Neurological soft signs in individuals with schizotypal personality features

Australian and New Zealand Journal of Psychiatry

Volumn 44, Issue 9, 2010, Pages 800-804

  Chan, Raymond C K ^a   Wang, Ya ^a   Zhao, Qing ^a,b   Yan, Chao ^a,b   Xu, Ting ^a,b   Gong, Qi Yong ^c   Manschreck, Theo C ^d  

^a INSTITUTE OF PSYCHOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c SICHUAN UNIVERSITY   (China)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Neurological soft signs; Schizophrenia spectrum disorders; Schizotypy

Indexed keywords

ADULT; ARTICLE; CHINA; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR COORDINATION; NEUROLOGIC DISEASE; PSYCHOMETRY; QUESTIONNAIRE; SCHIZOPHRENIA; SCHIZOTYPAL PERSONALITY DISORDER; SCHIZOTYPAL PERSONALITY QUESTIONNAIRE; SENSORY EVALUATION;

ANALYSIS OF VARIANCE; ENDOPHENOTYPES; FEMALE; HUMANS; MALE; NEUROLOGIC EXAMINATION; PERSONALITY INVENTORY; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMETRICS; QUESTIONNAIRES; SCHIZOTYPAL PERSONALITY DISORDER; YOUNG ADULT;

EID: 77956316576     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.3109/00048674.2010.482920     Document Type: Article

References (36)

1. Braff DL, Freedman R, Schork NJ, Gottesman II. Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull 2007; 33:21-32.
2. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160:636-645.
3. Chan RCK, Gottesman II. Neurological soft signs as candidate endophenotypes for schizophrenia: a shooting star or a northern star? Neurosci Biobehav Rev 2008; 32:957-971.
4. Egan MF, Hyde TM, Bonomo JB, Mattay VS, Bigelow LB, Goldberg TE, Weinberger DR. Relative risk of neurological signs in siblings of patients with schizophrenia. Am J Psychiatry 2001; 1827-1834.
5. Meyer-Lindenberg A, Weinberger DR. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews Neuroscience 2006; 7:818-827.
6. Heinrichs DW, Buchanan RW. Significance and meaning of neurological signs in schizophrenia. Am J Psychiatry 1988; 145:11-18.
7. Chen EYH, Shapleske J, Luque R, McKenna PJ, Hodges JR, Callloway SP, Hymas NFS, Dening TR, Berrios GE. The Cambridge Neurological Inventory: a clinical instrument for soft neurological signs and the further neurological examination for psychiatric patients. Psychiatry Res 1995; 56:183-202.
8. Simpson GM, Angus JWS. Drug induced extrapyramidal disorders. Acta Psychiatr Scand 1970; 212:1-58.
9. Chan RCK, Rao HY, Chen EYH, Ye BB, Zhang C. The neural basis of motor coordination soft signs: an fMRI study of healthy subjects. Neurosci Lett 2006; 398:189-194.
10. Rao H, Di X, Chan RCK, Ding Y, Ye B, Gao D. A regulation role of the prefrontal cortex in the fist-edge-palm task: evidence from functional connectivity analysis. Neuroimage 2008; 41: 1345-1351.
11. Weinberger DR, Wyatt RJ. Cerebral ventricular size: a biological marker for subtyping schizophrenia. In: Usdin F and Hanin I, eds. Biological markers in psychiatry and neurology. Oxford: Pergamon Press, 1982:505-512.
12. Chan RCK, Di X, McAlonan GM, Gong Q. Brain anatomical abnormalities in high risk individuals, first-episode and chronic schizophrenia: an activation likelihood estimation meta-analysis of illness progress. Schizophr Bull in press, doi:10.1093/schbul/sbp073.
13. Chan RCK, Xu T, Heinrichs RW, Yu Y, Wang Y. Neurological soft signs in schizophrenia: a meta analysis. Schizophr Bull in press, doi:10.1093/schbul/ sbp011.
14. Chan RCK, Xu T, Heinrichs RW, Yu Y, Gong Q. Neurological soft signs in non-psychotic first-degree relatves of patients with schizophrenia: a systematic review and meta-analysis. Neurosci Biobehav Rev 2010; 34:889-896.
15. Cornblatt BA, Malhotra AK. Impaired attention as an endophenotype for molecular genetic studies of schizophrenia. American Journal of Medical Genetics (Neuropsychiatry Genetics) 2001; 105:11-15.
16. Chen WJ, Faraone SV. Sustained attention deficits as markers of genetic susceptibility to schizophrenia. Am J Med Genet 2000; 97:52-57.
17. Gourion D, Goldberger CL, Bourdel MC, Bayle FJ, Millet B, Olie JP, Krebs MO. Neurological soft-signs and minor physical anomalies in schizophrenia: differential transmission within families. Schizophr Res 2003; 63:181-187.
18. Gourion D, Goldberger C, Olie J, Loo H, Krebs M. Neurological and morphological anomalies and the genetic liability to schizophrenia: a composite phenotype. Schizophr Res 2004; 67:23-31.
19. Mechri A, Bourdel MC, Slama H, Gourion D, Gaha L, Krebs MO. Neurological soft signs in patients with schizophrenia and their unaffected siblings: frequency and correlates in two ethnic and socioeconomic distinct populations. Eur Arch Psychiatry Clin Neurosci 2009; 259:218-226.
20. Raine A. Schizotypal personality: neurodevelopmental and psychosocial trajectories. Ann Rev Clin Psychol 2006; 2:291-326.
21. Chan RCK, Chen EYH. Neurological abnormalities in Chinese patients with schizophrenia. Behavioural Neurology 2007; 18: 171-181.
22. Raine A. The SPQ: a scale for the assessment of schizotypal personality based on DSM-III-R criteria. Schizophr Bull 1991; 17:555-564.
23. Chen WJ, Hsiao CK, Lin CCH. Schizotypy in community samples: the three-factor structure and correlation with sustained attention. J Abnorm Psychol 1997; 106:649-654.
24. Raine A, Reynolds C, Lencz T, Scerbo A, Triphon N, Kim D. Cognitive-perceptual, interpersonal, and disorganized features of schizotypal personality. Schizophr Bull 1994; 20:191-201.
25. Gong YX. Manual of Wechsler Adult Intelligence Scale: Chinese version. Changsha: Chinese Map Press, 1992.
26. Spreen O, Strauss E. A compendium of neuropsychological tests: administration, norms, and commentary. New York: Oxford University Press, 1991.
27. Barkus E, Stirling J, Hopkins R, Lewis S. The presence of neurological soft signs along the psychosis proneness continuum. Schizophr Bull 2006; 32:573-577.
28. Bollini AM, Compton MT, Esterberg ML, Rutland J, Chien VH, Walker EF. Associations between schizotypal features and indicators of neurological and morphological abnormalities. Schizophr Res 2007; 92:32-40.
29. Barrantes-Vidal N, Fananas L, Rosa A, Caparros B, Riba MD, Obiols JE. Neurocognitive, behavioural and neurodevelopmental correlates of schizotypy clusters in adolescents from the general population. Schizophr Res 2002; 61:293-302.
30. Cannon TD, Huttunen MO, Lonnqvist J, Tuulio-Henriksson A, Pirkola T, Glahn D, Finkelstein J, Hietanen M, Kapriol J, Kosken-vuno M. Inheritance of neuropsychological functions in twins discordant for schizophrenia. Am J Hum Genet 2000; 67:369-382.
31. Cannon TD, Gasperoni TL, van Erp TGM, Rosso IM. Quantitative neural indicators of liability to schizophrenia: implications for molecular genetic studies. Am J Med Genet 2001; 105:16-19.
32. Wang Q, Chan RCK, Sun J, Yao J, Deng W, Sun X, Liu X, Sham PC, Ma X, Meng H, Murray RM, Collier DC, Li T. Reaction time of continuous performance test is an endophenotypic marker for schizophrenia: a study of first-episode drug-naive schizophrenia, nonpsychotic first-degree relatives and healthy controls. Schizophr Res 2007; 89:293-298.
33. Park S, Holzman PS, Goldman-Rakic PS. Spatial working memory deficits in the relatives of schizophrenic patients. Arch Gen Psychiatry 1995; 52:821-828.
34. Goldberg TE, Torrey EF, Gold JM. Genetic risk of neuropsycho-logical impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder. Schizophr Res 1995; 17:77-84.
35. Cadenhead KS, Braff DL. Endophenotyping schizotypy: a prelude to genetic studies within the schizophrenia spectrum. Schizophr Res 2002; 54:47-57.
36. Bedwell JS, Kamath V, Baksh E. Comparison of three computer-administered cognitive tasks as putative endophenotypes of schizophrenia. Schizophr Res 2006; 88:36-46.