Aldosterone production and insulin resistance in healthy adults

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 4, 2010, Pages 1986-1990

  Garg, Rajesh ^a   Hurwitz, Shelley ^a   Williams, Gordon H ^a   Hopkins, Paul N ^b   Adler, Gail K ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; GLUCOSE; HYDROCORTISONE; INSULIN;

ADULT; AGED; ALDOSTERONE BLOOD LEVEL; ALDOSTERONE URINE LEVEL; ARTICLE; BLOOD SAMPLING; BODY MASS; DIASTOLIC BLOOD PRESSURE; FEMALE; GLUCOSE BLOOD LEVEL; HIGH SODIUM INTAKE; HUMAN; HYDROCORTISONE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; SODIUM URINE LEVEL; SYSTOLIC BLOOD PRESSURE; ADOLESCENT; AGING; BIOSYNTHESIS; BLOOD PRESSURE; MIDDLE AGED; PHYSIOLOGY; PREDICTION AND FORECASTING; REFERENCE VALUE; SEXUAL DEVELOPMENT; STIMULATION;

ADOLESCENT; ADULT; AGED; AGING; ALDOSTERONE; ANGIOTENSIN II; BLOOD PRESSURE; BODY MASS INDEX; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; REFERENCE VALUES; SEX CHARACTERISTICS; STIMULATION, CHEMICAL; YOUNG ADULT;

EID: 77951649148     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2521     Document Type: Article

References (20)

1. Catena C, Lapenna R, Baroselli S, Nadalini E, Colussi G, Novello M, Favret G, Melis A, Cavarape A, Sechi LA 2006 Insulin sensitivity in patients with primary aldosteronism: a follow-up study. J Clin Endocrinol Metab 91:3457-3463
2. Rossi GP, Belfiore A, Bernini G, Fabris B, Caridi G, Ferri C, Giacchetti G, Letizia C, Maccario M, Mannelli M, Palumbo G, Patalano A, Rizzoni D, Rossi E, Pessina AC, Mantero F 2008 Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertensive patients. J Clin Endocrinol Metab 93:2566-2571
3. Colussi G, Catena C, Lapenna R, Nadalini E, Chiuch A, Sechi LA 2007 Insulin resistance and hyperinsulinemia are related to plasma aldosterone levels in hypertensive patients. Diabetes Care 30:2349-2354
4. Bentley-Lewis R, Adler GK, Perlstein T, Seely EW, Hopkins PN, Williams GH, Garg R 2007 Body mass index predicts aldosterone production in normotensive adults on a high-salt diet. J Clin Endocrinol Metab 92:4472-4475 (Pubitemid 350074772)
5. García-Estévez DA, Araújo-Vilar D, Fiestras-Janeiro G, Saavedra-González A, Cabezas-Cerrato J 2003 Comparison of several insulin sensitivity indices derived from basal plasma insulin and glucose levels with minimal model indices. Horm Metab Res 35:13-17
6. Matsuda M, DeFronzo RA 1999 Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462-1470
7. Dluhy RG 1978 Adrenal function testing. Compr Ther 4:53-59
8. Kosachunhanun N, Hunt SC, Hopkins PN, Williams RR, Jeunemaitre X, Corvol P, Ferri C, Mortensen RM, Hollenberg NK, Williams GH 2003 Genetic determinants of nonmodulating hypertension. Hypertension 42:901-908
9. Pojoga L, Kolatkar NS, Williams JS, Perlstein TS, Jeunemaitre X, Brown NJ, Hopkins PN, Raby BA, Williams GH 2006 β2 Adrenergic receptor diplotype defines a subset of salt-sensitive hypertension. Hypertension 48:892-900
10. Williams JS, Williams GH, Raji A, Jeunemaitre X, Brown NJ, Hopkins PN, Conlin PR 2006 Prevalence of primary hyperaldosteronism in mild to moderate hypertension without hypokalaemia. J Hum Hypertens 20:129-136
11. Gonzaga CC, Calhoun DA 2008 Resistant hypertension and hyperaldosteronism. Curr Hypertens Rep 10:496-503
12. Rocchini AP, Katch VL, Grekin R, Moorehead C, Anderson J 1986 Role for aldosterone in blood pressure regulation of obese adolescents. Am J Cardiol 57:613-618
13. Dall'Asta C, Vedani P, Manunta P, Pizzocri P, Marchi M, Paganelli M, Folli F, Pontiroli AE 2009 Effect of weight loss through laparoscopic gastric banding on blood pressure, plasma renin activity and aldosterone levels in morbid obesity. Nutr Metab Cardiovasc Dis 19:110-114
14. Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, Langenbach J, Willenberg HS, Barthel A, Hauner H, McCann SM, Scherbaum WA, Bornstein SR 2003 Human adipocytes secrete mineralocorticoid-releasing factors. Proc Natl Acad Sci USA 100:14211-14216
15. Ehrhart-Bornstein M, Arakelyan K, Krug AW, Scherbaum WA, Bornstein SR 2004 Fat cells may be the obesity-hypertension link: human adipogenic factors stimulate aldosterone secretion from adrenocortical cells. Endocr Res 30:865-870 (Pubitemid 40070185)
16. Goodfriend TL, Kelley DE, Goodpaster BH, Winters SJ 1999 Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women. Obes Res 7:355-362
17. Wada T, Ohshima S, Fujisawa E, Koya D, Tsuneki H, Sasaoka T 2009 Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes. Endocrinology 150:1662-1669
18. Guo C, Ricchiuti V, Lian BQ, Yao TM, Coutinho P, Romero JR, Li J, Williams GH, Adler GK 2008 Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-γ, and proinflammatory adipokines. Circulation 117:2253-2261
19. Hirata A, Maeda N, Hiuge A, Hibuse T, Fujita K, Okada T, Kihara S, Funahashi T, Shimomura I 2009 Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice. Cardiovasc Res 84:164-172
20. Sowers JR, Whaley-Connell A, Epstein M 2009 Narrative review: the emerging clinical implications of the role of aldosterone in the metabolic syndrome and resistant hypertension. Ann Intern Med 150:776-783