Interleukin 18 receptor 1 expression distinguishes patients with multiple sclerosis

Multiple Sclerosis

Volumn 16, Issue 9, 2010, Pages 1056-1065

  Gillett, Alan ^a   Hedreul, Melanie Thessen ^a   Khademi, Mohsen ^a   Espinosa, Alexander ^b   Beyeen, Amennai D ^a   Jagodic, Maja ^a   Kockum, Ingrid ^a   Harris, Robert A ^a   Olsson, Tomas ^a  

^a Department of Clinical Neuroscience   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

association study; gene expression; immune complex disease; interleukin 18 receptor 1; interleukin 18; TH1 cells

Indexed keywords

INTERLEUKIN 18 RECEPTOR ALPHA; MESSENGER RNA;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; GENOME; HUMAN; HUMAN CELL; IL18R1 GENE; IMMUNOREGULATION; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; SWEDEN; UP-REGULATION; YOUNG ADULT;

EID: 77956307587     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458510364634     Document Type: Article

References (43)

1. Compston A., Coles A. Multiple sclerosis. Lancet 2008 ; 372: 1502-1517.
2. Hafler DA, Compston A., Sawcer S., et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007 ; 357: 851-862.
3. Lundmark F., Duvefelt K., Iacobaeus E., et al. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet 2007 ; 39: 1108-1113.
4. Gregory SG, Schmidt S., Seth P., et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 2007 ; 39: 1083-1091.
5. Hoppenbrouwers IA, Aulchenko YS, Ebers GC, et al. EVI5 is a risk gene for multiple sclerosis. Genes Immun 2008 ; 9: 334-337.
6. Rubio JP, Stankovich J., Field J., et al. Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians. Genes Immun 2008 ; 9: 624-630.
7. Brynedal B., Bomfim IL, Olsson T., Duvefelt K., Hillert J. Differential expression, and genetic association, of CD58 in Swedish multiple sclerosis patients. Proc Natl Acad Sci U S A 2009 ; 106: E58 ; author reply E59.
8. Hafler JP, Maier LM, Cooper JD, et al. CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun 2009 ; 10: 5-10.
9. De Jager PL, Jia X., Wang J., et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 2009 ; 41: 776-782.
10. Bielekova B., Martin R. Development of biomarkers in multiple sclerosis. Brain 2004 ; 127: 1463-1478.
11. Gutcher I., Urich E., Wolter K., Prinz M., Becher B. Interleukin 18-independent engagement of interleukin 18 receptor-alpha is required for autoimmune inflammation. Nat Immunol 2006 ; 7: 946-953.
12. Thessen Hedreul M., Gillett A., Olsson T., Jagodic M., Harris RA Characterization of multiple sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis. J Neuroimmunol 2009 ; 21: 30-39.
13. Arend WP, Palmer G., Gabay C. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev 2008 ; 223: 20-38.
14. Okamura H., Tsutsi H., Komatsu T., et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995 ; 378: 88-91.
15. Nicoletti F., Di Marco R., Mangano K., et al. Increased serum levels of interleukin-18 in patients with multiple sclerosis. Neurology 2001 ; 57: 342-344.
16. Losy J., Niezgoda A. IL-18 in patients with multiple sclerosis. Acta Neurol Scand 2001 ; 104: 171-173.
17. Karni A., Koldzic DN, Bharanidharan P., Khoury SJ, Weiner HL IL-18 is linked to raised IFN-gamma in multiple sclerosis and is induced by activated CD4(+) T cells via CD40-CD40 ligand interactions. J Neuroimmunol 2002 ; 125: 134-140.
18. Huang WX, Huang P., Hillert J. Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis. Mult Scler 2004 ; 10: 482-487.
19. Poser CM, Paty DW, Scheinberg L., et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983 ; 13: 227-231.
20. Polman CH, Reingold SC, Edan G., et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the 'McDonald Criteria'. Ann Neurol 2005 ; 58: 840-846.
21. Hedstrom AK, Baarnhielm M., Olsson T., Alfredsson L. Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis. Neurology 2009 ; 73: 696-701.
22. Roos IM, Kockum I., Hillert J. The interleukin 23 receptor gene in multiple sclerosis: a case-control study. J Neuroimmunol 2008 ; 194: 173-180.
23. de Bakker PI, Yelensky R., Pe'er I., Gabriel SB, Daly MJ, Altshuler D. Efficiency and power in genetic association studies. Nat Genet 2005 ; 37: 1217-1223.
24. Barrett JC, Fry B., Maller J., Daly MJ Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005 ; 21: 263-265.
25. Purcell S., Neale B., Todd-Brown K., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007 ; 81: 559-575.
26. Gabriel SB, Schaffner SF, Nguyen H., et al. The structure of haplotype blocks in the human genome. Science 2002 ; 296: 2225-2229.
27. Purcell S., Cherny SS, Sham PC Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003 ; 19: 149-150.
28. Mandler RN, Davis LE, Jeffery DR, Kornfeld M. Devic's neuromyelitis optica: a clinicopathological study of 8 patients. Ann Neurol 1993 ; 34: 162-168.
29. Brex PA, Ciccarelli O., O'Riordan JI, Sailer M., Thompson AJ, Miller DH A longitudinal study of abnormalities on MRI and disability from multiple sclerosis. N Engl J Med 2002 ; 346: 158-164.
30. Wildbaum G., Youssef S., Grabie N., Karin N. Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis. J Immunol 1998 ; 161: 6368-6374.
31. Shi FD, Takeda K., Akira S., Sarvetnick N., Ljunggren HG IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells. J Immunol 2000 ; 165: 3099-3104.
32. Gu Y., Kuida K., Tsutsui H., et al. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science 1997 ; 275: 206-209.
33. Ghayur T., Banerjee S., Hugunin M., et al. Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature 1997 ; 386: 619-623.
34. Furlan R., Martino G., Galbiati F., et al. Caspase-1 regulates the inflammatory process leading to autoimmune demyelination. J Immunol 1999 ; 163: 2403-2409.
35. Kim SH, Eisenstein M., Reznikov L., et al. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. Proc Natl Acad Sci U S A 2000 ; 97: 1190-1195.
36. Xu D., Chan WL, Leung BP, et al. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells. J Exp Med 1998 ; 188: 1485-1492.
37. Gay FW, Drye TJ, Dick GW, Esiri MM The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion. Brain 1997 ; 120: 1461-1483.
38. Raue HP, Brien JD, Hammarlund E., Slifka MK Activation of virus-specific CD8+ T cells by lipopolysaccharide-induced IL-12 and IL-18. J Immunol 2004 ; 173: 6873-6881.
39. Coyle PK, Brooks BR, Hirsch RL, et al. Cerebrospinal-fluid lymphocyte populations and immune complexes in active multiple sclerosis. Lancet 1980 ; 2: 229-232.
40. Paz A., Fiszer U., Zaborski J., Korlak J., Czlonkowski A., Czlonkowska A. Phenotyping analysis of peripheral blood leukocytes in patients with multiple sclerosis. Eur J Neurol 1998 ; 6: 347-352.
41. Knudsen JH, Kjaersgaard E., Jensen EW, Christensen NJ Percentage of NK-cells in peripheral blood in resting normal subjects is negatively correlated to plasma adrenaline. Scand J Clin Lab Invest 1994 ; 54: 221-225.
42. Karman J., Ling C., Sandor M., Fabry Z. Initiation of immune responses in brain is promoted by local dendritic cells. J Immunol 2004 ; 173: 2353-2361.
43. Stromnes IM, Cerretti LM, Liggitt D., Harris RA, Goverman JM Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat Med 2008 ; 14: 337-342.