Severe autoimmune hemolytic anemia in a liver transplanted child

Pediatric Transplantation

Volumn 12, Issue 7, 2008, Pages 809-812

  Schäppi, Michela G ^a,b   Ozsahin, Hulya ^b   Peyrard, Thierry ^c   Gumy Pause, Fabienne ^b   Posfay Barbe, Klara M ^b   Chardot, Christophe ^b   Belli, Dominique C ^b   Siegenthaler, Michèle A ^b  

^a Hopital des Enfants Hopitaux universitaires de Geneve   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^c INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE   (France)

Author keywords

Child; Hemolytic anemia; Liver transplantation; Rituximab; Warm acting cold agglutinin

Indexed keywords

COTRIMOXAZOLE; CYCLOSPORIN A; FLUCONAZOLE; GANCICLOVIR; HYPERIMMUNE GLOBULIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; METHYLPREDNISOLONE; PIPERACILLIN PLUS TAZOBACTAM; RITUXIMAB; TACROLIMUS; VALACICLOVIR;

AGRANULOCYTOSIS; ANTIMICROBIAL THERAPY; ARTICLE; AUTOIMMUNE HEMOLYTIC ANEMIA; BLOOD TRANSFUSION; CASE REPORT; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG MEGADOSE; DRUG SUBSTITUTION; HUMAN; INFECTION; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MALE; PRESCHOOL CHILD; TREATMENT INDICATION;

ANEMIA, HEMOLYTIC, AUTOIMMUNE; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; BLOOD TRANSFUSION; CHILD; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOLOGIC FACTORS; INFANT; LIVER DISEASES; LIVER TRANSPLANTATION; MALE;

EID: 53849141171     PISSN: 13973142     EISSN: 13993046     Source Type: Journal    
DOI: 10.1111/j.1399-3046.2008.00934.x     Document Type: Article

References (30)

1. Kitamura T, Mizuta K, Kawarasaki H, Sugawara Y, Makuuchi M. Severe hemolytic anemia related to production of cold agglutinins following living donor liver transplantation: A case report. Transplant Proc 2003 : 35 : 399 400.
2. Nguyen CWW, Merker J, Berquist W, Fontaine M, Glader B. Autoimmune hemolytic anemia in pediatric liver transplant patients on FK506. Transplantation 2006 : 82 : 987.
3. Petz LD, Garratty G. Immune Hemolytic Anemias, 2nd edn. Philadelphia, PA : Churchill Livingston, 2004.
4. Mccann EL, Shirey R, Kickler T, Ness P. IgM autoagglutinins in warm autoimmune hemolytic anemia: A poor prognostic feature. Acta Haematol 1992 : 88 : 120 125.
5. Shulman IA, Branch DR, Nelson JM, Thompson JC, Saxena S, Petz LD. Autoimmune hemolytic anemia with both cold and warm autoantibodies. JAMA 1985 : 253 : 1746 1748.
6. Maheshwari A, Mishra R, Thuluvath PJ. Post-liver-transplant anemia: Etiology and management. Liver Transpl 2004 : 10 : 165 173.
7. Danesi R, Del Tacca M. Hematologic toxicity of immunosuppressive treatment. Transplant Proc 2004 : 36 : 703 704.
8. Schäppi MG, Belli DC, Rimensberger PC, et al. Fatal GvHD as a complication of liver transplantation for undetermined fulminant hepatic failure and associated aplastic anemia. Liver Transpl 2006 : 12 : 1693 1697.
9. Digiuseppe JA, Bastacky SI, Shirey RS, Silberman MA, Hutchins GM, Ness PM. Tacrolimus-related posttransplant lymphoproliferative disorder presenting as autoimmune hemolytic anemia. Arch Pathol Lab Med 1996 : 120 : 282 285.
10. Johnson ST, Fueger JT, Gottschall JL. One center's experience: The serology and drugs associated with drug-induced immune hemolytic anemia-a new paradigm. Transfusion 2007 : 47 : 697 702.
11. Skogsberg U, Breimer ME, Friman S, et al. Adult ABO-incompatible liver transplantation, using A and B donors. Xenotransplantation 2006 : 13 : 154 159.
12. Sokol RJ, Stamps R, Booker DJ, et al. Posttransplant immune-mediated hemolysis. Transfusion 2002 : 42 : 198 204.
13. Retana AK, Kaplan MM, Erban JK. Autoimmune hemolytic anemia in patients with liver transplants for primary biliary cirrhosis: Three case reports and a review of the literature. Am J Gastroenterol 2006 : 101 : 1 4.
14. Brunner B, Kropshofer G, Ellemunter H, et al. Severe cold agglutinin disease caused by recurrent monomorphic Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD), clonally related to an EBV-negative plasmacytic hyperplasia in a pediatric multivisceral organ transplant recipient. Pediatr Transplant 2007 : 11 : 547 551.
15. Sachs UJ, Roder L, Santoso S, Bein G. Does a negative direct antiglobulin test exclude warm autoimmune haemolytic anaemia? A prospective study of 504 cases. Br J Haematol 2006 : 132 : 655 656.
16. Friedmann A, King K, Shirey R, Resar L, Casella J. Fatal autoimmune hemolytic anemia in a child due to warm-reactive immunoglobulin M antibody. J Pediatr Hematol Oncol 1998 : 20 : 502 505.
17. Freedman J, Wright J, Lim FC, Garvey MB. Hemolytic warm IgM autoagglutinins in autoimmune hemolytic anemia. Transfusion 1987 : 27 : 464 467.
18. Shirey RS, Kickler TS, Bell W, Little B, Smith B, Ness PM. Fatal immune hemolytic anemia and hepatic failure associated with a warm-reacting IgM autoantibody. Vox Sang 1987 : 52 : 219 222.
19. Nowak-Wegrzyn A, King KE, Shirey RS, Chen AR, Mcdonough C, Lederman HM. Fatal warm autoimmune hemolytic anemia resulting from IgM autoagglutinins in an infant with severe combined immunodeficiency. J Pediatr Hematol Oncol 2001 : 23 : 250 252.
20. Garratty G, Arndt P, Domen R, et al. Severe autoimmune hemolytic anemia associated with IgM warm autoantibodies directed against determinants on or associated with glycophorin A. Vox Sang 1997 : 72 : 124 130.
21. Salama A, Mueller-Eckhardt C. Autoimmune haemolytic anaemia in childhood associated with non-complement binding IgM autoantibodies. Br J Haematol 1987 : 65 : 67 71.
22. Jubinsky PT, Rashid N. Successful treatment of a patient with mixed warm and cold antibody mediated Evans syndrome and glucose intolerance. Pediatr Blood Cancer 2005 : 45 : 347 350.
23. Sevilla J, Del Carmen Escudero M, Jimenez R, et al. Severe systemic autoimmune disease associated with Epstein-Barr virus infection. J Pediatr Hematol Oncol 2004 : 26 : 831 833.
24. Kutti J, Wadenvik H, Safai-Kutti S, et al. Successful treatment of refractory autoimmune haemolytic anaemia by plasmapheresis. Scand J Haematol 1984 : 32 : 149 152.
25. D'Arena G, Califano C, Annunziata M, et al. Rituximab for warm-type idiopathic autoimmune hemolytic anemia: A retrospective study of 11 adult patients. Eur J Haematol 2007 : 79 : 53 58.
26. King K, Ness P. Treatment of autoimmune hemolytic anemia. Sem Hematol 2005 : 42 : 131 136.
27. Zecca M, DE Stefano P, Nobili B, Locatelli F. Anti-CD20 monoclonal antibody for the treatment of severe, immune-mediated, pure red cell aplasia and hemolytic anemia. Blood 2001 : 97 : 3995 3997.
28. Quartier P, Brethon B, Philippet P, Landman-Parker J, Le Deist F, Fischer A. Treatment of childhood autoimmune haemolytic anaemia with rituximab. Lancet 2001 : 358 : 1511 1513.
29. Giulino LB, Bussel JB, Neufeld EJ. Treatment with rituximab in benign and malignant hematologic disorders in children. J Pediatr 2007 : 150 : 338 344.
30. Yaddanapudi R. Treatment of refractory immune cytopenias in the 21st century-how safe is rituximab? Am J Hematol 2005 : 80 : 92 93.