Identification of phenylisoxazolines as novel and viable antibacterial agents active against gram-positive pathogens

Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2003, Pages 284-302

  Barbachyn, Michael R ^a   Cleek, Gary J ^a   Dolak, Lester A ^a   Garmon, Stuart A ^a   Morris, Joel ^b   Seest, Eric P ^a   Thomas, Richard C ^a   Toops, Dana S ^a   Watt, William ^a   Wishka, Donn G ^a   Ford, Charles W ^a   Zurenko, Gary E ^a   Hamel, Judith C ^a   Schaadt, Ronda D ^a   Stapert, Douglas ^a   Yagi, Betty H ^a   Adams, Wade J ^a   Friis, Janice M ^a   Slatter, J Gregory ^a   Sams, James P ^a   Oien, Nancee L ^a   Zaya, Matthew J ^a   Wienkers, Larry C ^a   Wynalda, Michael A ^a   more..

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ISOXAZOLINE DERIVATIVE; LINEZOLID; OXAZOLIDINONE DERIVATIVE; PHENYLISOXAZOLINE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL BOND; DRUG EFFICACY; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFECTION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; BENZENE DERIVATIVES; BIOLOGICAL AVAILABILITY; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; DRUG RESISTANCE, BACTERIAL; GRAM-POSITIVE BACTERIA; HEPATOCYTES; HUMANS; ISOXAZOLES; MALE; MICE; MICROBIAL SENSITIVITY TESTS; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037448380     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020248u     Document Type: Article

References (47)

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