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Volumn 69, Issue 8, 2009, Pages 895-907

A broader role for 5ARIs in prostate disease? Existing evidence and emerging benefits

Author keywords

Benign prostatic enlargement; Benign prostatic hyperplasia; Dutasteride; Finasteride; Prostate cancer

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANDROSTANOLONE; ANTIANDROGEN; BICALUTAMIDE; DOXAZOSIN; DUTASTERIDE; FINASTERIDE; GONADORELIN AGONIST; KETOCONAZOLE; PLACEBO; PROSTATE SPECIFIC ANTIGEN; STEROID 5ALPHA REDUCTASE INHIBITOR; TAMSULOSIN; AZASTEROID; ENZYME INHIBITOR; STEROID 5ALPHA REDUCTASE; SULFONAMIDE; TESTOSTERONE;

EID: 65549152762     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.20939     Document Type: Article
Times cited : (16)

References (75)
  • 1
    • 0037377691 scopus 로고    scopus 로고
    • The role of dihydrotestosterone in benign prostatic hyperplasia
    • DOI 10.1016/S0090-4295(03)00045-1
    • Carson C III, , Rittmaster R. The role of dihydrotestosterone in benign prostatic hyperplasia. Urology 2003;61:2-7. (Pubitemid 36349123)
    • (2003) Urology , vol.61 , Issue.4 SUPPL. 1 , pp. 2-7
    • Carson III, C.1    Rittmaster, R.2
  • 2
    • 0025037581 scopus 로고
    • Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone
    • Grino PB, Griffin JE, Wilson JD. Testosterone at high concentrations interacts with the human androgen receptor similarly to dihydrotestosterone. Endocrinology 1990;126:1165-1172. (Pubitemid 20079537)
    • (1990) Endocrinology , vol.126 , Issue.2 , pp. 1165-1172
    • Grino, P.B.1    Griffin, J.E.2    Wilson, J.D.3
  • 4
    • 0033305674 scopus 로고    scopus 로고
    • Androgen-induced regrowth in the castrated rat ventral prostate: Role of 5alpha-reductase
    • Wright AS, Douglas RC, Thomas LN, Lazier CB, Rittmaster RS. Androgen-induced regrowth in the castrated rat ventral prostate: Role of 5alpha-reductase. Endocrinology 1999;140:4509-4515.
    • (1999) Endocrinology , vol.140 , pp. 4509-4515
    • Wright, A.S.1    Douglas, R.C.2    Thomas, L.N.3    Lazier, C.B.4    Rittmaster, R.S.5
  • 6
    • 17644362707 scopus 로고    scopus 로고
    • Differential alterations in 5α-reductase type 1 and type 2 levels during development and progression of prostate cancer
    • DOI 10.1002/pros.20188
    • Thomas LN, Lazier CB, Gupta R, Norman RW, Troyer DA, OBrien SP, Rittmaster RS. Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer. Prostate 2005;63:231-239. (Pubitemid 40571057)
    • (2005) Prostate , vol.63 , Issue.3 , pp. 231-239
    • Thomas, L.N.1    Lazier, C.B.2    Gupta, R.3    Norman, R.W.4    Troyer, D.A.5    O'Brien, S.P.6    Rittmaster, R.S.7
  • 8
    • 36749022314 scopus 로고    scopus 로고
    • Levels of 5α-Reductase Type 1 and Type 2 are Increased in Localized High Grade Compared to Low Grade Prostate Cancer
    • DOI 10.1016/j.juro.2007.08.155, PII S002253470702335X
    • Thomas LN, Douglas RC, Lazier CB, Gupta R, Norman RW, Murphy PR, Rittmaster RS, Too CK. Levels of 5alpha-reductase type 1 and type 2 are increased in localized high grade compared to low grade prostate cancer. J Urol 2008;179:147-151. (Pubitemid 350216746)
    • (2008) Journal of Urology , vol.179 , Issue.1 , pp. 147-151
    • Thomas, L.N.1    Douglas, R.C.2    Lazier, C.B.3    Gupta, R.4    Norman, R.W.5    Murphy, P.R.6    Rittmaster, R.S.7    Too, C.K.L.8
  • 9
    • 42949126233 scopus 로고    scopus 로고
    • Biochemical and pharmacoligical evidence for a third isozyme of steroid 5a-reductase in prostate cancer
    • Abstract # 268
    • Titus M, Li Y, Kawinski E, Kozyreva O, Mohler JL. Biochemical and pharmacoligical evidence for a third isozyme of steroid 5a-reductase in prostate cancer. J Urol 2007;177(4Suppl): Abstract # 268.
    • (2007) J Urol , vol.177 , Issue.4 SUPPL.
    • Titus, M.1    Li, Y.2    Kawinski, E.3    Kozyreva, O.4    Mohler, J.L.5
  • 10
    • 36949000088 scopus 로고    scopus 로고
    • Novel 5α-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer
    • DOI 10.1111/j.1349-7006.2007.00656.x
    • Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, Nakagawa H. Novel 5 alpha-steroid reductase (SRD5A3, type 3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci 2008;99:81-86. (Pubitemid 350239034)
    • (2008) Cancer Science , vol.99 , Issue.1 , pp. 81-86
    • Uemura, M.1    Tamura, K.2    Chung, S.3    Honma, S.4    Okuyama, A.5    Nakamura, Y.6    Nakagawa, H.7
  • 12
    • 0025808821 scopus 로고
    • Pharmacokinetics and biochemical efficacy after single and multiple oral administration of N-(2-methyl-2-propyl)-3-oxo-4-aza-5 alpha-androst-1-ene-17 beta-carboxamide, a new type of specific competitive inhibitor of testosterone 5 alpha-reductase, in volunteers
    • Ohtawa M, Morikawa H, Shimazaki J. Pharmacokinetics and biochemical efficacy after single and multiple oral administration of N-(2-methyl-2-propyl)- 3-oxo-4-aza-5 alpha-androst-1-ene-17 beta-carboxamide, a new type of specific competitive inhibitor of testosterone 5 alpha-reductase, in volunteers. Eur J Drug Metab Pharmacokinet 1991;16:15-21.
    • (1991) Eur J Drug Metab Pharmacokinet , vol.16 , pp. 15-21
    • Ohtawa, M.1    Morikawa, H.2    Shimazaki, J.3
  • 13
    • 0028807269 scopus 로고
    • Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: Towards perfection of rates of time-dependent inhibition by using ligand-binding energies
    • Tian G, Mook RA Jr., Moss ML, Frye SV. Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: Towards perfection of rates of time-dependent inhibition by using ligand-binding energies. Biochemistry 1995;34: 13453-13459.
    • (1995) Biochemistry , vol.34 , pp. 13453-13459
    • Tian, G.1    Mook Jr., R.A.2    Moss, M.L.3    Frye, S.V.4
  • 16
    • 0026503988 scopus 로고
    • Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia
    • McConnell JD, Wilson JD, George FW, Geller J, Pappas F, Stoner E. Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. J Clin Endocrinol Metab 1992;74:505-508.
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 505-508
    • McConnell, J.D.1    Wilson, J.D.2    George, F.W.3    Geller, J.4    Pappas, F.5    Stoner, E.6
  • 17
    • 0345672747 scopus 로고    scopus 로고
    • Selectivity of finasteride as an in vivo inhibitor of 5α-reductase isozyme enzymatic activity in the human prostate
    • DOI 10.1016/S0022-5347(01)62141-4
    • Span PN, Voller MC, Smals AG, Sweep FG, Schalken JA, Feneley MR, Kirby RS. Selectivity of finasteride as an in vivo inhibitor of 5alpha-reductase isozyme enzymatic activity in the human prostate. J Urol 1999;161:332-337. (Pubitemid 29422357)
    • (1999) Journal of Urology , vol.161 , Issue.1 , pp. 332-337
    • Span, P.N.1    Voller, M.C.W.2    Smals, A.G.H.3    Sweep, F.G.J.4    Schalken, J.A.5    Feneley, M.R.6    Kirby, R.S.7
  • 19
    • 34249989027 scopus 로고    scopus 로고
    • The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia
    • DOI 10.1038/sj.pcan.4500931, PII 4500931
    • Wurzel R, Ray P, Major-Walker K, Shannon J, Rittmaster R. The effect of dutasteride on intraprostatic dihydrotestosterone concentration in men with benign prostatic hyperplasia. Prostate Cancer Prostatic Dis 2007;10:149-154. (Pubitemid 46881666)
    • (2007) Prostate Cancer and Prostatic Diseases , vol.10 , Issue.2 , pp. 149-154
    • Wurzel, R.1    Ray, P.2    Major-Walker, K.3    Shannon, J.4    Rittmaster, R.5
  • 20
    • 33750486196 scopus 로고    scopus 로고
    • The effects of the dual 5α-reductase inhibitor dutasteride on localized prostate cancer - Results from a 4-month pre-radical prostatectomy study
    • DOI 10.1002/pros.20499
    • Gleave M, Qian J, Andreou C, Pommerville P, Chin J, Casey R, Steinhoff G, Fleshner N, Bostwick D, Thomas L, Rittmaster R. The effects of the dual 5alpha-reductase inhibitor dutasteride on localized prostate cancer-results from a 4-month pre-radical prostatectomy study. Prostate 2006;66:1674-1685. (Pubitemid 44646358)
    • (2006) Prostate , vol.66 , Issue.15 , pp. 1674-1685
    • Gleave, M.1    Qian, J.2    Andreou, C.3    Pommerville, P.4    Chin, J.5    Casey, R.6    Steinhoff, G.7    Fleshner, N.8    Bostwick, D.9    Thomas, L.10    Rittmaster, R.11
  • 21
    • 5144229259 scopus 로고    scopus 로고
    • EAU 2004 guidelines on assessment, therapy and follow-up of men with lower urinary tract symptoms suggestive of benign prostatic obstruction (BPH guidelines)
    • DOI 10.1016/j.eururo.2004.07.016, PII S0302283804003562
    • Madersbacher S, Alivizatos G, Nordling J, Rioja Sanz C, Emberton M, de la Rosette JJ. EAU 2004 guidelines on assessment, therapy and follow-up of men with lower urinary tract symptoms suggestive of benign prostatic obstruction (BPHguidelines). Eur Urol 2004;46:547-554. (Pubitemid 39345720)
    • (2004) European Urology , vol.46 , Issue.5 , pp. 547-554
    • Madersbacher, S.1    Alivizatos, G.2    Nordling, J.3    Sanz, C.R.4    Emberton, M.5    De La Rosette, J.J.M.C.H.6
  • 22
    • 0035049190 scopus 로고    scopus 로고
    • The progression of benign prostatic hyperplasia: Examining the evidence and determining the risk
    • Anderson JB, Roehrborn CG, Schalken JA, Emberton M. The progression of benign prostatic hyperplasia: Examining the evidence and determining the risk. Eur Urol 2001;39:390-399.
    • (2001) Eur Urol , vol.39 , pp. 390-399
    • Anderson, J.B.1    Roehrborn, C.G.2    Schalken, J.A.3    Emberton, M.4
  • 23
    • 0033104455 scopus 로고    scopus 로고
    • Serum prostate-specific antigen as a predictor of prostate volume in men with benign prostatic hyperplasia
    • DOI 10.1016/S0090-4295(98)00655-4, PII S0090429598006554
    • Roehrborn CG, Boyle P, Gould AL, Waldstreicher J. Serum prostate-specific antigen as a predictor of prostate volume in men with benign prostatic hyperplasia. Urology 1999;5453:581-589. (Pubitemid 29136206)
    • (1999) Urology , vol.53 , Issue.3 , pp. 581-589
    • Roehrborn, C.G.1    Boyle, P.2    Gould, A.L.3    Waldstreicher, J.4
  • 24
    • 1642330012 scopus 로고    scopus 로고
    • Consensus statement: The role of prostate-specific antigen in managing the patient with benign prostatic hyperplasia
    • Bartsch G, Fitzpatrick JM, Schalken JA, Isaacs J, Nordling J, Roehrborn CG. Consensus statement: The role of prostate-specific antigen in managing the patient with benign prostatic hyperplasia. BJU Int 2004;93(Suppl1):27-29.
    • (2004) BJU Int , vol.93 , Issue.SUPPL. 1 , pp. 27-29
    • Bartsch, G.1    Fitzpatrick, J.M.2    Schalken, J.A.3    Isaacs, J.4    Nordling, J.5    Roehrborn, C.G.6
  • 26
    • 0036754256 scopus 로고    scopus 로고
    • Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia
    • DOI 10.1016/S0090-4295(02)01905-2, PII S0090429502019052
    • Roehrborn CG, Boyle P, Nickel JC, Hoefner K, Andriole G. Efficacy and safety of a dual inhibitor of 5-alpha-reductase types 1 and 2 (dutasteride) in men with benign prostatic hyperplasia. Urology 2002;60:434-441. (Pubitemid 35292169)
    • (2002) Urology , vol.60 , Issue.3 , pp. 434-441
    • Roehrborn, C.G.1    Boyle, P.2    Nickel, J.C.3    Hoefner, K.4    Andriole, G.5
  • 27
    • 4444336295 scopus 로고    scopus 로고
    • Efficacy and safety of long-term treatment with the dual 5α-reductase inhibitor dutasteride in men with symptomatic benign prostatic hyperplasia
    • DOI 10.1016/j.eururo.2004.05.008, PII S0302283804003240
    • Debruyne F, Barkin J, van Erps P, Reis M, Tammela TLJ, Roehrborn C. Efficacy and safety of long-term treatment with the dual 5 alpha-reductase inhibitor dutasteride in men with symptomatic benign prostatic hyperplasia. Eur Urol 2004;46:488-494. (Pubitemid 39200858)
    • (2004) European Urology , vol.46 , Issue.4 , pp. 488-495
    • Debruyne, F.1    Barkin, J.2    Erps, P.V.3    Reis, M.4    Tammela, T.L.J.5    Roehrborn, C.6
  • 30
    • 0033045720 scopus 로고    scopus 로고
    • Finasteride in association with either flutamide or goserelin as combination hormonal therapy in patients with stage M1 carcinoma of the prostate gland
    • DOI 10.1002/(SICI)1097-0045(19990701)40:2<105::AID-PROS6>3.0.CO;2-9
    • Kirby R, Robertson C, Turkes A, Griffiths K, Denis LS, Boyle P, Altwein J, Schröder F. Finasteride in association with either flutamide or goserelin as combination hormonal therapy in patients with stage M1 carcinoma of the prostate gland. Prostate 1999;40:105-114. (Pubitemid 29304701)
    • (1999) Prostate , vol.40 , Issue.2 , pp. 105-114
    • Kirby, R.1    Robertson, C.2    Turkes, A.3    Griffiths, K.4    Denis, L.J.5    Boyle, P.6    Altwein, J.7    Schroder, F.8
  • 31
    • 34848860581 scopus 로고    scopus 로고
    • Combination therapy with dutasteride and tamsulosin in men with moderate-to-severe benign prostatic hyperplasia and prostate enlargement: The CombAT (Combination of Avodart® and Tamsulosin) trial rationale and study design
    • Siami P, Roehrborn CG, Barkin J, Damiao R, Wyczolkowski M, Duggan A, Major-Walker K, Morrill BB. Combination therapy with dutasteride and tamsulosin in men with moderate-to-severe benign prostatic hyperplasia and prostate enlargement: The CombAT (Combination of Avodart® and Tamsulosin) trial rationale and study design. Contemp Clin Trials 2007;28:770-779.
    • (2007) Contemp Clin Trials , vol.28 , pp. 770-779
    • Siami, P.1    Roehrborn, C.G.2    Barkin, J.3    Damiao, R.4    Wyczolkowski, M.5    Duggan, A.6    Major-Walker, K.7    Morrill, B.B.8
  • 32
    • 38849201263 scopus 로고    scopus 로고
    • The effects of dutasteride, tamsulosin and combination therapy on lower urinary tract symptoms in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the CombAT study
    • Roehrborn CG, Siami P, Barkin J, Damiao R, Major-Walker K, Morrill B, Montorsi F. The effects of dutasteride, tamsulosin and combination therapy on lower urinary tract symptoms in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the CombAT study. J Urol 2008;179:616-621.
    • (2008) J Urol , vol.179 , pp. 616-621
    • Roehrborn, C.G.1    Siami, P.2    Barkin, J.3    Damiao, R.4    Major-Walker, K.5    Morrill, B.6    Montorsi, F.7
  • 33
    • 4544248276 scopus 로고    scopus 로고
    • Chemoprevention of prostate cancer in men at high risk: Rationale and design of the reduction by dutasteride of prostate cancer events (REDUCE) trial
    • Andriole G, Bostwick D, Brawley O, Gomella L, Marberger M, Tindall D, Breed S, Somerville M, Rittmaster RI. Chemoprevention of prostate cancer in men at high risk: Rationale and design of the reduction by dutasteride of prostate cancer events (REDUCE) trial. J Urol 2004;172:1314-1317.
    • (2004) J Urol , vol.172 , pp. 1314-1317
    • Andriole, G.1    Bostwick, D.2    Brawley, O.3    Gomella, L.4    Marberger, M.5    Tindall, D.6    Breed, S.7    Somerville, M.8    Rittmaster, R.I.9
  • 35
    • 4444331484 scopus 로고    scopus 로고
    • Effect of dutasteride on the detection of prostate cancer in men with benign prostatic hyperplasia
    • DOI 10.1016/j.urology.2004.04.084, PII S0090429504007393
    • Andriole G, Roehrborn CG, Schulman C, Slawin KM, Somerville M, Rittmaster RS. Effect of dutasteride on the detection of prostate cancer in men with benign prostatic hyperplasia. Urology 2004;64: 537-541. (Pubitemid 39200753)
    • (2004) Urology , vol.64 , Issue.3 , pp. 537-543
    • Andriole, G.L.1    Roehrborn, C.2    Schulman, C.3    Slawin, K.M.4    Somerville, M.5    Rittmaster, R.S.6
  • 36
    • 0036754301 scopus 로고    scopus 로고
    • PSA response to finasteride challenge in men with a serum PSA greater than 4 ng/ml and previous negative prostate biopsy: Preliminary study
    • Kaplan SA, Ghafar MA, Volpe MA, Lam JS, Fromer D, Te AE. PSA response to finasteride challenge in men with a serum PSA greater than 4 ng/ml and previous negative prostate biopsy: Preliminary study. Urology 2002;60:464-468.
    • (2002) Urology , vol.60 , pp. 464-468
    • Kaplan, S.A.1    Ghafar, M.A.2    Volpe, M.A.3    Lam, J.S.4    Fromer, D.5    Te, A.E.6
  • 37
    • 33646006372 scopus 로고    scopus 로고
    • Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5alpha-reductase inhibitor dutasteride
    • Andriole GL, Marberger M, Roehrborn CG. Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5alpha-reductase inhibitor dutasteride. J Urol 2006;175:1657-1662.
    • (2006) J Urol , vol.175 , pp. 1657-1662
    • Andriole, G.L.1    Marberger, M.2    Roehrborn, C.G.3
  • 38
    • 33746543255 scopus 로고    scopus 로고
    • The interpretation of serum prostate specific antigen in men receiving 5a-reductase inhibitors: A review and clinical recommendations
    • Marks LS, Andriole GL, Fitzpatrick JM, Schulman CC, Roehrborn CG. The interpretation of serum prostate specific antigen in men receiving 5a-reductase inhibitors: A review and clinical recommendations. J Urol 2006;176:868-874.
    • (2006) J Urol , vol.176 , pp. 868-874
    • Marks, L.S.1    Andriole, G.L.2    Fitzpatrick, J.M.3    Schulman, C.C.4    Roehrborn, C.G.5
  • 40
    • 34147183350 scopus 로고    scopus 로고
    • Finasteride Improves the Sensitivity of Digital Rectal Examination for Prostate Cancer Detection
    • DOI 10.1016/j.juro.2007.01.071, PII S0022534707000560
    • Thompson IM, Tangen CM, Goodman PJ, Lucia MS, Parnes HL, Lippman SM, Coltman CA Jr. Finasteride improves the sensitivity of digital rectal examination for prostate cancer detection. J Urol 2007;177:1749-1752. (Pubitemid 46560657)
    • (2007) Journal of Urology , vol.177 , Issue.5 , pp. 1749-1752
    • Thompson, I.M.1    Tangen, C.M.2    Goodman, P.J.3    Lucia, M.S.4    Parnes, H.L.5    Lippman, S.M.6    Coltman Jr., C.A.7
  • 41
    • 36448988245 scopus 로고    scopus 로고
    • Dutasteride Prior to Contrast-Enhanced Colour Doppler Ultrasound Prostate Biopsy Increases Prostate Cancer Detection
    • DOI 10.1016/j.eururo.2007.02.031, PII S0302283807002321
    • Mitterberger M, Pinggera G, Horninger W, Strasser H, Halpern E, Pallwein L, Gradl J, Bartsch G, Frauscher F. Dutasteride prior to contrast-enhanced colour Doppler ultrasound prostate biopsy increases prostate cancer detection. Eur Urol 2008;53:112-117. (Pubitemid 350166703)
    • (2008) European Urology , vol.53 , Issue.1 , pp. 112-117
    • Mitterberger, M.1    Pinggera, G.2    Horninger, W.3    Strasser, H.4    Halpern, E.5    Pallwein, L.6    Gradl, J.7    Bartsch, G.8    Frauscher, F.9
  • 42
    • 25144443103 scopus 로고    scopus 로고
    • Effect of dutasteride therapy on Doppler US evaluation of prostate: Preliminary results
    • Ives EP, Gomella LG, Halpern EJ. Effect of dutasteride therapy on Doppler US evaluation of prostate: Preliminary results. Radiology 2005;237:197-201.
    • (2005) Radiology , vol.237 , pp. 197-201
    • Ives, E.P.1    Gomella, L.G.2    Halpern, E.J.3
  • 43
    • 12844279803 scopus 로고    scopus 로고
    • The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate
    • DOI 10.1016/j.urology.2004.08.042, PII S0090429504010155
    • Ickzowski KA, Qiu J, Qian J, Somerville MC, Rittmaster RS, Andriole G, Bostwick DG. The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate. Urology 2005;65:76-82. (Pubitemid 40169609)
    • (2005) Urology , vol.65 , Issue.1 , pp. 76-82
    • Iczkowski, K.A.1    Qiu, J.2    Qian, J.3    Somerville, M.C.4    Rittmaster, R.S.5    Andriole, G.L.6    Bostwick, D.G.7
  • 45
    • 0035060658 scopus 로고    scopus 로고
    • Treatment of localized prostate cancer with intermittent triple androgen blockade: Preliminary results in 110 consecutive patients
    • Leibowitz RL, Tucker SJ. Treatment of localized prostate cancer with intermittent triple androgen blockade: Preliminary results in 110 consecutive patients. Oncologist 2001;6:177-182.
    • (2001) Oncologist , vol.6 , pp. 177-182
    • Leibowitz, R.L.1    Tucker, S.J.2
  • 46
    • 66049108332 scopus 로고    scopus 로고
    • Primary triple androgen blockade (TAB) followed by finasteride maintenance (FM) for clinically localized prostate cancer (CL-PC): Long term follow-up and quality of life (QOL)
    • abstract106. Available from: [accessed 26th June 2008]
    • Tucker S, Roundy JN, Leibowitz R. Primary triple androgen blockade (TAB) followed by finasteride maintenance (FM) for clinically localized prostate cancer (CL-PC): Long term follow-up and quality of life (QOL). 2005 ASCO Prostate Cancer Symposium, abstract106. Available from:http://www.asco.org/ portal/ site/ASCO/menuitem.34d60f5624ba07fd506fe310ee37a01d/ ?vgnextoid=76f8201eb61a7010VgnVCM100000ed730ad1RCRD & vmview=abst-detail- view&confID=37&abstractID=20271 [accessed 26th June 2008].
    • 2005 ASCO Prostate Cancer Symposium
    • Tucker, S.1    Roundy, J.N.2    Leibowitz, R.3
  • 47
    • 66049123767 scopus 로고    scopus 로고
    • Vogelzang N.Longterm efficacy of peripheral and rogen blockade on prostate cancer: CALGB9782
    • 2006 ASCO Annual Meeting Proceedings Part I
    • Picus J, Halabi S, Small E, Hussain A, Philips G, Kaplan E, Vogelzang N.Longterm efficacy of peripheral and rogen blockade on prostate cancer: CALGB9782. J Clin Oncol, 2006 ASCO Annual Meeting Proceedings Part I;24: 4573.
    • J Clin Oncol , vol.24 , pp. 4573
    • Picus, J.1    Halabi, S.2    Small, E.3    Hussain, A.4    Philips, G.5    Kaplan, E.6
  • 48
    • 0037253614 scopus 로고    scopus 로고
    • Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: The Prospective European Doxazosin and Combination Therapy (PREDICT) trial
    • Kirby RS, Roehrborn C, Boyle P, Bartsch G, Jardin A, Cary MC, Sweeney M, Grossman EB. Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: The Prospective European Doxazosin and Combination Therapy (PREDICT) trial. Urology 2003;61:119-126.
    • (2003) Urology , vol.61 , pp. 119-126
    • Kirby, R.S.1    Roehrborn, C.2    Boyle, P.3    Bartsch, G.4    Jardin, A.5    Cary, M.C.6    Sweeney, M.7    Grossman, E.B.8
  • 49
    • 66049161220 scopus 로고    scopus 로고
    • Activity of dutasteride plus ketoconazole in hormone-refractory prostate cancer (HRPC) after progression on ketoconazole alone
    • abstract 257. Available from: [accessed 12th November 2008].
    • Sartor AO, Nakabayashi M, Taplin ME, Ross R, Kantoff P, Balk S, Oh K. Activity of dutasteride plus ketoconazole in hormone-refractory prostate cancer (HRPC) after progression on ketoconazole alone. 2007 ASCO Prostate Cancer Symposium, abstract 257. Available from: http://www.asco.org/portal/site/ASCO/ menuitem.34d60f5624ba07fd506fe310ee37a01d/?vgnextoid= 76f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview= abst-detail- view&confID=46&abstractID=20212 [accessed 12th November 2008].
    • 2007 ASCO Prostate Cancer Symposium
    • Sartor, A.O.1    Nakabayashi, M.2    Taplin, M.E.3    Ross, R.4    Kantoff, P.5    Balk, S.6    Oh, K.7
  • 50
    • 33745815334 scopus 로고    scopus 로고
    • Efficacy of neoadjuvant bicalutamide and dutasteride as a cytoreductive regimen before prostate brachytherapy
    • DOI 10.1016/j.urology.2006.01.061, PII S0090429506001312
    • Merrick GS, Butler WM, Wallner KE, Galbreath RW, Allen ZA, Kurko B. Efficacy of neoadjuvant bicalutamide and dutasteride as a cytoreductive regimen before prostate brachytherapy. Urology 2006;68:116-120. (Pubitemid 44037733)
    • (2006) Urology , vol.68 , Issue.1 , pp. 116-120
    • Merrick, G.S.1    Butler, W.M.2    Wallner, K.E.3    Galbreath, R.W.4    Allen, Z.A.5    Kurko, B.6
  • 51
    • 34548217770 scopus 로고    scopus 로고
    • Low-activity, V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: An explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors
    • Cussenot O, Azzouzi AR, Nicolaiew N, Mangin P, Cormier L, Fournier G, Valeri A, Cancel-Tassin G. Low-activity, V89L variant in SRD5A2 is associated with aggressive prostate cancer risk: An explanation for the adverse effects observed in chemoprevention trials using 5-alpha-reductase inhibitors. Eur Urol 2007;52: 1082-1087.
    • (2007) Eur Urol , vol.52 , pp. 1082-1087
    • Cussenot, O.1    Azzouzi, A.R.2    Nicolaiew, N.3    Mangin, P.4    Cormier, L.5    Fournier, G.6    Valeri, A.7    Cancel-Tassin, G.8
  • 54
    • 34748917019 scopus 로고    scopus 로고
    • Detection bias due to the effect of finasteride on prostate volume: Amodeling approach for analysis of the Prostate Cancer Prevention Trial
    • Cohen YC, Liu KS, Heyden NL, Carides AD, Anderson KM, Daifotis AG, Gann PH. Detection bias due to the effect of finasteride on prostate volume: Amodeling approach for analysis of the Prostate Cancer Prevention Trial. J Natl Cancer Inst 2007;99: 1366-1374.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1366-1374
    • Cohen, Y.C.1    Liu, K.S.2    Heyden, N.L.3    Carides, A.D.4    Anderson, K.M.5    Daifotis, A.G.6    Gann, P.H.7
  • 59
    • 0034162525 scopus 로고    scopus 로고
    • Primary treatment choices for men with clinically localized prostate carcinoma detected by screening
    • DOI 10.1002/(SICI)1097-0142(20000301)88:5<1122::AID-CNCR24>3.0. CO;2-Q
    • Yan Y, Carvalhal GF, Catalona WJ, Young D. Primary treatment choices for men with clinically localized prostate carcinoma detected by screening. Cancer 2000;88:1122-1130. (Pubitemid 30127674)
    • (2000) Cancer , vol.88 , Issue.5 , pp. 1122-1130
    • Yan, Y.1    Carvalhal, G.F.2    Catalona, W.J.3    Young, J.D.4
  • 60
    • 0141919735 scopus 로고    scopus 로고
    • Time trends and characteristics of men choosing watchful waiting for initial treatment of localized prostate cancer: Results from CaPSURE
    • Harlan SR, Cooperberg MR, Elkin EP, Lubeck DP, Meng MV, Mehta SS, Carroll PR. Time trends and characteristics of men choosing watchful waiting for initial treatment of localized prostate cancer: Results from CaPSURE. J Urol 2003;170: 1804-1807.
    • (2003) J Urol , vol.170 , pp. 1804-1807
    • Harlan, S.R.1    Cooperberg, M.R.2    Elkin, E.P.3    Lubeck, D.P.4    Meng, M.V.5    Mehta, S.S.6    Carroll, P.R.7
  • 61
    • 61749093320 scopus 로고    scopus 로고
    • Pathologic characteristics of cancers detected in the Prostate Cancer Prevention Trial: Implications for prostate cancer detection and chemoprevention
    • Lucia MS, Darke AK, Goodman PJ, LaRosa F, Parnes HL, Ford LG, Coltman CA Jr,, Thompson IM. Pathologic characteristics of cancers detected in the Prostate Cancer Prevention Trial: Implications for prostate cancer detection and chemoprevention. Cancer Prev Res 2008;1:167-173.
    • (2008) Cancer Prev Res , vol.1 , pp. 167-173
    • Lucia, M.S.1    Darke, A.K.2    Goodman, P.J.3    LaRosa, F.4    Parnes, H.L.5    Ford, L.G.6    Coltman Jr., C.A.7    Thompson, I.M.8
  • 64
    • 0029240370 scopus 로고
    • Finasteride dose-dependently reduces the proliferation rate of the LnCap human prostatic cancer cell line in vitro
    • Bologna M, Muzi P, Biordi L, Festuccia C, Vicentini C. Finasteride dose-dependently reduces the proliferation rate of the LnCap human prostatic cancer cell line in vitro. Urology 1995;45:282-290.
    • (1995) Urology , vol.45 , pp. 282-290
    • Bologna, M.1    Muzi, P.2    Biordi, L.3    Festuccia, C.4    Vicentini, C.5
  • 65
    • 0742287752 scopus 로고    scopus 로고
    • Dutasteride, the Dual 5α-Reductase Inhibitor, Inhibits Androgen Action and Promotes Cell Death in the LNCaP Prostate Cancer Cell Line
    • DOI 10.1002/pros.10340
    • Lazier CB, Thomas LN, Douglas RC, Vessey JP, Rittmaster RS. Dutasteride, the dual 5a-reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line. Prostate 2004;58:130-144. (Pubitemid 38160900)
    • (2004) Prostate , vol.58 , Issue.2 , pp. 130-144
    • Lazier, C.B.1    Thomas, L.N.2    Douglas, R.C.3    Vessey, J.P.4    Rittmaster, R.S.5
  • 66
    • 33746795081 scopus 로고    scopus 로고
    • Finasteride targets prostate vascularity by inducing apoptosis and inhibiting cell adhesion of benign and malignant prostate cells
    • DOI 10.1002/pros.20444
    • Sutton MT, Yingling M, Vyas A, Atiemo H, Borkowski A, Jacobs SC, Kyprianou N. Finasteride targets prostate vascularity by inducing apoptosis and inhibiting cell adhesion of benign and malignant prostate cells. Prostate 2006;66:1194-1202. (Pubitemid 44175341)
    • (2006) Prostate , vol.66 , Issue.11 , pp. 1194-1202
    • Sutton, M.T.1    Yingling, M.2    Vyas, A.3    Atiemo, H.4    Borkowski, A.5    Jacobs, S.C.6    Kyprianou, N.7
  • 67
    • 33745184934 scopus 로고    scopus 로고
    • Effects of the dual 5 α-reductase inhibitor dutasteride on apoptosis in primary cultures of prostate cancer epithelial cells and cell lines
    • DOI 10.1002/cncr.21938
    • McCrohan A, Morrissey C, OKeane C, Mulligan N, Watson C, Smith J, Fitzpatrick JM, Watson RWG. Effects of the dual 5 alpha-reductase inhibitor dutasteride on apoptosis in primary cultures of prostate cancer epithelial cells and cell lines. Cancer 2006; 106:2743-2752. (Pubitemid 43911845)
    • (2006) Cancer , vol.106 , Issue.12 , pp. 2743-2752
    • McCrohan, A.M.1    Morrissey, C.2    O'Keane, C.3    Mulligan, N.4    Watson, C.5    Smith, J.6    Fitzpatrick, J.M.7    Watson, R.W.G.8
  • 68
    • 33746047132 scopus 로고    scopus 로고
    • Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers
    • DOI 10.1158/1078-0432.CCR-06-0184
    • Xu Y, Dalrymple SL, Becker RE, Denmeade SR, Isaacs JT. Pharmacologic basis for the enhanced efficacy of dutasteride against prostatic cancers. Clin Cancer Res 2006;12:4072-4079. (Pubitemid 44078095)
    • (2006) Clinical Cancer Research , vol.12 , Issue.13 , pp. 4072-4079
    • Xu, Y.1    Dalrymple, S.L.2    Becker, R.E.3    Denmeade, S.R.4    Isaacs, J.T.5
  • 70
    • 14644424687 scopus 로고    scopus 로고
    • Prevalence of conditions potentially associated with lower urinary tract symptoms in men
    • DOI 10.1111/j.1464-410X.2005.05337.x
    • Gades NM, Jacobson DJ, Girman CJ, Roberts RO, Lieber MM, Jacobsen SJ. Prevalence of conditions potentially associated with lower urinary tract symptoms in men. BJU Int 2005;95:549-553. (Pubitemid 40311471)
    • (2005) BJU International , vol.95 , Issue.4 , pp. 549-553
    • Gades, N.M.1    Jacobson, D.J.2    Girman, C.J.3    Roberts, R.O.4    Lieber, M.M.5    Jacobsen, S.J.6
  • 73
    • 60249084794 scopus 로고    scopus 로고
    • Chemoprevention of prostate cancer: Baseline characteristics of men in the REDUCE trial
    • Andriole G, Brawley O, Tammela TL, Rittmaster R. Chemoprevention of prostate cancer: Baseline characteristics of men in the REDUCE trial. Eur Urol Suppl 2005;4:184.
    • (2005) Eur Urol Suppl , vol.4 , pp. 184
    • Andriole, G.1    Brawley, O.2    Tammela, T.L.3    Rittmaster, R.4
  • 74
    • 23244435993 scopus 로고    scopus 로고
    • Lifetime implications and cost-effectiveness of using finasteride to prevent prostate cancer
    • Zeliadt SB, Etzioni RD, Penson DF, Thompson IM, Ramsey SD. Lifetime implications and cost-effectiveness of using finasteride to prevent prostate cancer. Am J Med 2005;118:850-857.
    • (2005) Am J Med , vol.118 , pp. 850-857
    • Zeliadt, S.B.1    Etzioni, R.D.2    Penson, D.F.3    Thompson, I.M.4    Ramsey, S.D.5


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