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Volumn 10, Issue 8, 2010, Pages 1327-1338

Animal models of osteosarcoma

Author keywords

comparative oncology; murine model; primary bone sarcoma; spontaneous dog model; translational investigations

Indexed keywords

IMATINIB; ZOLEDRONIC ACID;

EID: 77956261327     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/era.10.107     Document Type: Review
Times cited : (23)

References (88)
  • 2
    • 0017175489 scopus 로고
    • The WHO classification of bone tumors
    • Sissons HA. The WHO classification of bone tumors. Recent Results Cancer Res. (54), 104-108 (1976).
    • (1976) Recent Results Cancer Res. , vol.54 , pp. 104-108
    • Sissons, H.A.1
  • 3
    • 33645553503 scopus 로고    scopus 로고
    • Osteosarcoma: Anatomic and histologic variants
    • Klein MJ, Siegal GP. Osteosarcoma: anatomic and histologic variants. Am. J. Clin. Pathol. 125(4), 555-581 (2006).
    • (2006) Am. J. Clin. Pathol. , vol.125 , Issue.4 , pp. 555-581
    • Klein, M.J.1    Siegal, G.P.2
  • 5
    • 0000870173 scopus 로고
    • Osteogenic sarcoma of the extraskeletal soft tissues
    • Fine G, Stout AP. Osteogenic sarcoma of the extraskeletal soft tissues. Cancer 9(5), 1027-1043 (1956).
    • (1956) Cancer , vol.9 , Issue.5 , pp. 1027-1043
    • Fine, G.1    Stout, A.P.2
  • 6
    • 0000935897 scopus 로고
    • Extraskeletal osteogenic sarcomas and chondrosarcomas in children
    • Kauffman SL, Stout AP. Extraskeletal osteogenic sarcomas and chondrosarcomas in children. Cancer 16, 432-439 (1963).
    • (1963) Cancer , vol.16 , pp. 432-439
    • Kauffman, S.L.1    Stout, A.P.2
  • 9
    • 77953669219 scopus 로고    scopus 로고
    • The epidemiology of osteosarcoma
    • Ottaviani G, Jaffe N. The epidemiology of osteosarcoma. Cancer Treat. Res. 152, 3-13 (2010).
    • (2010) Cancer Treat. Res. , vol.152 , pp. 3-13
    • Ottaviani, G.1    Jaffe, N.2
  • 12
    • 0015122611 scopus 로고
    • Lymphatic metastases of bone tumors
    • Makai F, Belan A, Malek P. Lymphatic metastases of bone tumors. Lymphology 4(3), 109-115 (1971).
    • (1971) Lymphology , vol.4 , Issue.3 , pp. 109-115
    • Makai, F.1    Belan, A.2    Malek, P.3
  • 13
    • 17644430430 scopus 로고
    • Neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremities: The recent experience at the Rizzoli Institute
    • Bacci G, Picci P, Ferrari S et al. Neoadjuvant chemotherapy for nonmetastatic osteosarcoma of the extremities: the recent experience at the Rizzoli Institute. Cancer Treat. Res. 62, 299-308 (1993).
    • (1993) Cancer Treat. Res. , vol.62 , pp. 299-308
    • Bacci, G.1    Picci, P.2    Ferrari, S.3
  • 14
    • 34249999670 scopus 로고    scopus 로고
    • Adjuvant and neoadjuvant combination chemotherapy for osteogenic sarcoma
    • Ferrari S, Palmerini E. Adjuvant and neoadjuvant combination chemotherapy for osteogenic sarcoma. Curr. Opin. Oncol. 19(4), 341-346 (2007).
    • (2007) Curr. Opin. Oncol. , vol.19 , Issue.4 , pp. 341-346
    • Ferrari, S.1    Palmerini, E.2
  • 15
    • 3543035771 scopus 로고    scopus 로고
    • Biology and therapeutic advances for pediatric osteosarcoma
    • Marina N, Gebhardt M, Teot L, Gorlick R. Biology and therapeutic advances for pediatric osteosarcoma. Oncologist 9(4), 422-441 (2004).
    • (2004) Oncologist. , vol.9 , Issue.4 , pp. 422-441
    • Marina, N.1    Gebhardt, M.2    Teot, L.3    Gorlick, R.4
  • 16
    • 70449369314 scopus 로고    scopus 로고
    • Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: A report from the childrens oncology group
    • Chou AJ, Kleinerman ES, Krailo MD et al. Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group. Cancer 115(22), 5339-5348 (2009).
    • (2009) Cancer , vol.115 , Issue.22 , pp. 5339-5348
    • Chou, A.J.1    Kleinerman, E.S.2    Krailo, M.D.3
  • 17
    • 20144380941 scopus 로고    scopus 로고
    • Osteosarcoma: A randomized prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin doxorubicin and high-dose methotrexate
    • Meyers PA, Schwartz CL, Krailo M et al. Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate. J. Clin. Oncol. 23(9), 2004-2011 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.9 , pp. 2004-2011
    • Meyers, P.A.1    Schwartz, C.L.2    Krailo, M.3
  • 18
    • 0026318628 scopus 로고
    • Molecular genetic considerations in osteosarcoma
    • Hansen MF. Molecular genetic considerations in osteosarcoma. Clin. Orthop. Relat. Res. (270), 237-246 (1991).
    • (1991) Clin. Orthop. Relat. Res. , vol.270 , pp. 237-246
    • Hansen, M.F.1
  • 19
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer sarcomas and other neoplasms
    • Malkin D, Li FP, Strong LC et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 250(4985), 1233-1238 (1990).
    • (1990) Science , vol.250 , Issue.4985 , pp. 1233-1238
    • Malkin, D.1    Li, F.P.2    Strong, L.C.3
  • 20
    • 0029791852 scopus 로고    scopus 로고
    • Alterations of the p53 Rb and MDM2 genes in osteosarcoma
    • Miller CW, Aslo A, Won A et al. Alterations of the p53, Rb and MDM2 genes in osteosarcoma. J. Cancer Res. Clin. Oncol. 122(9), 559-565 (1996).
    • (1996) J. Cancer Res. Clin. Oncol. , vol.122 , Issue.9 , pp. 559-565
    • Miller, C.W.1    Aslo, A.2    Won, A.3
  • 21
    • 0028946875 scopus 로고
    • Incidence of cancer in children in the United States. Sex-race-and 1-year age-specific rates by histologic type
    • Gurney JG, Severson RK, Davis S, Robison LL. Incidence of cancer in children in the United States. Sex-, race-, and 1-year age-specific rates by histologic type. Cancer 75(8), 2186-2195 (1995).
    • (1995) Cancer , vol.75 , Issue.8 , pp. 2186-2195
    • Gurney, J.G.1    Severson, R.K.2    Davis, S.3    Robison, L.L.4
  • 22
    • 0028276710 scopus 로고
    • Mutation spectrum of the retinoblastoma gene in osteosarcomas
    • Wadayama B, Toguchida J, Shimizu T et al. Mutation spectrum of the retinoblastoma gene in osteosarcomas. Cancer Res. 54(11), 3042-3048 (1994).
    • (1994) Cancer Res. , vol.54 , Issue.11 , pp. 3042-3048
    • Wadayama, B.1    Toguchida, J.2    Shimizu, T.3
  • 23
    • 0022402666 scopus 로고
    • Osteosarcoma and retinoblastoma: A shared chromosomal mechanism revealing recessive predisposition
    • USA
    • Hansen MF, Koufos A, Gallie BL et al. Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition. Proc. Natl Acad. Sci. USA 82(18), 6216-6220 (1985).
    • (1985) Proc. Natl Acad. Sci. , vol.82 , Issue.18 , pp. 6216-6220
    • Hansen, M.F.1    Koufos, A.2    Gallie, B.L.3
  • 24
    • 0029006771 scopus 로고
    • Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue
    • Puranam KL, Kennington E, Sait SN et al. Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue. Genomics 26(3), 595-598 (1995).
    • (1995) Genomics. , vol.26 , Issue.3 , pp. 595-598
    • Puranam, K.L.1    Kennington, E.2    Sait, S.N.3
  • 25
    • 0030091256 scopus 로고    scopus 로고
    • Failure to unwind causes cancer. Genome stability
    • Watt PM, Hickson ID. Failure to unwind causes cancer. Genome stability. Curr. Biol. 6(3), 265-267 (1996).
    • (1996) Curr. Biol. , vol.6 , Issue.3 , pp. 265-267
    • Watt, P.M.1    Hickson, I.D.2
  • 26
    • 0035062128 scopus 로고    scopus 로고
    • DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders
    • Mohaghegh P, Hickson ID. DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders. Hum. Mol. Genet. 10(7), 741-746 (2001).
    • (2001) Hum. Mol. Genet. , vol.10 , Issue.7 , pp. 741-746
    • Mohaghegh, P.1    Hickson, I.D.2
  • 27
    • 0038288850 scopus 로고    scopus 로고
    • Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome
    • Wang LL, Gannavarapu A, Kozinetz CA et al. Association between osteosarcoma and deleterious mutations in the RECQL4 gene in Rothmund-Thomson syndrome. J. Natl Cancer Inst. 95(9), 669-674 (2003).
    • (2003) J. Natl Cancer Inst. , vol.95 , Issue.9 , pp. 669-674
    • Wang, L.L.1    Gannavarapu, A.2    Kozinetz, C.A.3
  • 28
    • 0038756405 scopus 로고    scopus 로고
    • Update on the biology and management of canine osteosarcoma
    • Chun R, de Lorimier LP. Update on the biology and management of canine osteosarcoma. Vet. Clin. North Am. Small Anim. Pract. 33(3), 491-516 (2003).
    • (2003) Vet. Clin. North Am. Small Anim. Pract. , vol.33 , Issue.3 , pp. 491-516
    • Chun, R.1    De Lorimier, L.P.2
  • 29
    • 0026497861 scopus 로고
    • Malignant transformation in Paget disease of bone
    • Hadjipavlou A, Lander P, Srolovitz H, Enker IP. Malignant transformation in Paget disease of bone. Cancer 70(12), 2802-2808 (1992).
    • (1992) Cancer , vol.70 , Issue.12 , pp. 2802-2808
    • Hadjipavlou, A.1    Lander, P.2    Srolovitz, H.3    Enker, I.P.4
  • 31
    • 0023239053 scopus 로고
    • Bone sarcomas linked to radiotherapy and chemotherapy in children
    • Tucker MA, D'Angio GJ, Boice JD Jr et al. Bone sarcomas linked to radiotherapy and chemotherapy in children. N. Engl. J. Med. 317(10), 588-593 (1987).
    • (1987) N. Engl. J. Med. , vol.317 , Issue.10 , pp. 588-593
    • Tucker, M.A.1    D'Angio, G.J.2    Boice Jr., J.D.3
  • 32
    • 0019513225 scopus 로고
    • Neoplasms induced by megavoltage radiation in the head and neck region
    • Steeves RA, Bataini JP. Neoplasms induced by megavoltage radiation in the head and neck region. Cancer 47(7), 1770-1774 (1981).
    • (1981) Cancer , vol.47 , Issue.7 , pp. 1770-1774
    • Steeves, R.A.1    Bataini, J.P.2
  • 33
    • 0025055742 scopus 로고
    • Radiation-induced osteosarcoma in dogs after external beam or intraoperative radiation therapy
    • Gillette SM, Gillette EL, Powers BE, Withrow SJ. Radiation-induced osteosarcoma in dogs after external beam or intraoperative radiation therapy. Cancer Res. 50(1), 54-57 (1990).
    • (1990) Cancer Res. , vol.50 , Issue.1 , pp. 54-57
    • Gillette, S.M.1    Gillette, E.L.2    Powers, B.E.3    Withrow, S.J.4
  • 34
    • 50149110590 scopus 로고    scopus 로고
    • Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage
    • USA
    • Berman SD, Calo E, Landman AS et al. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proc. Natl Acad. Sci. USA 105(33), 11851-11856 (2008).
    • (2008) Proc. Natl Acad. Sci. , vol.105 , Issue.33 , pp. 11851-11856
    • Berman, S.D.1    Calo, E.2    Landman, A.S.3
  • 35
    • 45349086509 scopus 로고    scopus 로고
    • Conditional mouse osteosarcoma dependent on p53 loss and potentiated by loss of Rb mimics the human disease
    • Walkley CR, Qudsi R, Sankaran VG et al. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev. 22(12), 1662-1676 (2008).
    • (2008) Genes Dev. , vol.22 , Issue.12 , pp. 1662-1676
    • Walkley, C.R.1    Qudsi, R.2    Sankaran, V.G.3
  • 36
    • 0034193321 scopus 로고    scopus 로고
    • Temporal progression of metastasis in lung: Cell survival dormancy and location dependence of metastatic inefficiency
    • Cameron MD, Schmidt EE, Kerkvliet N et al. Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency. Cancer Res. 60(9), 2541-2546 (2000).
    • (2000) Cancer Res. , vol.60 , Issue.9 , pp. 2541-2546
    • Cameron, M.D.1    Schmidt, E.E.2    Kerkvliet, N.3
  • 37
    • 0029030510 scopus 로고
    • Fate of melanoma cells entering the microcirculation: Over 80% survive and extravasate
    • Koop S, MacDonald IC, Luzzi K et al. Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate. Cancer Res. 55(12), 2520-2523 (1995).
    • (1995) Cancer Res. , vol.55 , Issue.12 , pp. 2520-2523
    • Koop, S.1    MacDonald, I.C.2    Luzzi, K.3
  • 38
    • 0015012399 scopus 로고
    • Cultivation in vitro of cells derived from a human osteosarcoma
    • McAllister RM, Gardner MB, Greene AE et al. Cultivation in vitro of cells derived from a human osteosarcoma. Cancer 27(2), 397-402 (1971).
    • (1971) Cancer , vol.27 , Issue.2 , pp. 397-402
    • McAllister, R.M.1    Gardner, M.B.2    Greene, A.E.3
  • 39
    • 0016648066 scopus 로고
    • Childhood sarcomas and lymphomas. Characterization of new cell lines and search for type-C virus
    • McAllister RM, Nelson-Rees WA, Peer M et al. Childhood sarcomas and lymphomas. Characterization of new cell lines and search for type-C virus. Cancer 36(5), 1804-1814 (1975).
    • (1975) Cancer , vol.36 , Issue.5 , pp. 1804-1814
    • McAllister, R.M.1    Nelson-Rees, W.A.2    Peer, M.3
  • 40
    • 25444481809 scopus 로고    scopus 로고
    • An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis
    • Luu HH, Kang Q, Park JK et al. An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis. Clin. Exp. Metastasis 22(4), 319-329 (2005).
    • (2005) Clin. Exp. Metastasis , vol.22 , Issue.4 , pp. 319-329
    • Luu, H.H.1    Kang, Q.2    Park, J.K.3
  • 41
    • 0027449196 scopus 로고
    • Development of a novel spontaneous metastasis model of human osteosarcoma transplanted orthotopically into bone of athymic mice
    • Berlin O, Samid D, Donthineni-Rao R et al. Development of a novel spontaneous metastasis model of human osteosarcoma transplanted orthotopically into bone of athymic mice. Cancer Res. 53(20), 4890-4895 (1993).
    • (1993) Cancer Res. , vol.53 , Issue.20 , pp. 4890-4895
    • Berlin, O.1    Samid, D.2    Donthineni-Rao, R.3
  • 42
    • 0036847703 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571
    • McGary EC, Weber K, Mills L et al. Inhibition of platelet-derived growth factor-mediated proliferation of osteosarcoma cells by the novel tyrosine kinase inhibitor STI571. Clin. Cancer Res. 8(11), 3584-3591 (2002).
    • (2002) Clin.Cancer Res. , vol.8 , Issue.11 , pp. 3584-3591
    • McGary, E.C.1    Weber, K.2    Mills, L.3
  • 43
    • 0347594110 scopus 로고    scopus 로고
    • A fully human antimelanoma cellular adhesion molecule/MUC18 antibody inhibits spontaneous pulmonary metastasis of osteosarcoma cells in vivo
    • McGary EC, Heimberger A, Mills L et al. A fully human antimelanoma cellular adhesion molecule/MUC18 antibody inhibits spontaneous pulmonary metastasis of osteosarcoma cells in vivo. Clin. Cancer Res. 9(17), 6560-6566 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.17 , pp. 6560-6566
    • McGary, E.C.1    Heimberger, A.2    Mills, L.3
  • 44
    • 66149165883 scopus 로고    scopus 로고
    • Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse model
    • Labrinidis A, Hay S, Liapis V et al. Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse model. Clin. Cancer Res. 15(10), 3451-3461 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.10 , pp. 3451-3461
    • Labrinidis, A.1    Hay, S.2    Liapis, V.3
  • 45
    • 0016692859 scopus 로고
    • The relationship between tumorigenicity growth in agar and fibrinolytic activity in a line of human osteosarcoma cells
    • Jones PA, Rhim JS, Isaacs H Jr, McAllister RM. The relationship between tumorigenicity, growth in agar and fibrinolytic activity in a line of human osteosarcoma cells. Int. J. Cancer 16(4), 616-621 (1975).
    • (1975) Int. J. Cancer , vol.16 , Issue.4 , pp. 616-621
    • Jones, P.A.1    Rhim, J.S.2    Isaacs Jr., H.3    McAllister, R.M.4
  • 46
    • 0017325614 scopus 로고
    • Characterization of human cells transformed in vitro by N-methyl-N′-nitro- N-nitrosoguanidine
    • Rhim JS, Putman DL, Arnstein P, Huebner RJ, McAllister RM. Characterization of human cells transformed in vitro by N-methyl-N′-nitro- N-nitrosoguanidine. Int. J. Cancer 19(4), 505-510 (1977).
    • (1977) Int. J. Cancer , vol.19 , Issue.4 , pp. 505-510
    • Rhim, J.S.1    Putman, D.L.2    Arnstein, P.3    Huebner, R.J.4    McAllister, R.M.5
  • 47
    • 50649124475 scopus 로고    scopus 로고
    • Dominant negative LRP5 decreases tumorigenicity and metastasis ofosteosarcoma in an animal model
    • Guo Y, Rubin EM, Xie J, Zi X, Hoang BH. Dominant negative LRP5 decreases tumorigenicity and metastasis ofosteosarcoma in an animal model. Clin. Orthop. Relat. Res. 466(9), 2039-2045 (2008).
    • (2008) Clin. Orthop. Relat. Res. , vol.466 , Issue.9 , pp. 2039-2045
    • Guo, Y.1    Rubin, E.M.2    Xie, J.3    Zi, X.4    Hoang, B.H.5
  • 48
    • 77949667984 scopus 로고    scopus 로고
    • Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma
    • Rubin EM, Guo Y, Tu K et al. Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. Mol. Cancer Ther. 9(3), 731-741 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.3 , pp. 731-741
    • Rubin, E.M.1    Guo, Y.2    Tu, K.3
  • 49
    • 70349230857 scopus 로고    scopus 로고
    • In vivo gene transfer between interacting human osteosarcoma cell lines is associated with acquisition of enhanced metastatic potential
    • Tome Y, Tsuchiya H, Hayashi K et al. In vivo gene transfer between interacting human osteosarcoma cell lines is associated with acquisition of enhanced metastatic potential. J. Cell. Biochem. 108(2), 362-367 (2009).
    • (2009) J. Cell. Biochem. , vol.108 , Issue.2 , pp. 362-367
    • Tome, Y.1    Tsuchiya, H.2    Hayashi, K.3
  • 50
    • 65349183428 scopus 로고    scopus 로고
    • Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium
    • Hayashi K, Zhao M, Yamauchi K et al. Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium. Cell Cycle 8(6), 870-875 (2009).
    • (2009) Cell. Cycle. , vol.8 , Issue.6 , pp. 870-875
    • Hayashi, K.1    Zhao, M.2    Yamauchi, K.3
  • 51
    • 0017412603 scopus 로고
    • One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice
    • Fogh J, Fogh JM, Orfeo T. One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice. J. Natl Cancer Inst. 59(1), 221-226 (1977).
    • (1977) J. Natl Cancer Inst. , vol.59 , Issue.1 , pp. 221-226
    • Fogh, J.1    Fogh, J.M.2    Orfeo, T.3
  • 52
    • 0033504341 scopus 로고    scopus 로고
    • A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies
    • Jia SF, Worth LL, Kleinerman ES. A nude mouse model of human osteosarcoma lung metastases for evaluating new therapeutic strategies. Clin. Exp. Metastasis 17(6), 501-506 (1999).
    • (1999) Clin. Exp. Metastasis , vol.17 , Issue.6 , pp. 501-506
    • Jia, S.F.1    Worth, L.L.2    Kleinerman, E.S.3
  • 53
  • 54
    • 33846651513 scopus 로고    scopus 로고
    • A novel orthotopic murine model provides insights into cellular and molecular characteristics contributing to human osteosarcoma
    • Dass CR, Ek ET, Contreras KG, Choong PF. A novel orthotopic murine model provides insights into cellular and molecular characteristics contributing to human osteosarcoma. Clin. Exp. Metastasis 23(7-8), 367-380 (2006).
    • (2006) Clin. Exp. Metastasis , vol.23 , Issue.7-8 , pp. 367-380
    • Dass, C.R.1    Ek, E.T.2    Contreras, K.G.3    Choong, P.F.4
  • 55
    • 34247621392 scopus 로고    scopus 로고
    • Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor
    • Ek ET, Dass CR, Contreras KG, Choong PF. Inhibition of orthotopic osteosarcoma growth and metastasis by multitargeted antitumor activities of pigment epithelium-derived factor. Clin. Exp. Metastasis 24(2), 93-106 (2007).
    • (2007) Clin. Exp. Metastasis , vol.24 , Issue.2 , pp. 93-106
    • Ek, E.T.1    Dass, C.R.2    Contreras, K.G.3    Choong, P.F.4
  • 56
    • 34250352217 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth angiogenesis and metastasis
    • Ek ET, Dass CR, Contreras KG, Choong PF. Pigment epithelium-derived factor overexpression inhibits orthotopic osteosarcoma growth, angiogenesis and metastasis. Cancer Gene Ther. 14(7), 616-626 (2007).
    • (2007) Cancer Gene. Ther. , vol.14 , Issue.7 , pp. 616-626
    • Ek, E.T.1    Dass, C.R.2    Contreras, K.G.3    Choong, P.F.4
  • 57
    • 37349015911 scopus 로고    scopus 로고
    • PEDF-derived synthetic peptides exhibit antitumor activity in an orthotopic model of human osteosarcoma
    • Ek ET, Dass CR, Contreras KG, Choong PF. PEDF-derived synthetic peptides exhibit antitumor activity in an orthotopic model of human osteosarcoma. J. Orthop. Res. 25(12), 1671-1680 (2007).
    • (2007) J. Orthop. Res. , vol.25 , Issue.12 , pp. 1671-1680
    • Ek, E.T.1    Dass, C.R.2    Contreras, K.G.3    Choong, P.F.4
  • 58
    • 37549048038 scopus 로고    scopus 로고
    • Zoledronic acid inhibits osteosarcoma growth in an orthotopic model
    • 12 Pt 1
    • Dass CR, Choong PF. Zoledronic acid inhibits osteosarcoma growth in an orthotopic model. Mol. Cancer Ther. 6(12 Pt 1), 3263-3270 (2007).
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 3263-3270
    • Dass, C.R.1    Choong, P.F.2
  • 59
    • 34147185229 scopus 로고    scopus 로고
    • Chitosan microparticles encapsulating PEDF plasmid demonstrate efficacy in an orthotopic metastatic model of osteosarcoma
    • Dass CR, Contreras KG, Dunstan DE, Choong PF. Chitosan microparticles encapsulating PEDF plasmid demonstrate efficacy in an orthotopic metastatic model of osteosarcoma. Biomaterials 28(19), 3026-3033 (2007).
    • (2007) Biomaterials , vol.28 , Issue.19 , pp. 3026-3033
    • Dass, C.R.1    Contreras, K.G.2    Dunstan, D.E.3    Choong, P.F.4
  • 60
    • 0017251894 scopus 로고
    • Parathyroid hormone-responsive adenylate cyclase in induced transplantable osteogenic rat sarcoma
    • Martin TJ, Ingleton PM, Underwood JC et al. Parathyroid hormone-responsive adenylate cyclase in induced transplantable osteogenic rat sarcoma. Nature 260(5550), 436-438 (1976).
    • (1976) Nature. , vol.260 , Issue.5550 , pp. 436-438
    • Martin, T.J.1    Ingleton, P.M.2    Underwood, J.C.3
  • 61
    • 0034896298 scopus 로고    scopus 로고
    • The expression of the urokinase plasminogen activator system in metastatic murine osteosarcoma: An in vivo mouse model
    • Fisher JL, Mackie PS, Howard ML, Zhou H, Choong PF. The expression of the urokinase plasminogen activator system in metastatic murine osteosarcoma: an in vivo mouse model. Clin. Cancer Res. 7(6), 1654-1660 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , Issue.6 , pp. 1654-1660
    • Fisher, J.L.1    Mackie, P.S.2    Howard, M.L.3    Zhou, H.4    Choong, P.F.5
  • 62
    • 0024166354 scopus 로고
    • Establishment and characterization of osteogenic cell lines from a spontaneous murine osteosarcoma
    • Schmidt J, Strauss GP, Schon A et al. Establishment and characterization of osteogenic cell lines from a spontaneous murine osteosarcoma. Differentiation 39(3), 151-160 (1988).
    • (1988) Differentiation , vol.39 , Issue.3 , pp. 151-160
    • Schmidt, J.1    Strauss, G.P.2    Schon, A.3
  • 63
    • 0035057571 scopus 로고    scopus 로고
    • An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential
    • Khanna C, Prehn J, Yeung C et al. An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential. Clin. Exp. Metastasis 18(3), 261-271 (2000).
    • (2000) Clin. Exp. Metastasis , vol.18 , Issue.3 , pp. 261-271
    • Khanna, C.1    Prehn, J.2    Yeung, C.3
  • 64
    • 16844366544 scopus 로고    scopus 로고
    • Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma
    • Wan X, Mendoza A, Khanna C, Helman LJ. Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res. 65(6), 2406-2411 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.6 , pp. 2406-2411
    • Wan, X.1    Mendoza, A.2    Khanna, C.3    Helman, L.J.4
  • 65
    • 33645732440 scopus 로고    scopus 로고
    • CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-b
    • Terabe M, Khanna C, Bose S et al. CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptor-signal transducer and activator of transcription 6 or transforming growth factor-b. Cancer Res. 66(7), 3869-3875 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.7 , pp. 3869-3875
    • Terabe, M.1    Khanna, C.2    Bose, S.3
  • 66
    • 51049119424 scopus 로고    scopus 로고
    • Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton
    • Barkan D, Kleinman H, Simmons JL et al. Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res. 68(15), 6241-6250 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.15 , pp. 6241-6250
    • Barkan, D.1    Kleinman, H.2    Simmons, J.L.3
  • 67
    • 34247595587 scopus 로고    scopus 로고
    • Immune reconstitution prevents metastatic recurrence of murine osteosarcoma
    • Merchant MS, Melchionda F, Sinha M et al. Immune reconstitution prevents metastatic recurrence of murine osteosarcoma. Cancer Immunol. Immunother. 56(7), 1037-1046 (2007).
    • (2007) Cancer Immunol. Immunother. , vol.56 , Issue.7 , pp. 1037-1046
    • Merchant, M.S.1    Melchionda, F.2    Sinha, M.3
  • 68
    • 34547686124 scopus 로고    scopus 로고
    • Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells enhances their metastatic potential and reduces the effect of aerosol gemcitabine
    • 15 Pt 1
    • Gordon N, Koshkina NV, Jia SF et al. Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential, and reduces the effect of aerosol gemcitabine. Clin. Cancer Res. 13(15 Pt 1), 4503-4510 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , pp. 4503-4510
    • Gordon, N.1    Koshkina, N.V.2    Jia, S.F.3
  • 69
    • 58249117638 scopus 로고    scopus 로고
    • Inhibition of AP-1 transcriptional activity blocks the migration invasion and experimental metastasis of murine osteosarcoma
    • Leaner VD, Chick JF, Donninger H et al. Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma. Am. J. Pathol. 174(1), 265-275 (2009).
    • (2009) Am. J. Pathol. , vol.174 , Issue.1 , pp. 265-275
    • Leaner, V.D.1    Chick, J.F.2    Donninger, H.3
  • 70
    • 63449132960 scopus 로고    scopus 로고
    • Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I
    • Hong SH, Briggs J, Newman R et al. Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I. Int. J. Cancer 124(9), 2042-2049 (2009).
    • (2009) Int. J. Cancer , vol.124 , Issue.9 , pp. 2042-2049
    • Hong, S.H.1    Briggs, J.2    Newman, R.3
  • 71
    • 42449111736 scopus 로고    scopus 로고
    • Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases
    • Kim SY, Lee CH, Midura BV et al. Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases. Clin. Exp. Metastasis 25(3), 201-211 (2008).
    • (2008) Clin. Exp. Metastasis , vol.25 , Issue.3 , pp. 201-211
    • Kim, S.Y.1    Lee, C.H.2    Midura, B.V.3
  • 72
    • 46649087152 scopus 로고    scopus 로고
    • A mouse model of pulmonary metastasis from spontaneous osteosarcoma monitored in vivo by Luciferase imaging
    • Miretti S, Roato I, Taulli R et al. A mouse model of pulmonary metastasis from spontaneous osteosarcoma monitored in vivo by Luciferase imaging. PLoS ONE 3(3), e1828 (2008).
    • (2008) Plos. One , vol.3 , Issue.3
    • Miretti, S.1    Roato, I.2    Taulli, R.3
  • 73
    • 0031776414 scopus 로고    scopus 로고
    • Establishment and characterization of a murine osteosarcoma cell line LM8 with high metastatic potential to the lung
    • Asai T, Ueda T, Itoh K et al. Establishment and characterization of a murine osteosarcoma cell line (LM8) with high metastatic potential to the lung. Int. J. Cancer 76(3), 418-422 (1998).
    • (1998) Int. J. Cancer , vol.76 , Issue.3 , pp. 418-422
    • Asai, T.1    Ueda, T.2    Itoh, K.3
  • 74
    • 77950861307 scopus 로고    scopus 로고
    • An orthotopic postsurgical model of luciferase transfected murine osteosarcoma with spontaneous metastasis
    • Sottnik JL, Duval DL, Ehrhart EJ, Thamm DH. An orthotopic, postsurgical model of luciferase transfected murine osteosarcoma with spontaneous metastasis. Clin. Exp. Metastasis 27(3), 151-160 (2010).
    • (2010) Clin. Exp. Metastasis , vol.27 , Issue.3 , pp. 151-160
    • Sottnik, J.L.1    Duval, D.L.2    Ehrhart, E.J.3    Thamm, D.H.4
  • 75
    • 0024041732 scopus 로고
    • Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1
    • USA
    • Sauer B, Henderson N. Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1. Proc. Natl Acad. Sci. USA 85(14), 5166-5170 (1988).
    • (1988) Proc. Natl Acad. Sci. , vol.85 , Issue.14 , pp. 5166-5170
    • Sauer, B.1    Henderson, N.2
  • 76
    • 33847693960 scopus 로고    scopus 로고
    • Comparative biology of human and canine osteosarcoma
    • Mueller F, Fuchs B, Kaser-Hotz B. Comparative biology of human and canine osteosarcoma. Anticancer Res. 27(1A), 155-164 (2007).
    • (2007) Anticancer Res. , vol.27 , Issue.1 A , pp. 155-164
    • Mueller, F.1    Fuchs, B.2    Kaser-Hotz, B.3
  • 78
    • 0033671255 scopus 로고    scopus 로고
    • Spontaneously occurring tumors of companion animals as models for human cancer
    • Vail DM, MacEwen EG. Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Invest. 18(8), 781-792 (2000).
    • (2000) Cancer Invest. , vol.18 , Issue.8 , pp. 781-792
    • Vail, D.M.1    MacEwen, E.G.2
  • 79
    • 0031014338 scopus 로고    scopus 로고
    • P53 gene mutations in osteosarcomas in the dog
    • van Leeuwen IS, Cornelisse CJ, Misdorp W et al. P53 gene mutations in osteosarcomas in the dog. Cancer Lett. 111(1-2), 173-178 (1997).
    • (1997) Cancer Lett. , vol.111 , Issue.1-2 , pp. 173-178
    • Van Leeuwen, I.S.1    Cornelisse, C.J.2    Misdorp, W.3
  • 80
    • 0031869268 scopus 로고    scopus 로고
    • Mutation of the p53 tumor suppressor gene in spontaneously occurring osteosarcomas of the dog
    • Johnson AS, Couto CG, Weghorst CM. Mutation of the p53 tumor suppressor gene in spontaneously occurring osteosarcomas of the dog. Carcinogenesis 19(1), 213-217 (1998).
    • (1998) Carcinogenesis , vol.19 , Issue.1 , pp. 213-217
    • Johnson, A.S.1    Couto, C.G.2    Weghorst, C.M.3
  • 81
    • 0033631464 scopus 로고    scopus 로고
    • Inactivation of p53 and retinoblastoma family pathways in canine osteosarcoma cell lines
    • Levine RA, Fleischli MA. Inactivation of p53 and retinoblastoma family pathways in canine osteosarcoma cell lines. Vet. Pathol. 37(1), 54-61 (2000).
    • (2000) Vet. Pathol. , vol.37 , Issue.1 , pp. 54-61
    • Levine, R.A.1    Fleischli, M.A.2
  • 82
    • 0036583531 scopus 로고    scopus 로고
    • Tumor suppressor pten is mutated in canine osteosarcoma cell lines and tumors
    • Levine RA, Forest T, Smith C. Tumor suppressor PTEN is mutated in canine osteosarcoma cell lines and tumors. Vet. Pathol. 39(3), 372-378 (2002).
    • (2002) Vet. Pathol. , vol.39 , Issue.3 , pp. 372-378
    • Levine, R.A.1    Forest, T.2    Smith, C.3
  • 83
    • 0034069163 scopus 로고    scopus 로고
    • MET oncogene aberrant expression in canine osteosarcoma
    • Ferracini R, Angelini P, Cagliero E et al. MET oncogene aberrant expression in canine osteosarcoma. J. Orthop. Res. 18(2), 253-256 (2000).
    • (2000) J. Orthop. Res. , vol.18 , Issue.2 , pp. 253-256
    • Ferracini, R.1    Angelini, P.2    Cagliero, E.3
  • 84
    • 0041736272 scopus 로고    scopus 로고
    • C-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells
    • MacEwen EG, Kutzke J, Carew J et al. c-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells. Clin. Exp. Metastasis 20(5), 421-430 (2003).
    • (2003) Clin. Exp. Metastasis , vol.20 , Issue.5 , pp. 421-430
    • MacEwen, E.G.1    Kutzke, J.2    Carew, J.3
  • 85
    • 67650083306 scopus 로고    scopus 로고
    • Met oncogene activation qualifies spontaneous canine osteosarcoma as a suitable pre-clinical model of human osteosarcoma
    • De Maria R, Miretti S, Iussich S et al. MET oncogene activation qualifies spontaneous canine osteosarcoma as a suitable pre-clinical model of human osteosarcoma. J. Pathol. 218(3), 399-408 (2009).
    • (2009) J. Pathol. , vol.218 , Issue.3 , pp. 399-408
    • De Maria, R.1    Miretti, S.2    Iussich, S.3
  • 86
    • 11144357298 scopus 로고    scopus 로고
    • The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
    • Khanna C, Wan X, Bose S et al. The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat. Med. 10(2), 182-186 (2004).
    • (2004) Nat. Med. , vol.10 , Issue.2 , pp. 182-186
    • Khanna, C.1    Wan, X.2    Bose, S.3
  • 87
    • 77449128013 scopus 로고    scopus 로고
    • Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression
    • Paoloni M, Davis S, Lana S et al. Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression. BMC Genomics 10, 625 (2009).
    • (2009) BMC Genomics. , vol.10 , pp. 625
    • Paoloni, M.1    Davis, S.2    Lana, S.3
  • 88
    • 33744495087 scopus 로고    scopus 로고
    • Identification of a novel germline met mutation in dogs
    • Liao AT, McMahon M, London CA. Identification of a novel germline MET mutation in dogs. Anim. Genet. 37(3), 248-252 (2006).
    • (2006) Anim. Genet. , vol.37 , Issue.3 , pp. 248-252
    • Liao, A.T.1    McMahon, M.2    London, C.A.3


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