Enantioselective determination of doxazosin in human plasma by liquid chromatography-tandem mass spectrometry using ovomucoid chiral stationary phase

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 26, 2010, Pages 2415-2420

  Liu, Ke ^a   Zhong, Dafang ^a   Chen, Xiaoyan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Doxazosin; Enantiomers; Enantioselective LC MS MS; Stereoselective pharmacokinetics

Indexed keywords

ALKALINE CONDITIONS; CHIRAL INVERSION; CHIRAL SEPARATIONS; CHIRAL STATIONARY PHASE; CONCENTRATION RANGES; DOXAZOSIN; ENANTIOSELECTIVE; HUMAN PLASMAS; INTER-ASSAY PRECISION; INTERNAL STANDARDS; ISOCRATIC MOBILE PHASE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; MASS SPECTROMETRIC DATA; MULTIPLE-REACTION MONITORING MODES; ORAL ADMINISTRATION; OVOMUCOID; PHARMACOKINETIC STUDIES; SENSITIVE METHOD; STEREO-SELECTIVE; THERAPEUTIC DOSE;

AMMONIUM COMPOUNDS; ENANTIOMERS; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); PLASMAS; STEREOSELECTIVITY;

CHIRALITY;

DOXAZOSIN; PRAZOSIN;

ACCURACY; ADULT; ARTICLE; CHIRALITY; ENANTIOSELECTIVITY; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; RACEMIC MIXTURE; TANDEM MASS SPECTROMETRY;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; CHROMATOGRAPHY, LIQUID; DOXAZOSIN; DRUG STABILITY; HUMANS; LEAST-SQUARES ANALYSIS; OVOMUCIN; PRAZOSIN; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

EID: 77956264876     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.07.027     Document Type: Article

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