Severe dysimmune cytopenia in children treated with tacrolimus after organ transplantation

American Journal of Transplantation

Volumn 6, Issue 5 I, 2006, Pages 1072-1076

  Lacaille, F ^a   Moes, N ^b   Hugot, J P ^c   Cezard, J P ^c   Goulet, O ^a,b   Ruemmele, F M ^a,b  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^c HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

Autoimmune anemia; Autoimmune thrombo cytopenia; Dysimmunity; Tacrolimus

Indexed keywords

CD20 ANTIBODY; CORTICOSTEROID; CYCLOSPORIN; METHYLPREDNISOLONE; MONOCLONAL ANTIBODY; PREDNISONE; RITUXIMAB; STEROID; TACROLIMUS; THROMBOCYTE ANTIBODY;

ANEMIA; ANGIONEUROTIC EDEMA; ARTICLE; CHILD; CLINICAL ARTICLE; COOMBS POSITIVE HEMOLYTIC ANEMIA; COOMBS TEST; CYTOPENIA; DIARRHEA; DOSE RESPONSE; FEMALE; FOOD ALLERGY; GRAFT REJECTION; HUMAN; HUMAN TISSUE; HYPERSPLENISM; INTESTINE TRANSPLANTATION; LIVER TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; MALE; MUCOSAL BLEEDING; PRIORITY JOURNAL; SEPTICEMIA; THROMBOCYTOPENIA; CASE REPORT; CHEMICALLY INDUCED DISORDER; HEMATOLOGIC DISEASE; HISTOCOMPATIBILITY;

ANEMIA; CHILD; FEMALE; HEMATOLOGIC DISEASES; HUMANS; MALE; TACROLIMUS; TRANSPLANTATION IMMUNOLOGY;

EID: 33745227368     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2006.01304.x     Document Type: Article

References (24)

1. Jain A, Mazariegos G, Kashyap R et al. Comparative long-term evaluation of tacrolimus and cyclosporine in pediatric liver transplantation. Transplantation 2000; 70: 617-625.
2. Grant D. Current results of intestinal transplantation. The International Intestinal Transplant Registry. Lancet 1996; 347: 1801-1803.
3. Ho S, Clipstone N, Timmermann L et al. The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol 1996; 80: S40-S45.
4. Siemann G, Blume R, Grapentin D, Oetjen E, Schwaninger M, Knepel W. Inhibition of cyclic AMP response element-binding protein/cyclic AMP response element-mediated transcription by the immunosuppressive drugs cyclosporin A and FK506 depends on the promoter context. Mol Pharmacol 1999; 55: 1094-1100.
5. Mouzaki A, Rungger D. Properties of transcription factors regulating interleukin-2 gene transcription through the NFAT binding site in untreated or drug-treated naive and memory T-helper cells. Blood 1994; 84: 2612-2621.
6. Sawada S, Suzuki G, Kawase Y, Takaku F. Novel immuosuppressive agent, FK506. In vitro effects on the cloned T cell activation. J Immunol 1987; 139: 1797-1803.
7. Flesland O, Solheim BG, Mellbye OJ, Albrechtsen DA. Occurrence of autoantibodies after solid-organ transplantation. Transplantation 1991; 52: 921-923.
8. Kerkar N, Hadzic N, Davies ET et al. De novo autoimmune hepatitis after liver transplantation. Lancet 1998; 351: 409-413.
9. Quartier P, Brethon B, Philippet P, Landman-Parker J, Le Deist F, Fischer A. Treatment of childhood autoimmune haemolytic anaemia with rituximab. Lancet 2001; 358: 1511-1513.
10. Sevilla J, del Carmen Escudero M, Jimenez R et al. Severe systemic autoimmune disease associated with Epstein-Barr virus infection. J Pediatr Hematol Oncol 2004; 26: 831-833.
11. Prassouli A, Papadakis V, Tsakris A et al. Classic transient erythroblastopenia of childhood with human parvovirus B19 genome detection in the blood and bone marrow. J Pediatr Hematol Oncol 2005; 27: 333-336.
12. Daxbock F, Zedtwitz-Liebenstein K, Burgmann H, Graninger W. Severe hemolytic anemia and excessive leukocytosis masking mycoplasma pneumonia. Ann Hematol 2001; 80: 180-182.
13. Petz LD. Immune hemolysis associated with transplantation. Semin Hematol 2005; 42: 145-155.
14. Steinmann L. Escape from "Horror toxicus": Pathogenesis and treatment of autoimmune disease. Cell 1995; 80: 7-10.
15. Frohn C, Jabs WJ, Fricke L, Goerg S. Hemolytic anemia after kidney transplantation: Case report and differential diagnosis. Ann Hematol 2002; 81: 158-160.
16. Cartron J, Blesson S, Celton JL, Bertheleme JP, Broyer M, Niaudet P. Hemolytic anemia after kidney transplantation. Presse Med 1994; 23: 707-709.
17. West KA, Anderson DR, McAlister VC et al. Alloimmune thrombocytopenia after organ transplantation. N Engl J Med 1999; 341: 1504-1507.
18. Beschorner WE, Suresch DL, Shinozawa T, Santos GW, Hess AD. Thymic immunopathology after cyclosporine: Effect of irradiation and age on medullary involution and recovery. Transplant Proc 1988; 20: 1072-1078.
19. Czaja AJ. Autoimmune hepatitis after liver transplantation and other lessons of self-intolerance. Liver Transpl 2002; 8: 505-513.
20. Lotem J, Kama R, Sachs L. Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin. Proc Natl Acad Sci USA 1999; 96: 12016-12020.
21. Wang HG, Pathan N, Ethell IM et al. Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 1999; 284: 339-343.
22. Christianson SW, Shultz LD, Leiter EH. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors. Diabetes 1993; 42: 44-55.
23. Serreze DV, Chapman HD, Varnum DS et al. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice. J Exp Med 1996; 184: 2049-2053.
24. Petz LD. Treatment of autoimmune hemolytic anemia. Curr Opin Hematol 2001; 8: 411-416.