Increased arterial stiffness in female-to-male transsexuals treated with androgen

Journal of Obstetrics and Gynaecology Research

Volumn 34, Issue 5, 2008, Pages 890-897

  Emi, Yayoi ^a,b   Adachi, Miwa ^b,c   Sasaki, Aiko ^b,c   Nakamura, Yoshio ^b,c   Nakatsuka, Mikiya ^a,b  

^a OKAYAMA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY HOSPITAL   (Japan)

^c OKAYAMA UNIVERSITY   (Japan)

Author keywords

Androgen; Arterial stiffness; Plethysmography; Pulse wave velocity; Transsexuals

Indexed keywords

ANDROGEN; TESTOSTERONE ESTER;

ADULT; ANDROGEN THERAPY; ANKLE BRACHIAL INDEX; ARTERIAL STIFFNESS; ARTERY BLOOD FLOW; ARTICLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE MONITORING; BODY MASS; BODY PLETHYSMOGRAPHY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; FEMALE TO MALE TRANSSEXUAL; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; SYSTOLIC BLOOD PRESSURE;

ADULT; BLOOD PRESSURE; BRACHIAL ARTERY; ESTRADIOL; FEMALE; HEART RATE; HUMANS; PLETHYSMOGRAPHY; TESTOSTERONE; TRANSSEXUALISM; YOUNG ADULT;

EID: 52049120377     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/j.1447-0756.2008.00857.x     Document Type: Article

References (41)

1. Goh HH, Loke DF, Ratnam SS. The impact of long-term testosterone replacement therapy on lipid and lipoprotein profiles in women. Maturitas 1995 21 : 65 70.
2. Liu PY, Death AK, Handelsman DJ. Androgens and cardiovascular disease. Endocr Rev 2003 24 : 313 340.
3. Wojcicki J, Tustanowski S, Samochowiec L. Endocrine functions in atherosclerotic rabbits. Pol J Pharmacol Pharm 1989 41 : 109 113.
4. Larsen BA, Nordestgaard BG, Stender S, Kjeldsen K. Effects of testosterone on atherogenesis in cholesterol-fed rabbits with similar plasma cholesterol levels. Atherosclerosis 1993 99 : 79 86.
5. Toda T, Toda Y, Cho BH, Kummerow FA. Ultrastructural changes in the comb and aorta of chicks fed excess testosterone. Atherosclerosis 1984 51 : 47 57.
6. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circ 2007 115 : 459 467.
7. Takata M, Nakatsuka M, Kudo T. Differential blood flow in uterine, ophthalmic, and brachial arteries of preeclamptic women. Obstet Gynecol 2002 100 : 931 939.
8. Giltay EJ, Lambert J, Gooren LJ, Elbers JM, Steyn M, Stehouwer CD. Sex steroids, insulin, and arterial stiffness in women and Men. Hypertension 1999 34 : 590 597.
9. Weber T, Auer J, O'Rourke MF et al. Arterial stiffness, wave reflections, and the risk of coronary artery disease. Circle 2004 109 : 184 189.
10. Kashyap SR, Defronzo RA. The insulin resistance syndrome: physiological considerations. Diab Vasc Dis Res 2007 4 : 13 19.
11. Chekir C, Nakatsuka M, Kamada Y, Noguchi S, Sasaki A, Hiramatsu Y. Impaired uterine perfusion associated with metabolic disorders in women with polycystic ovary syndrome. Acta Obstet Gynecol Scand 2005 84 : 189 195.
12. Sartorato P, Zulian E, Benedini S et al. Cardiovascular risk factors and ultrasound evaluation of intima-media thickness at common carotids, carotid bulbs, and femoral and abdominal aorta arteries in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Clin Endocrinol Metab 2007 92 : 1015 1018.
13. Dickerman RD, McConathy WJ, Zachariah NY. Testosterone, sex hormone-binding globulin, lipoproteins, and vascular disease risk. J Cardiovasc Risk 1997 4 : 363 366.
14. Sader MA, Griffiths KA, McCredie RJ, Handelsman DJ, Celermajer DS. Androgenic anabolic steroids and arterial structure and function in male bodybuilders. J Am Coll Cardiol 2001 37 : 224 230.
15. McCredie RJ, McCrohon JA, Turner L, Griffiths KA, Handelsman DJ, Celermajer DS. Vascular reactivity is impaired in genetic females taking high-dose androgens. J Am Coll Cardiol 1998 32 : 1331 1335.
16. Nakatsuka M, Asagiri K, Noguchi S, Habara T, Kudo T. Nafamostat mesilate, a serine protease inhibitor, suppresses lipopolysaccharide-induced nitric oxide synthesis and apoptosis in cultured human trophoblasts. Life Sci 2000 67 : 1243 1250.
17. Yamashina A, Tomiyama H, Takeda K et al. Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. Hypertens Res 2002 25 : 359 364.
18. Matsui Y, Kario K, Ishikawa J, Eguchi K, Hoshide S, Shimada K. Reproducibility of arterial stiffness indices (pulse wave velocity and augmentation index) simultaneously assessed by automated pulse wave analysis and their associated risk factors in essential hypertensive patients. Hypertens Res 2004 27 : 851 857.
19. Sacks D, Bakal CW, Beatty PT et al. Standards Division of the Society of Interventional Radiology. Position statement on the use of the ankle brachial index in the evaluation of patients with peripheral vascular disease. A consensus statement developed by the Standards Division of the Society of Interventional Radiology. J Vasc Interv Radiol 2003 14 : S389.
20. Celermajer DS, Sorensen KE, Gooch VM et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992 340 : 1111 1115.
21. Asmar R. Effect of antihypertensive agents on arterial stiffness as evaluated by pulse wave velocity: clinical implications. Am J Cardiovasc Drugs 2001 1 : 387 397.
22. London GM, Marchais SJ, Guerin AP, Pannier B. Arterial stiffness: pathophysiology and clinical impact. Clin Exp Hypertens 2004 26 : 689 699.
23. Nichols WW. Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms. Am J Hypertens 2005 18 : 3S 10S.
24. Wilson AM, O'Neal D, Nelson CL, Prior DL, Best JD, Jenkins AJ. Comparison of arterial assessments in low and high vascular disease risk groups. Am J Hypertens 2004 17 : 285 291.
25. Ferenchick GS. Anabolic/androgenic steroid abuse and thrombosis: is there a connection? Med Hypotheses 1991 35 : 27 31.
26. Lane HA, Grace F, Smith JC et al. Impaired vasoreactivity in bodybuilders using androgenic anabolic steroids. Eur J Clin Invest 2006 36 : 483 488.
27. Herman SM, Robinson JT, McCredie RJ, Adams MR, Boyer MJ, Celermajer DS. Androgen deprivation is associated with enhanced endothelium-dependent dilatation in adult men. Arterioscler Thromb Vasc Biol 1997 17 : 2004 2009.
28. Herity NA, Lo S, Lee DP et al. Effect of a change in gender on coronary arterial size: a longitudinal intravascular ultrasound study in transplanted hearts. J Am Coll Cardiol 2003 41 : 1539 1546.
29. Elbers JM, Giltay EJ, Teerlink T et al. Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects. Clin Endocrinol (Oxf) 2003 58 : 562 571.
30. Mueller A, Kiesewetter F, Binder H, Beckmann MW, Dittrich R. Long-term administration of testosterone undecanoate every 3 months for testosterone supplementation in female-to-male transsexuals. J Clin Endocrinol Metab 2007 92 : 3470 3475.
31. Berra M, Armillotta F, D'Emidio L et al. Testosterone decreases adiponectin levels in female to male transsexuals. Asian J Androl 2006 8 : 725 729.
32. van Kesteren PJ, Kooistra T, Lansink M et al. The effects of sex steroids on plasma levels of marker proteins of endothelial cell functioning. Thromb Haemost 1998 79 : 1029 1033.
33. Saijo Y, Utsugi M, Yoshioka E et al. Relationships of C-reactive protein, uric acid, and glomerular filtration rate to arterial stiffness in Japanese subjects. J Hum Hypertens 2005 19 : 907 913.
34. Schachter M. Uric acid and hypertension. Curr Pharm Des 2005 11 : 4139 4143.
35. Zaydun G, Tomiyama H, Hashimoto H et al. Menopause is an independent factor augmenting the age-related increase in arterial stiffness in the early postmenopausal phase. Atherosclerosis 2006 184 : 137 142.
36. Sumino H, Ichikawa S, Kasama S et al. Different effects of oral conjugated estrogen and transdermal estradiol on arterial stiffness and vascular inflammatory markers in postmenopausal women. Atherosclerosis 2006 189 : 436 442.
37. Hougaku H, Fleg JL, Najjar SS et al. Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements. Am J Physiol Endocrinol Metab 2006 290 : E234-E242.
38. Dockery F, Bulpitt CJ, Donaldson M, Fernandez S, Rajkumar C. The relationship between androgens and arterial stiffness in older men. Am Geriatr Soc 2003 51 : 1627 1632.
39. Taquet A, Bonithon-Kopp C, Simon A et al. Relations of cardiovascular risk factors to aortic pulse wave velocity in asymptomatic middle-aged women. Eur J Epidemiol 1993 9 : 298 306.
40. Chen MJ, Yang WS, Yang JH, Chen CL, Ho HN, Yang YS. Relationship between androgen levels and blood pressure in young women with polycystic ovary syndrome. Hypertension 2007 49 : 1442 1447.
41. Asmar R. Effect of antihypertensive agents on arterial stiffness as evaluated by pulse wave velocity: clinical implications. Am J Cardiovasc Drugs 2001 1 : 387 397.