T-3811ME. Quinolone antibacterial

Drugs of the Future

Volumn 24, Issue 12, 1999, Pages 1324-1331

  Graul, A ^a   Rabasseda, X ^a   Castaner J ^a  

^a PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 CYCLOPROPYL 8 DIFLUOROMETHOXY 6 FLUORO 1,4 DIHYDRO 7 (3 METHYL 1 PIPERAZINYL) 4 OXO 3 QUINOLINECARBOXYLIC ACID; 1 CYCLOPROPYL 8 DIFLUOROMETHOXY 7 (1 METHYL 2,3 DIHYDRO 1H ISOINDOL 5 YL) 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; CIPROFLOXACIN; CLINAFLOXACIN; ECENOFLOXACIN; GARENOXACIN; GATIFLOXACIN; GEMIFLOXACIN; GREPAFLOXACIN; LEVOFLOXACIN; LOMEFLOXACIN; MOXIFLOXACIN; NADIFLOXACIN; OFLOXACIN; PAZUFLOXACIN; PRULIFLOXACIN; QUINOLINE DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RUFLOXACIN; SITAFLOXACIN; SPARFLOXACIN; TOSUFLOXACIN TOSILATE; TROVAFLOXACIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG METABOLISM; DRUG SYNTHESIS; HUMAN; MOTOR DYSFUNCTION; NEUROTOXICITY; NONHUMAN;

EID: 0033380623     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1999.024.12.561767     Document Type: Article

References (12)

1. Todo, Y., Hayashi, K., Takahata, M., Watanabe, Y., Narita, H. (Toyama Chemical Co., Ltd.). Quinolonecarboxylic acid derivs. or salts thereof. EP 882725, WO 9729102.
2. Hayashi, H., Todo, Y., Hamamoto, S., Ojima, K., Yamada, M., Kito, T., Takahata, M., Watanabe, Y., Narita, H. T-3811, a novel des-F(6)-quinolone: Synthesis and in vitro activity of 7-(isoindolin-5-yl) derivatives. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F-158.
3. Takahata, M., Mitsuyama, J., Yamashiro, Y., Yonezawa, M., Araki, H., Todo, Y., Minami, S., Watanabe, Y., Narita, H. In vitro and in vivo antimicrobial activities of T-3811ME, a novel desF(6)-quinolone. Antimicrob Agents Chemother 1999, 43: 1077-84.
4. Takahata, M., Shimakura, M., Hori, R., Yonezawa, M., Todo, Y., Minami, S., Watanabe, Y., Narita, H. Efficacy of T-3811ME, a des-F(6)-quinolone, against experimental pneumonia in hamsters, caused by Mycoplasma pneumoniae. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26-29, San Francisco) 1999, Abst F556.
5. Hori, R., Takahata, M., Shimakura, M., Sugiyama, H., Yonezawa, M., Todo, Y., Minami, S., Watanabe, Y., Narita, H. Efficacy of T-3811ME, a novel des-F(6)-quinolone, against experimental meningitis in rabbits caused by penicillin-resistant Streptococcus pneumoniae. 38th Intersci Conf Antimicrob Agents Chemother (Sept 24-27, San Diego) 1998, Abst F-78.
6. Takahata, M., Mitsuyama, J., Yamashiro, Y., Araki, H., Yamada, H., Hayakawa, H., Todo, Y., Minami, S., Watanabe, Y., Narita, H. T-3811, a novel des-F(6)-quinolone: Study of pharma-cokinetics in animals. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F-160.
7. Furuhata, K., Fukuda, H., Nakamura, T., Morita, Y., Arai, H., Todo, Y., Watanabe, Y., Narita, H. Pharmacological evaluation of T3811ME: Toxicity to the central nervous system. 39th Intersci Conf Antimicrob Agents Chemother (Sept 26-29, San Francisco) 1999, Abst F555.
8. Furuhata, K., Fukuda, H., Shimamoto, A., Arai, H., Todo, Y., Watanabe, Y., Narita, H. Pharmacological evaluation of T-3811ME: Toxicity on articular chondrocytes in vitro. 38th Intersci Conf Antimicrob Agents Chemother (Sept 24-27, San Diego) 1998, Abst F-77.
9. Furuhata, K., Soumi, K., Matsumoto, J., Horikawa, A., Nojima, N., Arai, H., Todo, Y., Watanabe, Y., Narita, H. T-3811, a novel des-F(6)-quinolone: Comparative studies of the adverse reactions associated with quinolones. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F-161.
10. Nagai, A., Takahata, M., Miyazaki, M., Kawamura, Y., Kodama, T., Todo, Y., Watanabe, Y., Narita, H. T-3811, a novel des-F(6)-quinolone: Toxicological evaluation. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F-162.
11. Bristol-Myers Squibb begins phase II testing of inlicensed quinolone. DailyDrugNews.com (Daily Essentials) November 12, 1999.
12. Takahata, M., Mitsuyama, J., Yamashiro, Y., Yonezawa, M., Araki, H., Yamada, H., Todo, Y., Minami, S., Watanabe, Y., Marita, H. T-3811, a novel des-F(6)-quinolone: In vitro and in vivo antimicrobial activities. 37th Intersci Conf Antimicrob Agents Chemother (Sept 28-Oct 1, Toronto) 1997, Abst F-159.