Trauma-induced inflammation and fracture healing

Journal of Orthopaedic Trauma

Volumn 24, Issue 9, 2010, Pages 522-525

  Pape, Hans Christophe ^a   Marcucio, Ralph ^b   Humphrey, Catherine ^c   Colnot, Celine ^b   Knobe, Matthias ^a   Harvey, Edward J ^d  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ROCHESTER   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

bone; fracture; healing; inflammation; stem cells

Indexed keywords

GELATINASE B; TRANSFORMING GROWTH FACTOR BETA;

BONE INJURY; BONE MARROW CELL; CELL MIGRATION; CLINICAL FEATURE; FRACTURE FIXATION; FRACTURE HEALING; HUMAN; INFLAMMATION; MESENCHYMAL STEM CELL; OSTEOBLAST; OXYGEN TENSION; PRIORITY JOURNAL; REVIEW;

ANTI-INFLAMMATORY AGENTS; CELL DIFFERENTIATION; FRACTURE HEALING; FRACTURES, BONE; HUMANS; INFLAMMATION;

EID: 77956252005     PISSN: 08905339     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOT.0b013e3181ed1361     Document Type: Review

References (30)

1. Tsiridis E, Upadhyay N, Giannoudis P. Molecular aspects of fracture healing: which are the important molecules? Injury. 2007;38(Suppl 1): S11-S25.
2. Gerstenfeld LC, Cullinane DM, Barnes GL, et al. Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem. 2003;88:873-884.
3. Lenz A, Franklin GA, Cheadle WG. Systemic inflammation after trauma. Injury. 2007;38:1336-1345.
4. Cho TJ, Gerstenfeld LC, Einhorn TA. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res. 2002;17:513-520.
5. Swirski FK, Nahrendorf M, Etzrodt M, et al. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009;325:612-616.
6. Kuziel WA, Morgan SJ, Dawson TC, et al. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in cc chemokine receptor 2. Proc Natl Acad Sci\USA. 1997;94:12053-12058.
7. Tsou CL, Peters W, Si Y, et al. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest. 2007;117:902-909.
8. Xie C, Ming X, Wang Q, et al. COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing. Bone. 2008;43:1075-1083.
9. Granero-Molto F, Weis JA, Miga MI, et al. Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells. 2009;27:1887-1898.
10. Gerstenfeld LC, Cho TJ, Kon T, et al. Impaired fracture healing in the absence of TNF-alpha signaling: The role of TNF-alpha in endochondral cartilage resorption. J Bone Miner Res. 2003;18:1584-1592.
11. Boring L, Gosling J, Chensue SW, et al. Impaired monocyte migration and reduced type 1 (th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J Clin Invest. 1997;100:2552-2561.
12. Bostrom MP. Expression of bone morphogenetic proteins in fracture healing. Clin Orthop Relat Res. 1998;355(Suppl):S116-S123.
13. Schmidt-Bleek K, Schell H, Kolar P, et al. Cellular composition of the initial fracture hematoma compared to a muscle hematoma: a study in sheep. J Orthop Res. 2009;27:1147-1151.
14. Chung HY, Cesari M, Anton S, et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009;8:18-30.
15. Lu C, Miclau T, Hu D, et al. Cellular basis for age-related changes in fracture repair. J Orthop Res. 2005;23:1300-1307.
16. Meyer RA Jr, Tsahakis PJ, Martin DF, et al. Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats. J Orthop Res. 2001;19:428-435.
17. Xing Z, Lu C, Hu D, et al. Rejuvenation of the inflammatory system stimulates fracture repair in aged mice. J Orthop Res. 2010;28: 1000-1006.
18. Colnot C, Thompson Z, Miclau T, et al. Altered fracture repair in the absence of MMP9. Development. 2003;130:4123-4133.
19. Behonick DJ, Xing Z, Lieu S, et al. Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration. PLoS One. 2007;2:e1150.
20. Thompson Z, Miclau T, Hu D, et al. A model for intramembranous ossification during fracture healing. J Orthop Res. 2002;20:1091-1098.
21. Parfitt AM. The mechanism of coupling: a role for the vasculature. Bone. 2000;26:319-323.
22. Gerstenfeld LC, Thiede M, Seibert K, et al. Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs. J Orthop Res. 2003;21:670-675.
23. Simon AM, O'Connor JP. Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Joint Surg Am. 2007;89:500-511.
24. Zhang X, Schwarz EM, Young DA, et al. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest. 2002;109:1405-1415.
25. Wixted JJ, Fanning PJ, Gaur T, et al. Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl lt-1 receptor. J Cell Physiol. 2009;221:31-39.
26. Burd TA, Lowry KJ, Anglen JO. Indomethacin compared with localized irradiation for the prevention of heterotopic ossification following surgical treatment of acetabular fractures. J Bone Joint Surg Am. 2001;83:1783-1788.
27. Bhattacharyya T, Levin R, Vrahas MS, et al. Nonsteroidal antiinflamma-tory drugs and nonunion of humeral shaft fractures. Arthritis Rheum. 2005;53:364-367.
28. Gerstenfeld LC, Al-Ghawas M, Alkhiary YM, et al. Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment. J Bone Joint Surg Am. 2007;89:114-125.
29. Tsukamoto T, Chanthaphavong RS, Pape HC. Current theories on the pathophysiology of multiple organ failure after trauma. Injury. 2010; 41:21-26.
30. Keel M, Trentz O. Pathophysiology of polytrauma. Injury. 2005;36:691-709.