A longitudinal study of abnormalities on MRI and disability from multiple sclerosis

New England Journal of Medicine

Volumn 346, Issue 3, 2002, Pages 158-164

  Brex, Peter A ^a   Ciccarelli, Olga ^a   O'Riordan, Jonathon I ^a,b   Sailer, Michael ^c   Thompson, Alan J ^a   Miller, David H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NINEWELLS HOSPITAL   (United Kingdom)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BRAIN SIZE; CLINICAL FEATURE; DISABILITY; EQUIPMENT; FEMALE; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RATING SCALE;

ADOLESCENT; ADULT; BRAIN; BRAIN DISEASES; BRAIN STEM; DISABILITY EVALUATION; FEMALE; HUMANS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; OPTIC NEURITIS; SPINAL CORD DISEASES;

EID: 0037122957     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa011341     Document Type: Article

References (42)

1. Risk of developing multiple sclerosis after uncomplicated optic neuritis: A long-term prospective study
2. A long-term prospective study of optic neuritis: Evaluation of risk factors
3. Disseminated lesions at presentation in patients with optic neuritis
4. Magnetic resonance imaging in clinically isolated lesions of the brain stem
5. Magnetic resonance imaging in isolated noncompressive spinal cord syndromes
6. The significance of brain magnetic resonance imaging abnormalities at presentation with clinically isolated syndromes suggestive of multiple sclerosis: A 5-year follow-up study
7. The 5-year risk of MS after optic neuritis: Experience of the Optic Neuritis Treatment Trial
8. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis
9. The prognostic value of brain MRI in clinically isolated syndromes of the CNS: A 10-year follow-up
10. Effect of early interferon treatment on conversion to definite multiple sclerosis: A randomised study
11. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis
12. Multiple sclerosis
13. Quantitative MRI in patients with clinically isolated syndromes suggestive of demyelination
14. The early risk of multiple sclerosis after optic neuritis
15. The early risk of multiple sclerosis following isolated acute syndromes of the brainstem and spinal cord
16. New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
17. Defining the clinical course of multiple sclerosis: Results of an international survey
18. Rating neurologic impairment in multiple sclerosis: An Expanded Disability Status Scale (EDSS)
19. Can the Expanded Disability Status Scale (EDSS) be assessed by phone?
20. Tests for comparing elements of a correlation matrix
21. A reassessment of the risk of multiple sclerosis developing in patients with optic neuritis after extended follow-up
22. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis
23. Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients
24. The natural history of multiple sclerosis: A geographically based study. 2. Predictive value of the early clinical course
25. Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up
26. Long-term follow-up of isolated optic neuritis: The risk of developing multiple sclerosis, its outcome, and the prognostic role of paraclinical tests
27. Relapses and progression of disability in multiple sclerosis
28. Studies on the natural history of multiple sclerosis. 8. Early prognostic features of the later course of the illness
29. Correlation between NMR scan and brain slice data in multiple sclerosis
30. Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis
31. Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis
32. Histopathology and the blood-cerebrospinal fluid barrier in multiple sclerosis
33. Spinal cord atrophy and disability in multiple sclerosis: A new reproducible and sensitive MR1 method with potential to monitor disease progression
34. Imaging axonal damage of normal-appearing white matter in multiple sclerosis
35. Axonal damage in acute multiple sclerosis lesions
36. Axonal transection in the lesions of multiple sclerosis
37. Temporal development of autoreactive Thl responses and endogenous presentation of self myelin epitopes by central nervous system-resident APCs in Theiler's virus-infected mice
38. The effect of section thickness on MR lesion detection and quantification in multiple sclerosis
39. Interscanner variation in brain MRI lesion load measurements in MS: Implications for clinical trials
40. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial