-
1
-
-
12744253433
-
Modulation of p-glycoprotein transport function at the blood-brain barrier
-
2
-
Bauer B, Hartz AMS, Fricker G, Miller DS (2005) Modulation of p-glycoprotein transport function at the blood-brain barrier. Exp Biol Med 230(2):118-127
-
(2005)
Exp Biol Med
, vol.230
, pp. 118-127
-
-
Bauer, B.1
Hartz, A.M.S.2
Fricker, G.3
Miller, D.S.4
-
2
-
-
6944255523
-
Delivery of therapeutic agents to the central nervous system: The problems and the possibilities
-
1
-
Begley DJ (2004) Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. Pharmacol Ther 104(1):29-45
-
(2004)
Pharmacol Ther
, vol.104
, pp. 29-45
-
-
Begley, D.J.1
-
3
-
-
0026543285
-
Standardized kinetic microassay to quantify differential chemosensitivity on the basis of proliferative activity
-
1
-
Bernhardt G, Reile H, Birnböck H, Spruss T, Schönenberger H (1992) Standardized kinetic microassay to quantify differential chemosensitivity on the basis of proliferative activity. J Cancer Res Clin Oncol 118(1):35-41
-
(1992)
J Cancer Res Clin Oncol
, vol.118
, pp. 35-41
-
-
Bernhardt, G.1
Reile, H.2
Birnböck, H.3
Spruss, T.4
Schönenberger, H.5
-
4
-
-
0038582891
-
XR 9576 (tariquidar), a potent and specific p-glycoprotein inhibitor, has minimal effects on the pharmacokinetics of paclitaxel, doxorubicin, and vinorelbine and can be administered with full-dose chemotherapy in patients with cancer
-
(abstract 2173)
-
Boniface GR, Ferry DR, Atsmon J, Inbar M, van Tellingen O, Abraham J, Bates SE, Fajo AT, Thomas H, Mould G, Steiner J, Mellows G (2002) XR 9576 (tariquidar), a potent and specific p-glycoprotein inhibitor, has minimal effects on the pharmacokinetics of paclitaxel, doxorubicin, and vinorelbine and can be administered with full-dose chemotherapy in patients with cancer. Proc Am Soc Clin Oncol 21 (abstract 2173)
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
-
-
Boniface, G.R.1
Ferry, D.R.2
Atsmon, J.3
Inbar, M.4
Van Tellingen, O.5
Abraham, J.6
Bates, S.E.7
Fajo, A.T.8
Thomas, H.9
Mould, G.10
Steiner, J.11
Mellows, G.12
-
6
-
-
30344487254
-
Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs
-
1
-
Breedveld P, Beijnen JH, Schellens JHM (2006) Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs. Trends Pharmacol Sci 27(1):17-24
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 17-24
-
-
Breedveld, P.1
Beijnen, J.H.2
Schellens, J.H.M.3
-
7
-
-
0029011403
-
Synthesis and activity against multidrug resistance in Chinese hamster ovary cells of new acridone-4-carboxamides.
-
13
-
Dodic N, Dumaitre B, Daugan A, Pianetti P (1995) Synthesis and activity against multidrug resistance in Chinese hamster ovary cells of new acridone-4-carboxamides. J Med Chem 38(13):2418-2426
-
(1995)
J Med Chem
, vol.38
, pp. 2418-2426
-
-
Dodic, N.1
Dumaitre, B.2
Daugan, A.3
Pianetti, P.4
-
8
-
-
0035984821
-
GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats
-
7
-
Edwards JE, Brouwer KR, McNamara PJ (2002) GF120918, a P-glycoprotein modulator, increases the concentration of unbound amprenavir in the central nervous system in rats. Antimicrob Agents Chemother 46(7):2284-2286
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 2284-2286
-
-
Edwards, J.E.1
Brouwer, K.R.2
McNamara, P.J.3
-
9
-
-
34250626127
-
Tariquidar analogues: Synthesis by Cu(I)-catalysed N/O-aryl coupling and inhibitory activity against the ABCB1 transporter
-
Egger M, Li X, Müller C, Bernhardt G, Buschauer A, König B (2007) Tariquidar analogues: synthesis by Cu(I)-catalysed N/O-aryl coupling and inhibitory activity against the ABCB1 transporter. Eur J Org Chem (16):2643-2649
-
(2007)
Eur J Org Chem
, vol.16
, pp. 2643-2649
-
-
Egger, M.1
Li, X.2
Müller, C.3
Bernhardt, G.4
Buschauer, A.5
König, B.6
-
11
-
-
0036841686
-
Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo
-
9
-
Fellner S, Bauer B, Miller DS, Schaffrik M, Fankhänel M, Spruss T, Bernhardt G, Gräff C, Färber L, Gschaidmeier H, Buschauer A, Fricker G (2002) Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest 110(9):1309-1318
-
(2002)
J Clin Invest
, vol.110
, pp. 1309-1318
-
-
Fellner, S.1
Bauer, B.2
Miller, D.S.3
Schaffrik, M.4
Fankhänel, M.5
Spruss, T.6
Bernhardt, G.7
Gräff, C.8
Färber, L.9
Gschaidmeier, H.10
Buschauer, A.11
Fricker, G.12
-
12
-
-
0345084436
-
The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3A. Implications for drug-drug interactions and pharmacological activity of the main metabolite
-
8
-
Fischer V, Rodriguez-Gascon A, Heitz F, Tynes R, Hauck C, Cohen D, Vickers AEM (1998) The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3A. Implications for drug-drug interactions and pharmacological activity of the main metabolite. Drug Metab Dispos 26(8):802-811
-
(1998)
Drug Metab Dispos
, vol.26
, pp. 802-811
-
-
Fischer, V.1
Rodriguez-Gascon, A.2
Heitz, F.3
Tynes, R.4
Hauck, C.5
Cohen, D.6
Vickers, A.E.M.7
-
13
-
-
1542313853
-
Modulation of drug transporters at the blood-brain barrier
-
4
-
Fricker G, Miller DS (2004) Modulation of drug transporters at the blood-brain barrier. Pharmacology 70(4):169-176
-
(2004)
Pharmacology
, vol.70
, pp. 169-176
-
-
Fricker, G.1
Miller, D.S.2
-
14
-
-
3242785620
-
Importance of P-glycoprotein at blood-tissue barriers
-
8
-
Fromm MF (2004) Importance of P-glycoprotein at blood-tissue barriers. Trends Pharmacol Sci 25(8):423-429
-
(2004)
Trends Pharmacol Sci
, vol.25
, pp. 423-429
-
-
Fromm, M.F.1
-
15
-
-
0032958648
-
The role of paclitaxel in the treatment of primary and metastatic brain tumors
-
2 Suppl 1
-
Glantz MJ, Chamberlain MC, Chang SM, Prados MD, Cole BF (1999) The role of paclitaxel in the treatment of primary and metastatic brain tumors. Semin Radiat Oncol 9(2 Suppl 1):27-33
-
(1999)
Semin Radiat Oncol
, vol.9
, pp. 27-33
-
-
Glantz, M.J.1
Chamberlain, M.C.2
Chang, S.M.3
Prados, M.D.4
Cole, B.F.5
-
16
-
-
0027432409
-
Fluorescent cellular indicators are extruded by the multidrug resistance protein
-
29
-
Homolya L, Hollo Z, Germann U, Pastan I, Gottesman M, Sarkadi B (1993) Fluorescent cellular indicators are extruded by the multidrug resistance protein. J Biol Chem 268(29):21493-21496
-
(1993)
J Biol Chem
, vol.268
, pp. 21493-21496
-
-
Homolya, L.1
Hollo, Z.2
Germann, U.3
Pastan, I.4
Gottesman, M.5
Sarkadi, B.6
-
18
-
-
0037307995
-
Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir
-
2
-
Huisman MT, Smit JW, Wiltshire HR, Beijnen JH, Schinkel AH (2003) Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir. J Pharmacol Exp Ther 304(2):596-602
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 596-602
-
-
Huisman, M.T.1
Smit, J.W.2
Wiltshire, H.R.3
Beijnen, J.H.4
Schinkel, A.H.5
-
19
-
-
0027524642
-
In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative
-
19
-
Hyafil F, Vergely C, Du Vignaud P., Grand-Perret T (1993) In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Cancer Res 53(19):4595-4602
-
(1993)
Cancer Res
, vol.53
, pp. 4595-4602
-
-
Hyafil, F.1
Vergely, C.2
Du Vignaud, P.3
Grand-Perret, T.4
-
20
-
-
0037478891
-
Increased penetration of paclitaxel into the brain by inhibition of P-glycoprotein
-
7
-
Kemper EM, van Zandbergen AE, Cleypool C, Mos HA, Boogerd W, Beijnen JH, van Tellingen O (2003) Increased penetration of paclitaxel into the brain by inhibition of P-glycoprotein. Clin Cancer Res 9(7):2849-2855
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2849-2855
-
-
Kemper, E.M.1
Van Zandbergen, A.E.2
Cleypool, C.3
Mos, H.A.4
Boogerd, W.5
Beijnen, J.H.6
Van Tellingen, O.7
-
21
-
-
1942424048
-
Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein
-
8
-
Kemper EMVM, Boogerd W, Beijnen JH, Van Tellingen O (2004) Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein. Eur J Cancer 40(8):1269-1274
-
(2004)
Eur J Cancer
, vol.40
, pp. 1269-1274
-
-
Emvm, K.1
Boogerd, W.2
Beijnen, J.H.3
Van Tellingen, O.4
-
22
-
-
0024151766
-
Vincristine-resistant human cancer KB cell line and increased expression of multidrug-resistance gene
-
11
-
Kohno K, Kikuchi J, Sato S, Takano H, Saburi Y, Asoh K, Kuwano M (1988) Vincristine-resistant human cancer KB cell line and increased expression of multidrug-resistance gene. Jpn J Cancer Res 79(11):1238-1246
-
(1988)
Jpn J Cancer Res
, vol.79
, pp. 1238-1246
-
-
Kohno, K.1
Kikuchi, J.2
Sato, S.3
Takano, H.4
Saburi, Y.5
Asoh, K.6
Kuwano, M.7
-
23
-
-
0036644903
-
Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918
-
13
-
Kruijtzer CMF, Beijnen JH, Rosing H, ten Bokkel Huinink WW, Schot M, Jewell RC, Paul EM, Schellens JHM (2002) Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918. J Clin Oncol 20(13):2943-2950
-
(2002)
J Clin Oncol
, vol.20
, pp. 2943-2950
-
-
Kruijtzer, C.M.F.1
Beijnen, J.H.2
Rosing, H.3
Ten Bokkel Huinink, W.W.4
Schot, M.5
Jewell, R.C.6
Paul, E.M.7
Schellens, J.H.M.8
-
24
-
-
33748051705
-
The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity
-
3
-
Kurnik D, Wood AJJ, Wilkinson GR (2006) The erythromycin breath test reflects P-glycoprotein function independently of cytochrome P450 3A activity. Clin Pharmacol Ther 80(3):228-234
-
(2006)
Clin Pharmacol Ther
, vol.80
, pp. 228-234
-
-
Kurnik, D.1
Wood, A.J.J.2
Wilkinson, G.R.3
-
25
-
-
34247543067
-
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2)
-
11
-
Labrie P, Maddaford SP, Lacroix J, Catalano C, Lee DK, Rakhit S, Gaudreault RC (2007) In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2). Bioorg Med Chem 15(11):3854-3868
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 3854-3868
-
-
Labrie, P.1
Maddaford, S.P.2
Lacroix, J.3
Catalano, C.4
Lee, D.K.5
Rakhit, S.6
Gaudreault, R.C.7
-
26
-
-
0031946026
-
Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat
-
4
-
Letrent SPPGM, Brouwer KR, Brouwer KL (1998) Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat. Pharm Res 15(4):599-605
-
(1998)
Pharm Res
, vol.15
, pp. 599-605
-
-
Sppgm, L.1
Brouwer, K.R.2
Brouwer, K.L.3
-
27
-
-
23044500398
-
Drug resistance in brain diseases and the role of drug efflux transporters
-
8
-
Löscher W, Potschka H (2005) Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci 6(8):591-602
-
(2005)
Nat Rev Neurosci
, vol.6
, pp. 591-602
-
-
Löscher, W.1
Potschka, H.2
-
28
-
-
0035863315
-
In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576
-
2
-
Mistry P, Stewart AJ, Dangerfield W, Okiji S, Liddle C, Bootle D, Plumb JA, Templeton D, Charlton P (2001) In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576. Cancer Res 61(2):749-758
-
(2001)
Cancer Res
, vol.61
, pp. 749-758
-
-
Mistry, P.1
Stewart, A.J.2
Dangerfield, W.3
Okiji, S.4
Liddle, C.5
Bootle, D.6
Plumb, J.A.7
Templeton, D.8
Charlton, P.9
-
29
-
-
33845352935
-
Inhibitors of kinesin Eg5: Antiproliferative activity of monastrol analogues against human glioblastoma cells
-
2
-
Müller C, Gross D, Sarli V, Gartner M, Giannis A, Bernhardt G, Buschauer A (2007) Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells. Cancer Chemother Pharmacol 59(2):157-164
-
(2007)
Cancer Chemother Pharmacol
, vol.59
, pp. 157-164
-
-
Müller, C.1
Gross, D.2
Sarli, V.3
Gartner, M.4
Giannis, A.5
Bernhardt, G.6
Buschauer, A.7
-
30
-
-
0033593855
-
Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives
-
4
-
Roe M, Folkes A, Ashworth P, Brumwell J, Chima L, Hunjan S, Pretswell I, Dangerfield W, Ryder H, Charlton P (1999) Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives. Bioorg Med Chem Lett 9(4):595-600
-
(1999)
Bioorg Med Chem Lett
, vol.9
, pp. 595-600
-
-
Roe, M.1
Folkes, A.2
Ashworth, P.3
Brumwell, J.4
Chima, L.5
Hunjan, S.6
Pretswell, I.7
Dangerfield, W.8
Ryder, H.9
Charlton, P.10
-
31
-
-
0036627481
-
Drug delivery to brain via the blood-brain barrier
-
6
-
Scherrmann JM (2002) Drug delivery to brain via the blood-brain barrier. Vasc Pharmacol 38(6):349-354
-
(2002)
Vasc Pharmacol
, vol.38
, pp. 349-354
-
-
Scherrmann, J.M.1
-
32
-
-
0037464458
-
Comparison of in vitro P-glycoprotein screening assays: Recommendations for their use in drug discovery
-
9
-
Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J (2003) Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem 46(9):1716-1725
-
(2003)
J Med Chem
, vol.46
, pp. 1716-1725
-
-
Schwab, D.1
Fischer, H.2
Tabatabaei, A.3
Poli, S.4
Huwyler, J.5
-
33
-
-
41049108170
-
Synthesis of acridine derivative as multidrug-resistant inhibitor
-
Patent WO 98-EP2991 19980522
-
Sharp MJ, Mader CJ, Strachan C (1998) Synthesis of acridine derivative as multidrug-resistant inhibitor. Patent WO 98-EP2991 19980522
-
(1998)
-
-
Sharp, M.J.1
Mader, C.J.2
Strachan, C.3
-
34
-
-
0028943730
-
Determination of paclitaxel and metabolites in mouse plasma, tissues, urine and faeces by semi-automated reversed-phase high-performance liquid chromatography
-
2
-
Sparreboom A, van Tellingen O, Nooijwn WJ, Beijnen JH (1995) Determination of paclitaxel and metabolites in mouse plasma, tissues, urine and faeces by semi-automated reversed-phase high-performance liquid chromatography. J Chromatogr B Biomed Appl 664(2):383-391
-
(1995)
J Chromatogr B Biomed Appl
, vol.664
, pp. 383-391
-
-
Sparreboom, A.1
Van Tellingen, O.2
Nooijwn, W.J.3
Beijnen, J.H.4
-
35
-
-
12644278301
-
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
-
5
-
Sparreboom A, van Asperen J, Mayer U, Schinkel AH, Smit JW, Meijer DKF, Borst P, Nooijen WJ, Beijnen JH, van Tellingen O (1997) Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sci USA 94(5):2031-2035
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2031-2035
-
-
Sparreboom, A.1
Van Asperen, J.2
Mayer, U.3
Schinkel, A.H.4
Smit, J.W.5
Meijer, D.K.F.6
Borst, P.7
Nooijen, W.J.8
Beijnen, J.H.9
Van Tellingen, O.10
-
36
-
-
0033390989
-
Clinical pharmacokinetics of doxorubicin in combination with GF120918, a potent inhibitor of MDR1 P-glycoprotein
-
8
-
Sparreboom A, Planting AST, Jewell RC, Van der Burg MEL, Van der Gaast A, De Bruijn P, Loos WJ, Nooter K, Chandler LH, Paul EM, Wissel PS, Verweij J (1999) Clinical pharmacokinetics of doxorubicin in combination with GF120918, a potent inhibitor of MDR1 P-glycoprotein. Anticancer Drugs 10(8):719-728
-
(1999)
Anticancer Drugs
, vol.10
, pp. 719-728
-
-
Sparreboom, A.1
Planting, A.S.T.2
Jewell, R.C.3
Van Der Burg, M.E.L.4
Van Der Gaast, A.5
De Bruijn, P.6
Loos, W.J.7
Nooter, K.8
Chandler, L.H.9
Paul, E.M.10
Wissel, P.S.11
Verweij, J.12
-
37
-
-
0033740397
-
Phase I trial of XR9576 in healthy volunteers demonstrates modulation of P-glycoprotein in CD56+ lymphocytes after oral and intravenous administration
-
11
-
Stewart A, Steiner J, Mellows G, Laguda B, Norris D, Bevan P (2000) Phase I trial of XR9576 in healthy volunteers demonstrates modulation of P-glycoprotein in CD56+ lymphocytes after oral and intravenous administration. Clin Cancer Res 6(11):4186-4191
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4186-4191
-
-
Stewart, A.1
Steiner, J.2
Mellows, G.3
Laguda, B.4
Norris, D.5
Bevan, P.6
-
38
-
-
33644775686
-
Targeting multidrug resistance in cancer
-
3
-
Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM (2006) Targeting multidrug resistance in cancer. Nat Rev Drug Discov 5(3):219-234
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 219-234
-
-
Szakacs, G.1
Paterson, J.K.2
Ludwig, J.A.3
Booth-Genthe, C.4
Gottesman, M.M.5
-
39
-
-
0037358040
-
Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting p-glycoprotein
-
2
-
Thomas H, Coley HM (2003) Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 10(2):159-165
-
(2003)
Cancer Control
, vol.10
, pp. 159-165
-
-
Thomas, H.1
Coley, H.M.2
-
40
-
-
18044376796
-
Multidrug resistance proteins (MRPs) and implication in drug development
-
1
-
Tian Q, Zhang J, Chan E, Duan W, Zhou S (2005) Multidrug resistance proteins (MRPs) and implication in drug development. Drug Dev Res 64(1):1-18
-
(2005)
Drug Dev Res
, vol.64
, pp. 1-18
-
-
Tian, Q.1
Zhang, J.2
Chan, E.3
Duan, W.4
Zhou, S.5
-
41
-
-
0030613634
-
Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833
-
9
-
van Asperen J, van Tellingen O, Sparreboom A, Schinkel AH, Borst P, Nooijen WJ, Beijnen JH (1997) Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. Br J Cancer 76(9):1181-1183
-
(1997)
Br J Cancer
, vol.76
, pp. 1181-1183
-
-
Van Asperen, J.1
Van Tellingen, O.2
Sparreboom, A.3
Schinkel, A.H.4
Borst, P.5
Nooijen, W.J.6
Beijnen, J.H.7
-
42
-
-
0345411341
-
P-Glycoprotein and cytochrome P-450 3A inhibition: Dissociation of inhibitory potencies.
-
16
-
Wandel C, Kim RB, Kajiji S, Guengerich FP, Wilkinson GR, Wood AJ (1999) P-Glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies. Cancer Res 59(16):3944-3948
-
(1999)
Cancer Res
, vol.59
, pp. 3944-3948
-
-
Wandel, C.1
Kim, R.B.2
Kajiji, S.3
Guengerich, F.P.4
Wilkinson, G.R.5
Wood, A.J.6
-
43
-
-
3343001907
-
Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A (HCl salt of GF120918, 9,10-dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4- tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the mouse, rat, dog, and monkey.
-
2
-
Ward KW, Azzarano LM (2004) Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A (HCl salt of GF120918, 9,10-dihydro-5- methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl] phenyl]-4-acridine-carboxamide) in the mouse, rat, dog, and monkey. J Pharmacol Exp Ther 310(2):703-709
-
(2004)
J Pharmacol Exp Ther
, vol.310
, pp. 703-709
-
-
Ward, K.W.1
Azzarano, L.M.2
|