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Volumn 7, Issue 9, 2010, Pages 3190-3198

Effects of Intramuscular Testosterone Undecanoate on Body Composition and Bone Mineral Density in Female-to-Male Transsexuals

Author keywords

Body composition; Bone mineral density; Cross sex hormone treatment; Testosterone therapy in female to male transsexuals; Transsexuals

Indexed keywords

ALANINE AMINOTRANSFERASE; ESTRADIOL; FOLLITROPIN; GAMMA GLUTAMYLTRANSFERASE; GONADOTROPIN; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN; LUTEINIZING HORMONE; PRASTERONE SULFATE; PROLACTIN; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; TESTOSTERONE UNDECANOATE; TRIACYLGLYCEROL;

EID: 77956284511     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2010.01912.x     Document Type: Article
Times cited : (116)

References (56)
  • 1
    • 0002870562 scopus 로고
    • Endocrine treatment of male and female transsexualism
    • Green R, Money J. eds., Baltimore, MD, Johns Hopkins Press
    • Hamburger C. Endocrine treatment of male and female transsexualism. Transsexualism and sex reassignment 1969, 291-307. Green RMoney J. eds., Baltimore, MD, Johns Hopkins Press
    • (1969) Transsexualism and sex reassignment , pp. 291-307
    • Hamburger, C.1
  • 2
    • 85031335739 scopus 로고    scopus 로고
    • Standards of Care, 6th version
    • The World Professional Association for Transgender Health, Available at: (accessed June 9, 2010
    • Standards of Care, 6th version. 2008, http://www.wpath.org/publications_standards.cfm, The World Professional Association for Transgender Health, Available at: (accessed June 9, 2010
    • (2008)
  • 4
    • 70649099373 scopus 로고    scopus 로고
    • Sexual functioning in transsexuals following hormone therapy and genital surgery: A review
    • Klein C, Gorzalka BB. Sexual functioning in transsexuals following hormone therapy and genital surgery: A review. J Sex Med 2009, 11:2922-39.
    • (2009) J Sex Med , vol.11 , pp. 2922-2939
    • Klein, C.1    Gorzalka, B.B.2
  • 5
    • 0041382675 scopus 로고    scopus 로고
    • Endocrine treatment of transsexual people: A review of treatment regimens, outcomes, and adverse effects
    • Moore E, Wisniewski A, Dobs A. Endocrine treatment of transsexual people: A review of treatment regimens, outcomes, and adverse effects. J Clin Endocrinol Metab 2003, 88:3467-73.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3467-3473
    • Moore, E.1    Wisniewski, A.2    Dobs, A.3
  • 6
    • 0019203759 scopus 로고
    • Endocrine management of transsexual. Hormonal profiles of serum prolactin, testosterone, and estradiol
    • Futterweit W. Endocrine management of transsexual. Hormonal profiles of serum prolactin, testosterone, and estradiol. N Y State J Med 1980, 80:1260-4.
    • (1980) N Y State J Med , vol.80 , pp. 1260-1264
    • Futterweit, W.1
  • 7
    • 0024448783 scopus 로고
    • Mortality and morbidity in transsexual patients with cross-gender hormone treatment
    • Asscheman H, Gooren LJ, Eklund P. Mortality and morbidity in transsexual patients with cross-gender hormone treatment. Metabolism 1989, 38:869-73.
    • (1989) Metabolism , vol.38 , pp. 869-873
    • Asscheman, H.1    Gooren, L.J.2    Eklund, P.3
  • 8
    • 0030809728 scopus 로고    scopus 로고
    • Mortality and morbidity in transsexual subjects treated with cross-sex hormones
    • Van Kesteren P, Asscheman H, Megens J, Gooren LJ. Mortality and morbidity in transsexual subjects treated with cross-sex hormones. Clin Endocrinol (Oxf) 1997, 47:337-42.
    • (1997) Clin Endocrinol (Oxf) , vol.47 , pp. 337-342
    • Van Kesteren, P.1    Asscheman, H.2    Megens, J.3    Gooren, L.J.4
  • 9
    • 0034816709 scopus 로고    scopus 로고
    • A psycho-endocrinological overview of transsexualism
    • Michel A, Mormont C, Legros J. A psycho-endocrinological overview of transsexualism. Eur J Endocrinol 2001, 145:365-76.
    • (2001) Eur J Endocrinol , vol.145 , pp. 365-376
    • Michel, A.1    Mormont, C.2    Legros, J.3
  • 10
    • 0141504979 scopus 로고    scopus 로고
    • Endocrine intervention for transsexuals
    • Levy A, Crown A, Reid R. Endocrine intervention for transsexuals. Clin Endocrinol (Oxf) 2003, 59:409-18.
    • (2003) Clin Endocrinol (Oxf) , vol.59 , pp. 409-418
    • Levy, A.1    Crown, A.2    Reid, R.3
  • 11
    • 53249145792 scopus 로고    scopus 로고
    • Hormone-related tumors in transsexuals receiving treatment with cross-sex hormones
    • Mueller A, Gooren L. Hormone-related tumors in transsexuals receiving treatment with cross-sex hormones. Eur J Endocrinol 2008, 159:197-202.
    • (2008) Eur J Endocrinol , vol.159 , pp. 197-202
    • Mueller, A.1    Gooren, L.2
  • 12
    • 27944455324 scopus 로고    scopus 로고
    • Hormone treatment of the adult transsexual patient
    • suppl
    • Gooren LJ. Hormone treatment of the adult transsexual patient. Horm Res 2005, 64(2):31-6. suppl
    • (2005) Horm Res , vol.64 , Issue.2 , pp. 31-36
    • Gooren, L.J.1
  • 13
    • 23844468548 scopus 로고    scopus 로고
    • Nebido: A long-acting injectable testosterone for the treatment of male hypogonadism
    • Harle L, Basaria S, Dobs AS. Nebido: A long-acting injectable testosterone for the treatment of male hypogonadism. Expert Opin Pharmacother 2005, 6:1751-9.
    • (2005) Expert Opin Pharmacother , vol.6 , pp. 1751-1759
    • Harle, L.1    Basaria, S.2    Dobs, A.S.3
  • 14
    • 33845383204 scopus 로고    scopus 로고
    • Treatment of sexual dysfunction of hypogonadal patients with long-acting testosterone undecanoate (Nebido)
    • Yassin AA, Saad F. Treatment of sexual dysfunction of hypogonadal patients with long-acting testosterone undecanoate (Nebido). World J Urol 2006, 24:639-44.
    • (2006) World J Urol , vol.24 , pp. 639-644
    • Yassin, A.A.1    Saad, F.2
  • 15
    • 33747356206 scopus 로고    scopus 로고
    • Testosterone treatment comes of age: New options for hypogonadal men
    • Nieschlag E. Testosterone treatment comes of age: New options for hypogonadal men. Clin Endocrinol (Oxf) 2006, 65:275-81.
    • (2006) Clin Endocrinol (Oxf) , vol.65 , pp. 275-281
    • Nieschlag, E.1
  • 17
    • 34548301929 scopus 로고    scopus 로고
    • Long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals
    • Jacobeit JW, Gooren LJ, Schulte HM. Long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals. J Sex Med 2007, 4:1479-84.
    • (2007) J Sex Med , vol.4 , pp. 1479-1484
    • Jacobeit, J.W.1    Gooren, L.J.2    Schulte, H.M.3
  • 18
    • 34548714322 scopus 로고    scopus 로고
    • Long-term administration of testosterone undecanoate every 3 months for testosterone supplementation in female-to-male transsexuals
    • Mueller A, Kiesewetter F, Binder H, Beckmann MW, Dittrich R. Long-term administration of testosterone undecanoate every 3 months for testosterone supplementation in female-to-male transsexuals. J Clin Endocrinol Metab 2007, 92:3470-5.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3470-3475
    • Mueller, A.1    Kiesewetter, F.2    Binder, H.3    Beckmann, M.W.4    Dittrich, R.5
  • 19
    • 70449708079 scopus 로고    scopus 로고
    • Safety aspects of 36 months of administration of long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals
    • Jacobeit JW, Gooren LJ, Schulte HM. Safety aspects of 36 months of administration of long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals. Eur J Endocrinol 2009, 161:795-8.
    • (2009) Eur J Endocrinol , vol.161 , pp. 795-798
    • Jacobeit, J.W.1    Gooren, L.J.2    Schulte, H.M.3
  • 23
    • 68349143256 scopus 로고    scopus 로고
    • Effects of transdermal testosterone or oral dydrogesterone on hypoactive sexual desire disorder in transsexual women: Results of a pilot study
    • Kronawitter D, Gooren LJ, Zollver H, Oppelt PG, Beckmann MM, Dittrich R, Mueller A. Effects of transdermal testosterone or oral dydrogesterone on hypoactive sexual desire disorder in transsexual women: Results of a pilot study. Eur J Endocrinol 2009, 161:363-8.
    • (2009) Eur J Endocrinol , vol.161 , pp. 363-368
    • Kronawitter, D.1    Gooren, L.J.2    Zollver, H.3    Oppelt, P.G.4    Beckmann, M.M.5    Dittrich, R.6    Mueller, A.7
  • 24
    • 22744445113 scopus 로고    scopus 로고
    • High dose estrogen treatment increases bone mineral density in male-to-female transsexuals receiving gonadotropin-releasing hormone agonist in the absence of testosterone
    • Mueller A, Dittrich R, Binder H, Kuehnel W, Maltaris T, Hoffmann I, Beckmann MW. High dose estrogen treatment increases bone mineral density in male-to-female transsexuals receiving gonadotropin-releasing hormone agonist in the absence of testosterone. Eur J Endocrinol 2005, 153:107-13.
    • (2005) Eur J Endocrinol , vol.153 , pp. 107-113
    • Mueller, A.1    Dittrich, R.2    Binder, H.3    Kuehnel, W.4    Maltaris, T.5    Hoffmann, I.6    Beckmann, M.W.7
  • 25
    • 33646236829 scopus 로고    scopus 로고
    • Effects on the male endocrine system of long-term treatment with gonadotropin-releasing hormone agonists and estrogens in male-to-female transsexuals
    • Mueller A, Binder H, Cupisti S, Hoffmann I, Beckmann MW, Dittrich R. Effects on the male endocrine system of long-term treatment with gonadotropin-releasing hormone agonists and estrogens in male-to-female transsexuals. Horm Metab Res 2006, 38:183-7.
    • (2006) Horm Metab Res , vol.38 , pp. 183-187
    • Mueller, A.1    Binder, H.2    Cupisti, S.3    Hoffmann, I.4    Beckmann, M.W.5    Dittrich, R.6
  • 27
    • 43149087991 scopus 로고    scopus 로고
    • Body mass index and ovarian function are associated with endocrine and metabolic abnormalities in women with hyperandrogenic syndrome
    • Cupisti S, Kajaia N, Dittrich R, Duezenli H, Beckmann MW, Mueller A. Body mass index and ovarian function are associated with endocrine and metabolic abnormalities in women with hyperandrogenic syndrome. Eur J Endocrinol 2008, 158:711-9.
    • (2008) Eur J Endocrinol , vol.158 , pp. 711-719
    • Cupisti, S.1    Kajaia, N.2    Dittrich, R.3    Duezenli, H.4    Beckmann, M.W.5    Mueller, A.6
  • 30
    • 38149072283 scopus 로고    scopus 로고
    • Long-term treatment of transsexuals with cross-sex hormones: Extensive personal experience
    • Gooren LJ, Giltay EJ, Bunck MC. Long-term treatment of transsexuals with cross-sex hormones: Extensive personal experience. J Clin Endocrinol Metab 2008, 93:19-25.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 19-25
    • Gooren, L.J.1    Giltay, E.J.2    Bunck, M.C.3
  • 31
    • 42549148990 scopus 로고    scopus 로고
    • Olympic sports and transsexuals
    • Gooren LJ. Olympic sports and transsexuals. Asian J Androl 2008, 10:427-32.
    • (2008) Asian J Androl , vol.10 , pp. 427-432
    • Gooren, L.J.1
  • 32
    • 0032986811 scopus 로고    scopus 로고
    • Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals
    • Elbers JM, Asscheman H, Seidell JC, Gooren LJ. Effects of sex steroid hormones on regional fat depots as assessed by magnetic resonance imaging in transsexuals. Am J Physiol 1999, 276:E317-25.
    • (1999) Am J Physiol , vol.276
    • Elbers, J.M.1    Asscheman, H.2    Seidell, J.C.3    Gooren, L.J.4
  • 34
    • 41549149175 scopus 로고    scopus 로고
    • Review of studies of androgen treatment of female-to-male transsexuals: Effects and risks of administration of androgens to females
    • Gooren LJ, Giltay EJ. Review of studies of androgen treatment of female-to-male transsexuals: Effects and risks of administration of androgens to females. J Sex Med 2008, 5:765-76.
    • (2008) J Sex Med , vol.5 , pp. 765-776
    • Gooren, L.J.1    Giltay, E.J.2
  • 36
    • 0028866916 scopus 로고
    • Segregation analysis and variance components analysis of bone mineral density in healthy families
    • Guéguen R, Jouanny P, Guillemin F, Kuntz C, Pourel J, Siest G. Segregation analysis and variance components analysis of bone mineral density in healthy families. J Bone Miner Res 1995, 10:2017-22.
    • (1995) J Bone Miner Res , vol.10 , pp. 2017-2022
    • Guéguen, R.1    Jouanny, P.2    Guillemin, F.3    Kuntz, C.4    Pourel, J.5    Siest, G.6
  • 37
    • 0020014985 scopus 로고
    • The effect of physical activity on the skeleton
    • Falch JA. The effect of physical activity on the skeleton. Scand J Soc Med Suppl 1982, 29:55-8.
    • (1982) Scand J Soc Med Suppl , vol.29 , pp. 55-58
    • Falch, J.A.1
  • 38
    • 22344440137 scopus 로고    scopus 로고
    • Premenopausal bone health assessment
    • Lewiecki EM. Premenopausal bone health assessment. Curr Rheumatol Rep 2005, 7:46-52.
    • (2005) Curr Rheumatol Rep , vol.7 , pp. 46-52
    • Lewiecki, E.M.1
  • 40
    • 0032572929 scopus 로고    scopus 로고
    • Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency
    • Bilezikan JP, Morishima A, Bell J, Brumbach MM. Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med 1998, 339:599-603.
    • (1998) N Engl J Med , vol.339 , pp. 599-603
    • Bilezikan, J.P.1    Morishima, A.2    Bell, J.3    Brumbach, M.M.4
  • 43
    • 0029861744 scopus 로고    scopus 로고
    • The effect of androgen treatment on bone metabolism in female-to-male transsexuals
    • Lips P, van Kesteren PJ, Asscheman H, Gooren LJ. The effect of androgen treatment on bone metabolism in female-to-male transsexuals. J Bone Miner Res 1996, 11:1769-73.
    • (1996) J Bone Miner Res , vol.11 , pp. 1769-1773
    • Lips, P.1    van Kesteren, P.J.2    Asscheman, H.3    Gooren, L.J.4
  • 44
    • 0030685090 scopus 로고    scopus 로고
    • Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo Study
    • Greendale GA, Edelstein S, Barrett-Connor E. Endogenous sex steroids and bone mineral density in older women and men: The Rancho Bernardo Study. J Bone Miner Res 1997, 12:1833-43.
    • (1997) J Bone Miner Res , vol.12 , pp. 1833-1843
    • Greendale, G.A.1    Edelstein, S.2    Barrett-Connor, E.3
  • 45
    • 0033304569 scopus 로고    scopus 로고
    • Hormonal and biochemical parameters in the determination of osteoporosis in elderly men
    • Center JR, Nguyen TV, Sambrook PN, Eisman JA. Hormonal and biochemical parameters in the determination of osteoporosis in elderly men. J Clin Endocrinol Metab 1999, 84:3626-35.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3626-3635
    • Center, J.R.1    Nguyen, T.V.2    Sambrook, P.N.3    Eisman, J.A.4
  • 46
    • 0031756218 scopus 로고    scopus 로고
    • Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen
    • Khosla S, Melton LJ, Atkinson EJ, O'Fallon WM, Klee GG, Riggs BL. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen. J Clin Endocrinol Metab 1998, 83:2266-74.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2266-2274
    • Khosla, S.1    Melton, L.J.2    Atkinson, E.J.3    O'Fallon, W.M.4    Klee, G.G.5    Riggs, B.L.6
  • 47
    • 0030931083 scopus 로고    scopus 로고
    • Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens
    • Slemenda CW, Longcope C, Zhou L, Hui SL, Peacock M, Johnston CC. Sex steroids and bone mass in older men. Positive associations with serum estrogens and negative associations with androgens. J Clin Invest 1997, 100:1755-9.
    • (1997) J Clin Invest , vol.100 , pp. 1755-1759
    • Slemenda, C.W.1    Longcope, C.2    Zhou, L.3    Hui, S.L.4    Peacock, M.5    Johnston, C.C.6
  • 48
    • 34547927414 scopus 로고    scopus 로고
    • Cross-sex pattern of bone mineral density in early onset gender identity disorder
    • Haraldsen IR, Haug E, Falch J, Egeland T, Opjordsmoen S. Cross-sex pattern of bone mineral density in early onset gender identity disorder. Horm Behav 2007, 52:334-43.
    • (2007) Horm Behav , vol.52 , pp. 334-343
    • Haraldsen, I.R.1    Haug, E.2    Falch, J.3    Egeland, T.4    Opjordsmoen, S.5
  • 49
    • 0035083718 scopus 로고    scopus 로고
    • Genetic control of bone density and turnover: Role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes
    • Brown MA, Haughton MA, Grant SF, Gunnell AS, Henderson NK, Eisman JA. Genetic control of bone density and turnover: Role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes. J Bone Miner Res 2001, 16:758-64.
    • (2001) J Bone Miner Res , vol.16 , pp. 758-764
    • Brown, M.A.1    Haughton, M.A.2    Grant, S.F.3    Gunnell, A.S.4    Henderson, N.K.5    Eisman, J.A.6
  • 50
    • 0141636356 scopus 로고    scopus 로고
    • Bone mass, bone turnover, vitamin D, and estrogen receptor gene polymorphisms in male to female transsexuals: Effects of estrogenic treatment on bone metabolism of the male
    • Sosa M, Jódar E, Arbelo E, Domínguez C, Saavedra P, Torres A, Salido E, de Tejada MJ, Hernández D. Bone mass, bone turnover, vitamin D, and estrogen receptor gene polymorphisms in male to female transsexuals: Effects of estrogenic treatment on bone metabolism of the male. J Clin Densitom 2003, 6:297-304.
    • (2003) J Clin Densitom , vol.6 , pp. 297-304
    • Sosa, M.1    Jódar, E.2    Arbelo, E.3    Domínguez, C.4    Saavedra, P.5    Torres, A.6    Salido, E.7    de Tejada, M.J.8    Hernández, D.9
  • 51
    • 52049120377 scopus 로고    scopus 로고
    • Increased arterial stiffness in female-to-male transsexuals treated with androgen
    • Emi Y, Adachi M, Sasaki A, Nakamura Y, Nakatsuka M. Increased arterial stiffness in female-to-male transsexuals treated with androgen. J Obstet Gynaecol Res 2008, 5:890-7.
    • (2008) J Obstet Gynaecol Res , vol.5 , pp. 890-897
    • Emi, Y.1    Adachi, M.2    Sasaki, A.3    Nakamura, Y.4    Nakatsuka, M.5
  • 53
    • 0031931234 scopus 로고    scopus 로고
    • Long-term follow-up of bone mineral density and bone metabolism in transsexuals treated with cross-sex hormones
    • Van Kesteren P, Lips P, Gooren LJ, Asscheman H, Megens J. Long-term follow-up of bone mineral density and bone metabolism in transsexuals treated with cross-sex hormones. Clin Endocrinol (Oxf) 1998, 48:347-54.
    • (1998) Clin Endocrinol (Oxf) , vol.48 , pp. 347-354
    • Van Kesteren, P.1    Lips, P.2    Gooren, L.J.3    Asscheman, H.4    Megens, J.5
  • 54
    • 0031048019 scopus 로고    scopus 로고
    • Effects of hormone deficiency, androgen therapy and calcium supplementation on bone mineral density in female transsexuals
    • Goh HH, Ratnam SS. Effects of hormone deficiency, androgen therapy and calcium supplementation on bone mineral density in female transsexuals. Maturitas 1997, 26:45-52.
    • (1997) Maturitas , vol.26 , pp. 45-52
    • Goh, H.H.1    Ratnam, S.S.2
  • 55
    • 34548335117 scopus 로고    scopus 로고
    • Gender identity disorders: Diagnostic and surgical aspects
    • Sohn M, Bosinski HA. Gender identity disorders: Diagnostic and surgical aspects. J Sex Med 2007, 5:1193-207.
    • (2007) J Sex Med , vol.5 , pp. 1193-1207
    • Sohn, M.1    Bosinski, H.A.2
  • 56
    • 77953925104 scopus 로고    scopus 로고
    • Combined hysterectomy/salpingo-oophorectomy and mastectomy is a safe and valuable procedure for female-to-male transsexuals
    • Ott J, van Trotsenburg M, Kaufmann U, Schrögendorfer K, Haslik W, Huber JC, Wenzl R. Combined hysterectomy/salpingo-oophorectomy and mastectomy is a safe and valuable procedure for female-to-male transsexuals. J Sex Med 2010, 7:2130-8.
    • (2010) J Sex Med , vol.7 , pp. 2130-2138
    • Ott, J.1    van Trotsenburg, M.2    Kaufmann, U.3    Schrögendorfer, K.4    Haslik, W.5    Huber, J.C.6    Wenzl, R.7


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