Design, synthesis and biological evaluation of 3-(4-halophenyl)-3- oxopropanal and their derivatives as novel antibacterial agents

Chemical and Pharmaceutical Bulletin

Volumn 58, Issue 9, 2010, Pages 1127-1131

  Liu, Jinbing ^a,b   Yi, Wei ^b   Hu, Jianming ^a   Wu, Fengyan ^a   Zhao, Liangzhong ^a   Song, Huacan ^b   Wang, Zhihou ^c  

^a SHAOYANG UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c State Drug Administration   (China)

Author keywords

3 (4 halophenyl) 3 oxopropanal; Antibacterial activity; Derivative; Structure activity relationship analysis; Synthesis

Indexed keywords

3 (4 BROMOPHENYL) 3 OXOPROPANAL; 3 (4 BROMOPHENYL) 3 OXOPROPANAL DIOXIME ETHYL ETHER; 3 (4 BROMOPHENYL) 3 OXOPROPANAL DIOXIME METHYL ETHER; 3 (4 BROMOPHENYL) 3 OXOPROPANAL OXIME ETHYL ETHER; 3 (4 BROMOPHENYL) 3 OXOPROPANAL OXIME METHYL ETHER; 3 (4 BROMOPHENYL) 3 OXOPROPANAL SEMICARBAZONE; 3 (4 BROMOPHENYL) 3 OXOPROPANAL THIOSEMICARBAZONE; 3 (4 CHLOROPHENYL) 3 OXOPROPANAL OXIME ETHYL ETHER; 3 (4 CHLOROPHENYL) 3 OXOPROPANAL OXIME METHYL ETHER; 3 (4 FLUOROPHENYL) 3 OXOPROPANAL; 3 (4 FLUOROPHENYL) 3 OXOPROPANAL DIOXIME ETHYL ETHER; 3 (4 FLUOROPHENYL) 3 OXOPROPANAL DIOXIME METHYL ETHER; 3 (4 FLUOROPHENYL) 3 OXOPROPANAL OXIME ETHYL ETHER; 3 (4 FLUOROPHENYL) 3 OXOPROPANAL OXIME METHYL ETHER; 3 (4 FLUOROPHENYL) 3 OXOPROPANAL SEMICARBAZONE; 3 (4 FLUOROPHENYL) 3 OXOPROPANAL THIOSEMICARBAZONE; 3 (4 HALOPHENYL) 3 OXOPROPANAL DERIVATIVE; 3 (4 IODOPHENYL) 3 OXOPROPANAL; 3 (4 IODOPHENYL) 3 OXOPROPANAL DIOXIME ETHYL ETHER; 3 (4 IODOPHENYL) 3 OXOPROPANAL DIOXIME METHYL ETHER; 3 (4 IODOPHENYL) 3 OXOPROPANAL OXIME ETHYL ETHER; 3 (4 IODOPHENYL) 3 OXOPROPANAL OXIME METHYL ETHER; ANTIINFECTIVE AGENT; CLARITHROMYCIN; HOUTTUYNIN; LEVOFLOXACIN; METHOXYAMINE; SODIUM 1 HYDROXY 3 (4 BROMOPHENYL) 3 OXOPROPANE 1 SULFONATE; SODIUM 1 HYDROXY 3 (4 FLUOROPHENYL) 3 OXOPROPANE 1 SULFONATE; SODIUM 1 HYDROXY 3 (4 IODOPHENYL) 3 OXOPROPANE 1 SULFONATE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BACTERIA; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; PYRUVALDEHYDE; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956305283     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.58.1127     Document Type: Article

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