Toxicological evaluation of Z24, a novel indolin-2-ketone compound, in cultured human liver cells using toxicogenomic techniques

International Journal of Toxicology

Volumn 29, Issue 4, 2010, Pages 380-390

  Wang, Quanjun ^a   Zhao, Jianyu ^b   Yang, Baohua ^a   Jiang, Ying ^c   Wu, Chunqi ^a   Zheng, Zhibing ^a   Yu, Shouzhong ^a   Yuan, Benli ^a   Li, Song ^a   Liao, Mingyang ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Mechanism; toxicogenomics; Z24

Indexed keywords

3 [(1H PYRROL 2 YL)METHYLIDENE] 1 (1 PIPERIDINYLMETHYL) 1,3 2H INDOL 2 ONE; CASPASE 3; COMPLEMENTARY DNA; CYTOCHROME C; DEATH RECEPTOR 4; KETONE DERIVATIVE; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG; (3Z)-3-(1H-PYRROL-2-YL)-METHYLLIDENE)-1-(1-(PIPERIDYLMETHYL)-1,3-DIHYDRO-2H-INDOL-2-ONE MESYLATE; MESYLIC ACID DERIVATIVE; PRIMER DNA; PYRROLE DERIVATIVE;

APOPTOSIS; ARTICLE; BIOINFORMATICS; CELL DEATH; CELL LINE; CELL REGENERATION; CONTROLLED STUDY; DNA FRAGMENTATION; ENERGY METABOLISM; GENE EXPRESSION; GENOMICS; HUMAN; HUMAN CELL; INFLAMMATION; LIPID METABOLISM; LIVER CELL; LIVER CELL CARCINOMA; LIVER TOXICITY; MICROARRAY ANALYSIS; TOXICOGENETICS; WESTERN BLOTTING; CELL CULTURE; DNA MICROARRAY; DRUG EFFECTS; LIVER; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOXICITY;

APOPTOSIS; BASE SEQUENCE; BLOTTING, WESTERN; CELLS, CULTURED; DNA PRIMERS; GENOMICS; HUMANS; LIVER; MESYLATES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; PYRROLES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77956283958     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581810370373     Document Type: Article

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