HIRSCHSPRUNG DISEASE; HUMAN; ILIAC VEIN; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOTHERAPY; INTESTINE RESECTION; LEG AMPUTATION; LIVER CIRRHOSIS; LYMPHATIC SYSTEM DISEASE; LYMPHOPROLIFERATIVE DISEASE; MULTIPLE CYCLE TREATMENT; ORGAN TRANSPLANTATION; PARENTERAL NUTRITION; PLASMACYTIC HYPERPLASIA; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; PRESCHOOL CHILD; RECURRENT DISEASE; REMISSION; SINGLE DRUG DOSE; VEIN THROMBOSIS;

ANEMIA, HEMOLYTIC, AUTOIMMUNE; ANTIBODIES, VIRAL; BIOPSY; BONE MARROW; DUODENUM; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; FOLLOW-UP STUDIES; HERPESVIRUS 4, HUMAN; HUMANS; HYPERPLASIA; INFANT; INTESTINE, SMALL; LIVER TRANSPLANTATION; LYMPHOPROLIFERATIVE DISORDERS; ORGAN TRANSPLANTATION; PANCREAS TRANSPLANTATION; PLASMA CELLS; RECURRENCE; STOMACH;

EID: 34447343844     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2007.00711.x     Document Type: Article

References (17)

1. Harris NL, Swerdlow SH, Frizzera G, Knowles DM. Post-transplant lymphoproliferative disorders. In : Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. Tumours of Haematopoietic and Lymphoid Tissues. Lyon : IARC Press, 2001 : pp. 264 269.
2. Nalesnik MA, Demetris AJ, Fung JJ, Randhawa P, Zeevi A. http://www.medscape.com/viewprogram/324 accessed 15 December, 2000.
3. Leblond V, Davi F, Charlotte F, et al. Posttransplant lymphoproliferative disorders not associated with Epstein-Barr virus: A distinct entity? J Clin Oncol 1998 : 16 : 2052 2059.
4. Allen UD, Farkas G, Hebert D, et al. Risk factors for post-transplantation lymphoproliferative disorder in pediatric patients: A case-control study. Pediatr Transplant 2005 : 9 : 450 455.
5. Young LS, Dawson CW, Eliopoulos AG. The expression and function of Epstein-Barr virus encoded latent genes. Mol Pathol 2000 : 53 : 238 247.
6. Smets F, Sokal EM. Epstein-Barr virus-related lymphoproliferation in children after liver transplant: Role of immunity, diagnosis and management. Pediatr Transplant 2002 : 6 : 280 287.
7. Nalesnik MA. The diverse pathology of post-transplant lymphoproliferative disorders: The importance of a standardized approach. Transplant Infect Dis 2001 : 3 : 88 96.
8. Green M, Michaels MG, Webber SA, Rowe D, Reyes J. The management of Epstein-Barr virus associated post-transplant lymphoproliferative disorders in pediatric solid organ transplant recipients. Pediatr Transplant 1999 : 3 : 271 281.
9. Buell JF, Gross TG, Hanaway MJ, et al. Chemotherapy for posttransplant lymphoproliferative disorder: The Israel Penn International Transplant Tumor Registry experience. Transplant Proc 2005 : 37 : 956 957.
10. Gross TG, Bucuvalas JC, Park JR, et al. Low-dose chemotherapy for Epstein-Barr Virus-positive post-transplantation lymphoproliferative disease in children after solid organ transplantation. J Clin Oncol 2005 : 23 : 6481 6488.
11. Orjuela M, Gross TG, Cheung Y-K, Alobeid B, Morris E, Cairo MS. A pilot study of chemoimmunotherapy (cyclophosphamide, prednisone, and rituximab) in patients with post-transplant lymphoproliferative disorder following solid organ transplantation. Clin Cancer Res 2003 : 9 (Suppl. 3945 3952.
12. Aberle SW, Puchhammer-Stöckl E. Diagnosis of herpesvirus infections of the central nervous system. J Clin Virol 2002 : 25 : 79 85.
13. Fong D, Kaiser A, Spizzo G, Gastl G, Tzankov A. Hodgkin's disease variant of Richter's syndrome in chronic lymphoctic leukemia patients previously treated with fludarabine. Br J Haematol 2005 : 129 : 199 205.
14. Sevilla J, Del Carmen Escudero M, Jimenez R, et al. Severe systemic autoimmune disease associated with Epstein-Barr virus infection. J Pediatr Hematol Oncol 2004 : 26 : 831 833.
15. Berentsen S, Ulvestad E, Gjertsen BT, et al. Rituximab for primary chronic cold agglutinin disease: A prospective study of 37 courses of therapy in 27 patients. Blood 2004 : 103 : 2925 2928.
16. Kitamura T, Mizuta K, Kawarasaki H, Sugawara Y, Makuuchi M. Severe hemolytic anemia related to production of cold agglutinins following living donor liver transplantation: A case report. Transplant Proc 2003 : 35 : 399 400.
17. Axelrod DA, Holmes R, Thomas SE, Magee JC. Limitations of EBV-PCR monitoring to detect EBV associated post-transplant lymphoproliferative disorder. Pediatr Transplant 2003 : 7 : 223 227.