Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: A novel role of the cysteinyl IL-1 receptor

Journal of Cellular Physiology

Volumn 221, Issue 1, 2009, Pages 31-39

  Wixted, John J ^a,b   Fanning, Paul J ^a   Gaur, Tripti ^a   O'Connell, Shannon L ^a   Silva, Jason ^a   Mason Savas, April ^a   Ayers, David C ^a   Stein, Gary S ^a   Lian, Jane B ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CYSTEINYLLEUKOTRIENE TYPE 1 RECEPTOR; LEUKOTRIENE RECEPTOR; MONTELUKAST; UNCLASSIFIED DRUG; ZILEUTON; ACETIC ACID DERIVATIVE; DRUG DERIVATIVE; HYDROXYUREA; LEUKOTRIENE B4; LEUKOTRIENE D4 RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; QUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE RADIOGRAPHY; CARTILAGE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENCHONDRAL OSSIFICATION; FEMUR FRACTURE; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MORPHOMETRICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; TREATMENT RESPONSE; ANIMAL; BIOLOGICAL MODEL; BONE DEVELOPMENT; ENZYMOLOGY; FRACTURE; FRACTURE HEALING; GENE EXPRESSION REGULATION; HYPERTROPHY; METABOLISM; PATHOLOGY; RADIOGRAPHY;

ANIMALIA; MUS;

ACETATES; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; CELL PROLIFERATION; CHONDROCYTES; FRACTURE HEALING; FRACTURES, BONE; GENE EXPRESSION REGULATION; HYDROXYUREA; HYPERTROPHY; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENE B4; MICE; MODELS, BIOLOGICAL; OSTEOGENESIS; QUINOLINES; RECEPTORS, LEUKOTRIENE;

EID: 69249228678     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21809     Document Type: Article

References (19)

1. Anon. 1978. International nomenclature of constitutional diseases of bone. Revision, May, 1977. Am J Roentgenol 131:352-354.
2. Akino K, Mineda T, Mori N, Hirano A, Imaizumi T, Akita S. 2006. Attenuation of cysteinyl leukotrienes induces human mesenchymal stem cell differentiation. Wound Repair Regen 14:343-349.
3. Beck A, Krischak G, Sorg T, Augat P, Farker K, Merkel U, Kinzl L, Claes L. 2003. Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing. Arch Orthop Trauma Surg 123:327-332.
4. Bergenstock M, Min W, Simon AM, Sabatino C, O'Connor JP. 2005. A comparison between the effects of acetaminophen and celecoxib on bone fracture healing in rats. J Orthop Trauma 19:717-723.
5. Boyce JA. 2008. Eicosanoids in asthma, allergic inflammation, and host defense. Curr Mol Med 8:335-349.
6. Denzlinger C, Rapp S, Hagmann W, Keppler D. 1985. Leukotrienes as mediators in tissue trauma. Science 230:330-332.
7. Einhorn TA. 2005. The science of fracture healing. J Orthop Trauma 19:S4-S6.
8. Engesaeter LB, Sudmann B, Sudmann E. 1992. Fracture healing in rats inhibited by locally administered indomethacin. Acta Orthop Scand 63:330-333.
9. Gerstenfeld LC, Wronski TJ, Hollinger JO, Einhorn TA. 2005. Application of histomorphometric methods to the study of bone repair. J Bone Miner Res 20:1715-1722.
10. Gerstenfeld LC, Al-Ghawas M, Alkhiary YM, Cullinane DM, Krall EA, Fitch JL, Webb EG, Thiede MA, Einhorn TA. 2007. Selective and nonselective cyclooxygenase-2 inhibitors and experimental fracture-healing. Reversibility of effects after short-term treatment. J Bone Joint Surg Am 89:114-125.
11. Hogevold HE, Grogaard B, Reikeras O. 1992. Effects of short-term treatment with corticosteroids and indomethacin on bone healing. A mechanical study of osteotomies in rats. Acta Orthop Scand 63:607-611.
12. Keller J, Bayer-Kristensen I, Bak B, Bunger C, Kjaersgaard-Andersen P, Lucht U, Melsen F. 1989. Indomethacin and bone remodeling. Effect on cortical bone after osteotomy in rabbits. Acta Orthop Scand 60:119-121.
13. Manigrasso MB, O'Connor JP. 2006. Accelerating fracture healing by manipulating arachidonic acid metabolism. ORS 31:0070.
14. Marturano JE, Cleveland BC, Byrne MA, O'Connell SL, Wixted JJ, Billiar KL. 2008. An improved murine femur fracture device for bone healing studies. J Biomech 41:1222-1228.
15. Murnaghan M, Li G, Marsh DR. 2006. Nonsteroidal anti-inflammatory drug-induced fracture nonunion: An inhibition of angiogenesis? J Bone Joint Surg Am 88:140-147.
16. Schindeler A, McDonald MM, Bokko P, Little DG. 2008. Bone remodeling during fracture repair: The cellular picture. Semin Cell Dev Biol 19:459-466.
17. Simon AM, O'Connor JP. 2007. Dose and time-dependent effects of cyclooxygenase-2 inhibition on fracture-healing. J Bone Joint Surg Am 89:500-511.
18. Sudmann E, Dregelid E, Bessesen A, Morland J. 1979. Inhibition of fracture healing by indomethacin in rats. Eur J Clin Invest 9:333-339.
19. Traianedes K, Dallas MR, Garrett IR, Mundy GR, Bonewald LF. 1998. 5-Lipoxygenase metabolites inhibit bone formation in vitro. Endocrinology 139:3178-3184.