Proteolysis of Pseudomonas exotoxin A within hepatic endosomes by cathepsins B and D produces fragments displaying in vitro ADP-ribosylating and apoptotic effects

FEBS Journal

Volumn 277, Issue 18, 2010, Pages 3735-3749

  El Hage, Tatiana ^a,b   Lorin, Séverine ^b   Decottignies, Paulette ^b,c   Djavaheri Mergny, Mojgan ^d   Authier, François ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c CNRS   (France)

^d INSTITUT BERGONIÉ   (France)

Author keywords

cathepsin; endocytosis; endosome; Pseudomonas exotoxin A; translocation

Indexed keywords

CASPASE 3; CASPASE 9; CATHEPSIN B; CATHEPSIN D; CYTOCHROME C; PSEUDOMONAS EXOTOXIN; PSEUDOMONAS EXOTOXIN A; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CYTOTOXICITY; ENDOCYTOSIS; ENDOSOME; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PSEUDOMONAS; RAT;

PSEUDOMONAS EXOTOXIN; RATTUS; RODENTIA;

EID: 77956322010     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07775.x     Document Type: Article

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