Potent inhibitors of lipoprotein-associated phospholipase A2: Benzaldehyde O-heterocycle-4-carbonyloxime

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 21, 2006, Pages 5576-5579

  Jeong, Hyung Jae ^a   Park, Yong Dae ^a,b   Park, Ho Yong ^a   Jeong, Il Yun ^c   Jeong, Tae Sook ^a   Lee, Woo Song ^a,b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Korea Atomic Energy Research Institute   (South Korea)

Author keywords

Lp PLA2 inhibitor

Indexed keywords

BENZALDEHYDE DERIVATIVE; FUNCTIONAL GROUP; LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A 2 INHIBITOR; OXIME DERIVATIVE; PHOSPHOLIPASE; PHOSPHOLIPASE A2 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; HUMAN; IC 50; IN VITRO STUDY; LIPOPHILICITY; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; BENZALDEHYDES; HUMANS; OXIMES; PHOSPHOLIPASES A;

EID: 33748759618     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.031     Document Type: Article

References (15)

1. Macphee C.H., Moores K.E., Boyd H.F., Dhanak D., Ife R.J., Leach C.A., Leake D.S., Milliner K.J., Patterson R.A., Suckling K.E., Tew D.G., and Hickey D.M.B. Biochem. J. 338 (1999) 479
2. Stafforini D.M., McIntyre T.M., Zimmerman G.A., and Prescott S.M. J. Bio. Chem. 272 (1997) 17895
3. Macphee C.H. Curr. Opin. Pharmacol. 1 (2001) 121-125
4. Häkkinen T., Luoma J.S., Hiltunen M.O., Macphee C.H., Milliner K.J., Patel L., Rice S.Q., Tew D.G., Karkola K., and Ylä-Herttuala S. Arterioscler. Thromb. Vasc. Biol. 19 (1999) 2909
5. Benson, G. M.; Grimsditch, D.; Milliner, K.; Moores, K.; Body, H.; Tew, D.; Hickey, D.; Ife, R.; Suckling, K.; Macphee, C. XIIth Internation Symposium on Athelosclerosis Sweden Jun 25-29 2000.
6. Tjoelker L.W., Eberhardt C., Unger J., Trong H.L., Zimmerman G.A., Mclntyre T.M., Stafforini D.M., Prescott S.M., and Gray P.W. J. Biol. Chem. 270 (1995) 25481
7. Thirkettle J., Alvarez E., Boyd H., Brown M., Diez E., Hueso J., Elson S., Fulston M., Gershater C., Morata M.L., Perez P., Ready S., Sanchez-Puelles J.M., Sheridan R., Stefanska A., and Warr S. J. Antibiot. 53 (2000) 664
8. Busby D.J., Copley R.C., Hueso J.A., Readshaw S.A., and Rivera A. J. Antibiot. 53 (2000) 670
9. Thirkettle J. J. Antibiot. 53 (2000) 733
10. Boyd H.F., Flynn S.T., Hickey D.M.B., Ife R.J., Jones M., Leach C.A., Macphee C.H., Milliner K.J., Rawlings A., Slingsby B.P., Smith S.A., Stansfield I.G., Tew D.G., and Theobald C.J. Bioorg. Med. Chem. Lett. 10 (2000) 395
11. Blackie J.A., Bloomer J.C., Brown M.J.B., Cheng H.Y., Hammond B., Hickey D.M.B., Ife R.J., Leach C.A., Lewis V.A., Macphee C.H., Milliner K.J., Moores K.E., Pinto I.L., Smith S.A., Stansfield I.G., Stanway S.J., Taylor M.A., and Theobald C.J. Bioorg. Med. Chem. Lett. 13 (2003) 1067
12. Jeong T.S., Kim M.J., Yu H., Kim K.S., Choi J.K., Kim S.S., and Lee W.S. Bioorg. Med. Chem. Lett. 15 (2005) 1525 and references cited therein
13. Cho B.R., Chung H.S., and Cho N.S. J. Org. Chem. 63 (1998) 4685
14. Boyd H.F., Fell S.C.M., Flynn S.T., Hickey D.M.B., Ife R.J., Leach C.A., Macphee C.H., Milliner K.J., Moores K.E., Pinto I.L., Porter R.A., Rawlings D.A., Smith S.A., Stansfield I.G., Tew D.G., Theobald C.J., and Whittaker C.M. Bioorg. Med. Chem. Lett. 10 (2000) 2557
15. Ghomashchi F., Loo R., Balsinde J., Bartoli F., Apitz-Castro R., Clark J.D., Dennis D.A., and Gelb M.H. Biochem. Biophys. Acta 1420 (1999) 45