-
1
-
-
0028305614
-
Telomeres: no end in sight
-
Blackburn E.H. Telomeres: no end in sight. Cell 1997, 77:621-623.
-
(1997)
Cell
, vol.77
, pp. 621-623
-
-
Blackburn, E.H.1
-
2
-
-
0021151105
-
The molecular structure of centromers and telomeres
-
Blackburn E.H., Szostak J.W. The molecular structure of centromers and telomeres. Annu. Rev. Biochem. 1984, 53:163-194.
-
(1984)
Annu. Rev. Biochem.
, vol.53
, pp. 163-194
-
-
Blackburn, E.H.1
Szostak, J.W.2
-
3
-
-
0025731583
-
Structure and function of telomeres
-
Blackburn E.H. Structure and function of telomeres. Nature 1991, 350:569-573.
-
(1991)
Nature
, vol.350
, pp. 569-573
-
-
Blackburn, E.H.1
-
4
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn W.C., Counter C.M., Lundberg A.S., Beijersbergen R.L., Brooks M.W., Weinberg R.A. Creation of human tumour cells with defined genetic elements. Nature 1999, 400:464-468.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
5
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim N., Piatyszck M., Prowse K., Harley C., West M., Ho P.L., Coviello G.M., Wright W.E., Shay J.W. Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 266:2011-2015.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.1
Piatyszck, M.2
Prowse, K.3
Harley, C.4
West, M.5
Ho, P.L.6
Coviello, G.M.7
Wright, W.E.8
Shay, J.W.9
-
6
-
-
39849099231
-
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands
-
Cuenca F., Greciano O., Gunaratnam M., Haider S., Munnur D., Nanjunda R., Wilson W.D., Neidle S. Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. Bioorg. Med. Chem. Lett. 2008, 18:1668-1673.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 1668-1673
-
-
Cuenca, F.1
Greciano, O.2
Gunaratnam, M.3
Haider, S.4
Munnur, D.5
Nanjunda, R.6
Wilson, W.D.7
Neidle, S.8
-
7
-
-
0043199578
-
Telomerase maintains telomere structure in normal human cells
-
Masutomi K., Yu E.Y., Khurts S., Ben-Porath I., Currier J.L., Metz G.B., Brooks M.W., Kaneko S., Murakami S., DeCaprio J.A., Weinberg R.A., Stewart S.A., Hahn W.C. Telomerase maintains telomere structure in normal human cells. Cell 2003, 114:241-253.
-
(2003)
Cell
, vol.114
, pp. 241-253
-
-
Masutomi, K.1
Yu, E.Y.2
Khurts, S.3
Ben-Porath, I.4
Currier, J.L.5
Metz, G.B.6
Brooks, M.W.7
Kaneko, S.8
Murakami, S.9
DeCaprio, J.A.10
Weinberg, R.A.11
Stewart, S.A.12
Hahn, W.C.13
-
8
-
-
0037082423
-
Natural and pharmacological regulation of telomerase
-
Mergny J.L., Riou J.F., Mailliet P., Teulade-Fichou M.P., Gilson E. Natural and pharmacological regulation of telomerase. Nucleic Acids Res. 2002, 30:839-865.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 839-865
-
-
Mergny, J.L.1
Riou, J.F.2
Mailliet, P.3
Teulade-Fichou, M.P.4
Gilson, E.5
-
9
-
-
0036241599
-
A G-quadruplex interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity
-
Gowan S.M., Harrison J.R., Patterson L., Valneti M., Read M.A., Neidle S., Kelland L.R. A G-quadruplex interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol. Pharmacol. 2002, 61:1154-1162.
-
(2002)
Mol. Pharmacol.
, vol.61
, pp. 1154-1162
-
-
Gowan, S.M.1
Harrison, J.R.2
Patterson, L.3
Valneti, M.4
Read, M.A.5
Neidle, S.6
Kelland, L.R.7
-
10
-
-
0002205687
-
Life at the end of the chromosome: telomeres and telomerase
-
Cech T.R. Life at the end of the chromosome: telomeres and telomerase. Angew. Chem. Int. Ed. 2000, 39:34-43.
-
(2000)
Angew. Chem. Int. Ed.
, vol.39
, pp. 34-43
-
-
Cech, T.R.1
-
11
-
-
77953381213
-
Structural insights into G-quadruplexes: towards new anticancer drugs
-
Yang D., Okamoto K. Structural insights into G-quadruplexes: towards new anticancer drugs. Future Med. Chem. 2010, 2:619-646.
-
(2010)
Future Med. Chem.
, vol.2
, pp. 619-646
-
-
Yang, D.1
Okamoto, K.2
-
12
-
-
0033530113
-
Human telomerase inhibition by substituted acridine derivatives
-
Harrison R., Gowan S., Kelland L., Neidle S. Human telomerase inhibition by substituted acridine derivatives. Bioorg. Med. Chem. Lett. 1999, 9:2463-2468.
-
(1999)
Bioorg. Med. Chem. Lett.
, vol.9
, pp. 2463-2468
-
-
Harrison, R.1
Gowan, S.2
Kelland, L.3
Neidle, S.4
-
13
-
-
0033524027
-
Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure activity relationships
-
Read M.A., Wood A., Harrison R., Gowan S., Kelland L., Dosanjh H., Neidle S. Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure activity relationships. J. Med. Chem. 1999, 42:4538-4546.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4538-4546
-
-
Read, M.A.1
Wood, A.2
Harrison, R.3
Gowan, S.4
Kelland, L.5
Dosanjh, H.6
Neidle, S.7
-
14
-
-
44349142304
-
Structural basis of DNA quadruplex recognition by an acridine drug
-
Campbell N., Parkinson G., Reszka A., Neidle S. Structural basis of DNA quadruplex recognition by an acridine drug. J. Am. Chem. Soc. 2008, 130:6722-6724.
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 6722-6724
-
-
Campbell, N.1
Parkinson, G.2
Reszka, A.3
Neidle, S.4
-
15
-
-
64349090873
-
Selectivity in ligand recognition of G-quadruplex loops
-
Campbell N., Patel M., Tofa A., Ghosh R., Parkinson G., Neidle S. Selectivity in ligand recognition of G-quadruplex loops. Biochemistry 2009, 48:1675-1680.
-
(2009)
Biochemistry
, vol.48
, pp. 1675-1680
-
-
Campbell, N.1
Patel, M.2
Tofa, A.3
Ghosh, R.4
Parkinson, G.5
Neidle, S.6
-
16
-
-
7044249456
-
Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding
-
Harrison J.R., Reszka A.P., Haider S.M., Romagnoli B., Morrell J., Read M.A., Gowan S.M., Incles C.M., Kelland L.R., Neidle S. Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorg. Med. Chem. Lett. 2004, 14:5845-5849.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 5845-5849
-
-
Harrison, J.R.1
Reszka, A.P.2
Haider, S.M.3
Romagnoli, B.4
Morrell, J.5
Read, M.A.6
Gowan, S.M.7
Incles, C.M.8
Kelland, L.R.9
Neidle, S.10
-
17
-
-
0033524027
-
Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationship
-
Read M.A., Wood A.A., Harrison J.R., Gowan S.M., Kelland L.R., Dosanjh H.S., Niedle S. Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationship. J. Med. Chem. 1999, 42:4538-4546.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4538-4546
-
-
Read, M.A.1
Wood, A.A.2
Harrison, J.R.3
Gowan, S.M.4
Kelland, L.R.5
Dosanjh, H.S.6
Niedle, S.7
-
18
-
-
0032514479
-
1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase
-
Perry P.J., Gowan S.M., Reszka A.P., Polucci P., Jenkins T.C., Kelland L.R., Neidle S. 1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase. J. Med. Chem. 1998, 41:3253-3260.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 3253-3260
-
-
Perry, P.J.1
Gowan, S.M.2
Reszka, A.P.3
Polucci, P.4
Jenkins, T.C.5
Kelland, L.R.6
Neidle, S.7
-
19
-
-
7844223625
-
S. Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones
-
Perry P.J., Reszka A.P., Wood A., Read .A., Gowan M.A., Dosanjh S.M., Trent H.S., Jenkins J.O., Kelland T.C., Neidle L.R. S. Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones. J. Med. Chem. 1998, 41:4873-4884.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 4873-4884
-
-
Perry, P.J.1
Reszka, A.P.2
Wood, A.3
Read, .A.4
Gowan, M.A.5
Dosanjh, S.M.6
Trent, H.S.7
Jenkins, J.O.8
Kelland, T.C.9
Neidle, L.R.10
-
20
-
-
38049007426
-
Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives
-
Zagotto G., Sissi C., Moro S., Ben D., Parkinson G., Fox K., Neidle S., Palumbo M. Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. Bioorg. Med. Chem. 2008, 16:354-361.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 354-361
-
-
Zagotto, G.1
Sissi, C.2
Moro, S.3
Ben, D.4
Parkinson, G.5
Fox, K.6
Neidle, S.7
Palumbo, M.8
-
21
-
-
68349130197
-
Design, synthesis and evaluation of 4,5-disubstituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cell
-
Cuenca F., Moore M.J.B., Johnson K., Guyen B., Cian A. Design, synthesis and evaluation of 4,5-disubstituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cell. Bioorg. Med. Chem. Lett. 2009, 19:5109-5113.
-
(2009)
Bioorg. Med. Chem. Lett.
, vol.19
, pp. 5109-5113
-
-
Cuenca, F.1
Moore, M.J.B.2
Johnson, K.3
Guyen, B.4
Cian, A.5
-
22
-
-
66249109269
-
Structural investigations of acridine derivatives by CoMFA and CoMSIA reveal novel insight into their structures toward DNA G-quadruplex mediated telomerase inhibition and offer a highly predictive 3D model for substituted acridines
-
Zambre V.P., Murumkar P.R., Giridhar R., Yadav M.R. Structural investigations of acridine derivatives by CoMFA and CoMSIA reveal novel insight into their structures toward DNA G-quadruplex mediated telomerase inhibition and offer a highly predictive 3D model for substituted acridines. J. Chem. Inf. Model. 2009, 49:1298-1311.
-
(2009)
J. Chem. Inf. Model.
, vol.49
, pp. 1298-1311
-
-
Zambre, V.P.1
Murumkar, P.R.2
Giridhar, R.3
Yadav, M.R.4
-
23
-
-
58149102483
-
Development of predictive 3D- QSAR CoMFA and CoMSIA models for β-aminohydroxamic acid-derived TACE inhibitors
-
Murumkar P.R., Dasgupta S., Zambre V.P., Giridhar R., Yadav M.R. Development of predictive 3D- QSAR CoMFA and CoMSIA models for β-aminohydroxamic acid-derived TACE inhibitors. Chem. Biol. Drug Des. 2009, 73:97-107.
-
(2009)
Chem. Biol. Drug Des.
, vol.73
, pp. 97-107
-
-
Murumkar, P.R.1
Dasgupta, S.2
Zambre, V.P.3
Giridhar, R.4
Yadav, M.R.5
-
24
-
-
40449129841
-
3D-quantitative structure-activity relationship studies on benzothiadiazepine hydroxamates as inhibitors of tumor necrosis factor-alpha converting enzyme
-
Murumkar P.R., Giridhar R., Yadav M.R. 3D-quantitative structure-activity relationship studies on benzothiadiazepine hydroxamates as inhibitors of tumor necrosis factor-alpha converting enzyme. Chem. Biol. Drug Des. 2008, 71:363-373.
-
(2008)
Chem. Biol. Drug Des.
, vol.71
, pp. 363-373
-
-
Murumkar, P.R.1
Giridhar, R.2
Yadav, M.R.3
-
25
-
-
33144490688
-
3D-QSAR studies of farnesyltransferase inhibitors: a comparative molecular field analysis approach
-
Puntambekar D.S., Giridhar R., Yadav M.R. 3D-QSAR studies of farnesyltransferase inhibitors: a comparative molecular field analysis approach. Bioorg. Med. Chem. Lett. 2006, 16:1821-1827.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 1821-1827
-
-
Puntambekar, D.S.1
Giridhar, R.2
Yadav, M.R.3
-
26
-
-
33750512720
-
Understanding the anti-tumor activity of novel tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors using CoMFA and CoMSIA
-
Puntambekar D.S., Giridhar R., Yadav M.R. Understanding the anti-tumor activity of novel tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors using CoMFA and CoMSIA. Eur. J. Med. Chem. 2006, 41:1279-1292.
-
(2006)
Eur. J. Med. Chem.
, vol.41
, pp. 1279-1292
-
-
Puntambekar, D.S.1
Giridhar, R.2
Yadav, M.R.3
-
27
-
-
38349000957
-
Insight into the structural requirements of farnesyltransferase inhibitors as potential anti-tumor agents based on 3D-QSAR CoMFA and CoMSIA models
-
Puntambekar D.S., Giridhar R., Yadav M.R. Insight into the structural requirements of farnesyltransferase inhibitors as potential anti-tumor agents based on 3D-QSAR CoMFA and CoMSIA models. Eur. J. Med. Chem. 2008, 43:142-154.
-
(2008)
Eur. J. Med. Chem.
, vol.43
, pp. 142-154
-
-
Puntambekar, D.S.1
Giridhar, R.2
Yadav, M.R.3
-
28
-
-
33645551958
-
3D-QSAR CoMFA/CoMSIA studies on 5-aryl 2-,2-dialkyl-4 phenyl-3 (2H)-furanone derivatives, as selective COX-2 inhibitors
-
Puntambekar D.S., Giridhar R., Yadav M.R. 3D-QSAR CoMFA/CoMSIA studies on 5-aryl 2-,2-dialkyl-4 phenyl-3 (2H)-furanone derivatives, as selective COX-2 inhibitors. Acta Pharm. 2006, 56:157-174.
-
(2006)
Acta Pharm.
, vol.56
, pp. 157-174
-
-
Puntambekar, D.S.1
Giridhar, R.2
Yadav, M.R.3
-
29
-
-
0027944195
-
Molecular similarity indices in a comparative analysis (CoMSIA) of drug molecules to correlate and predict their biological activity
-
Klebe G., Abraham U., Meitzner T. Molecular similarity indices in a comparative analysis (CoMSIA) of drug molecules to correlate and predict their biological activity. J. Med. Chem. 1994, 37:4130-4146.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 4130-4146
-
-
Klebe, G.1
Abraham, U.2
Meitzner, T.3
-
30
-
-
0023751431
-
Comparative molecular field analysis (CoMFA) Effect of shape on binding of steroids to carrier proteins
-
Cramer R., Patterson D., Bunce J. Comparative molecular field analysis (CoMFA) Effect of shape on binding of steroids to carrier proteins. J. Am. Chem. Soc. 1988, 110:5959-5967.
-
(1988)
J. Am. Chem. Soc.
, vol.110
, pp. 5959-5967
-
-
Cramer, R.1
Patterson, D.2
Bunce, J.3
-
31
-
-
77956280686
-
-
SYBYL 7.0, Tripos Inc. South Hanley Road, St. Louis, Missouri 63144, USA.
-
SYBYL 7.0, Tripos Inc., 1699 South Hanley Road, St. Louis, Missouri 63144, USA.
-
(1699)
-
-
-
33
-
-
0025390935
-
MOPAC: a semi impirical molecular orbital program
-
Stewart J. MOPAC: a semi impirical molecular orbital program. J. Comput. Aided Mol. Des. 1990, 4:1-105.
-
(1990)
J. Comput. Aided Mol. Des.
, vol.4
, pp. 1-105
-
-
Stewart, J.1
-
34
-
-
0842341771
-
Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model
-
Dewar M., Zoebisch E., Healy E., Stewart J. Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model. J. Am. Chem. Soc. 1985, 107:3902-3909.
-
(1985)
J. Am. Chem. Soc.
, vol.107
, pp. 3902-3909
-
-
Dewar, M.1
Zoebisch, E.2
Healy, E.3
Stewart, J.4
-
35
-
-
77956293570
-
-
CompuDrug, Latest Upgrades, (accessed February 10, 2010), .
-
CompuDrug, Latest Upgrades, (accessed February 10, 2010), http://www.compudrug.com/.
-
-
-
-
36
-
-
11944251068
-
Maximally diagonal force constants in dependent angle-bending co-ordinates. II. Implications for the design of empirical force fields
-
Halgren T.A. Maximally diagonal force constants in dependent angle-bending co-ordinates. II. Implications for the design of empirical force fields. J. Am. Chem. Soc. 1990, 112:4710-4723.
-
(1990)
J. Am. Chem. Soc.
, vol.112
, pp. 4710-4723
-
-
Halgren, T.A.1
-
37
-
-
0034089732
-
QSAR and CoMFA: a perspective on the practical application to drug discovery
-
Podlogar B.L., Fergusson D.M. QSAR and CoMFA: a perspective on the practical application to drug discovery. Drug Des. Discov. 2000, 17:4-12.
-
(2000)
Drug Des. Discov.
, vol.17
, pp. 4-12
-
-
Podlogar, B.L.1
Fergusson, D.M.2
-
38
-
-
28544441042
-
Cellular opoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study
-
Selassie C.D., Kapur S., Verma R.P., Rosario M. Cellular opoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study. J. Med. Chem. 2005, 48:7234-7242.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 7234-7242
-
-
Selassie, C.D.1
Kapur, S.2
Verma, R.P.3
Rosario, M.4
-
39
-
-
0038724207
-
The importance of being earnest: validation id the absolute essential for successful application and interpretation of QSAR model
-
Tropsha A., Gramatica P., Gombar V.K. The importance of being earnest: validation id the absolute essential for successful application and interpretation of QSAR model. QSAR Comb. Sci. 2003, 22:69-77.
-
(2003)
QSAR Comb. Sci.
, vol.22
, pp. 69-77
-
-
Tropsha, A.1
Gramatica, P.2
Gombar, V.K.3
-
41
-
-
28244451872
-
Inhibition of neutrophil elastase and thrombin activity by caffeic acid esters
-
Melzig M.F., Tran G.D., Henke K., Selassie C.D., Verma R.P. Inhibition of neutrophil elastase and thrombin activity by caffeic acid esters. Pharmazie 2005, 60:869-873.
-
(2005)
Pharmazie
, vol.60
, pp. 869-873
-
-
Melzig, M.F.1
Tran, G.D.2
Henke, K.3
Selassie, C.D.4
Verma, R.P.5
-
42
-
-
0024154259
-
Multivariate data analysis and experimental design in biomedical research
-
Stahle L., Wold S. Multivariate data analysis and experimental design in biomedical research. Prog. Med. Chem. 1988, 25:291-338.
-
(1988)
Prog. Med. Chem.
, vol.25
, pp. 291-338
-
-
Stahle, L.1
Wold, S.2
-
43
-
-
84987100711
-
Crossvalidation, bootstrapping, and partial least squares compared with multiple regression in conventional QSAR studies
-
Cramer R.D., Bunce J.D., Patterson D.E., Frank I.E. Crossvalidation, bootstrapping, and partial least squares compared with multiple regression in conventional QSAR studies. Quant. Struct. Act. Relat. 1988, 7:18-25.
-
(1988)
Quant. Struct. Act. Relat.
, vol.7
, pp. 18-25
-
-
Cramer, R.D.1
Bunce, J.D.2
Patterson, D.E.3
Frank, I.E.4
-
44
-
-
0027310371
-
Generating optimal linear PLS estimations (GOLPE): An advanced chemometric tool for handling 3D QSAR problems
-
Baroni M., Costantino G., Crucian G., Riganelli D., Valigi R., Clementi S. Generating optimal linear PLS estimations (GOLPE): An advanced chemometric tool for handling 3D QSAR problems. Quant. Struct. Act. Relat. 1993, 12:9-20.
-
(1993)
Quant. Struct. Act. Relat.
, vol.12
, pp. 9-20
-
-
Baroni, M.1
Costantino, G.2
Crucian, G.3
Riganelli, D.4
Valigi, R.5
Clementi, S.6
-
45
-
-
21144474350
-
Linear model selection by cross-validation
-
Shao J. Linear model selection by cross-validation. J. Am. Stat. Assoc. 1993, 88:486-494.
-
(1993)
J. Am. Stat. Assoc.
, vol.88
, pp. 486-494
-
-
Shao, J.1
|