Synthesis, in vitro activity, and three-dimensional quantitative Structure-activity relationship of novel hydrazine inhibitors of human vascular adhesion protein-1

Journal of Medicinal Chemistry

Volumn 53, Issue 17, 2010, Pages 6301-6315

  Nurminen, Elisa M ^a   Pihlavisto, Marjo ^b   Lázár, László ^c   Szakonyi, Zsolt ^c   Pentikäinen, Ulla ^a   Fülöp, Ferenc ^c   Pentikäinen, Olli T ^a  

^a UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^b Biotie Therapies Corp   (Finland)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

(1 METHYLHYDRAZINO) 1 (2 NAPHTHYL)ETHANOL; 1 (2 CHLOROPHENYL) 2 (1 METHYLHYDRAZINO)ETHANOL; 1 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 2 (1 METHYLHYDRAZINO) ETHANOL; 1 (3 METHOXYPHENYL) 2 (1 METHYLHYDRAZINO)ETHANOL; 1 (4 CHLOROPHENYL) 2 (1 METHYLHYDRAZINO)ETHANOL; 1 (4 FLUOROPHENYL) 2 (1 METHYLHYDRAZINO)ETHANOL; 1 (4 METHOXYPHENYL) 2 (1 METHYLHYDRAZINO)ETHANOL; 1 [2 (2 CHLOROPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 [2 (2 FLUOROPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 [2 (2 METHOXYPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 [2 (2,3,4 TRIMETHOXYPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 [2 (2,5 DIMETHOXYPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 [2 (3 CHLOROPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 [2 (3 METHOXYPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 [2 (3,4 DIMETHOXYPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 [2 (3,4,5 TRIMETHOXYPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 [2 (4 CHLOROPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 [2 (4 FLUOROPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 [2 (4 METHOXYPHENYL)ETHYL] 1 METHYLHYDRAZINE; 1 ETHYL 1 (2 PHENYLETHYL)HYDRAZINE; 1 ETHYL 1 [2 (3,4,5 TRIMETHOXYPHENYL)ETHYL]HYDRAZINE; 1 ETHYL 1 [2 (4 METHOXYPHENYL)ETHYL]HYDRAZINE; 1 ISOBUTYL 1 (2 PHENYLETHYL)HYDRAZINE; 1 ISOBUTYL 1 [2 (4 METHOXYPHENYL)ETHYL]HYDRAZINE; 1 METHYL 1 (2 PHENYLETHYL)HYDRAZINE; 1 METHYL 1 (3 PHENYLPROPYL)HYDRAZINE; 2 (1 METHYLHYDRAZINO) 1 PHENYLETHANOL; 2 (1' METHYLHYDRAZINO) 1 (2,3,4 TRIMETHOXYPHENYL)ETHANOL; HYDRAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; LIGAND BINDING; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

AMINE OXIDASE (COPPER-CONTAINING); ANIMALS; BINDING SITES; CELL ADHESION MOLECULES; CRICETINAE; CRICETULUS; HUMANS; HYDRAZINES; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; MONOAMINE OXIDASE; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; STEREOISOMERISM;

EID: 77956316925     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100337z     Document Type: Article

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