Mechanism of substrate shuttling by the Acyl-carrier protein within the fatty acid mega-synthase

Journal of the American Chemical Society

Volumn 132, Issue 35, 2010, Pages 12357-12364

  Anselmi, Claudio ^a   Grininger, Martin ^a   Gipson, Preeti ^b   Faraldo Goěmez, Josě D ^a,c  

^a MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c Cluster of Excellence Macromolecular Complexes   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC CHAINS; CARRIER PROTEINS; CATALYTIC CENTER; CATALYTIC SITES; CHAMBER WALLS; ENERGETIC FACTORS; MOLECULAR CROWDING; REACTION CHAMBERS; SIMULATION STUDIES; SPATIAL DISTRIBUTION; STERIC HINDRANCES; SYNTHASES; SYSTEMATIC ASSESSMENT;

ACIDS; COMPUTER SIMULATION; FATTY ACIDS; SCAFFOLDS; SIZE DISTRIBUTION; SUBSTRATES;

PROTEINS;

ACYL CARRIER PROTEIN; FATTY ACID SYNTHASE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; ELASTICITY; ENTROPY; FUNGUS; NONHUMAN; SIMULATION; STOCHASTIC MODEL; X RAY CRYSTALLOGRAPHY;

ACYL CARRIER PROTEIN; BIOCATALYSIS; COMPUTER SIMULATION; FATTY ACID SYNTHETASE COMPLEX; MODELS, MOLECULAR; THERMODYNAMICS;

EID: 77956238178     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja103354w     Document Type: Article

References (27)

1. Lynen, F. Eur. J. Biochem. 1980, 112, 431-442
2. Lomakin, I. B., Xiong, Y., and Steitz, T. A. Cell 2007, 129, 319-332
3. Jenni, S., Leibundgut, M., Maier, T., and Ban, N. Science 2006, 311, 1263-1267
4. Jenni, S., Leibundgut, M., Boehringer, D., Frick, C., Mikolasek, B., and Ban, N. Science 2007, 316, 254-261
5. Leibundgut, M., Jenni, S., Frick, C., and Ban, N. Science 2007, 316, 288-290
6. Leibundgut, M., Maier, T., Jenni, S., and Ban, N. Curr. Opin. Struct. Biol. 2008, 18, 714-725
7. Johansson, P., Wiltschi, B., Kumari, P., Kessler, B., Vonrhein, C., Vonck, J., Oesterhelt, D., and Grininger, M. Proc. Natl. Acad. Sci. U.S.A 2008, 105, 12803-12808
8. Gipson, P., Mills, D. J., Wouts, R., Grininger, M., Vonck, J., and Kuhlbrandt, W. Proc. Natl. Acad. Sci. U.S.A 2010, 107, 9164-9169
9. Campbell, J. W. and Cronan, J. E., Jr. Annu. Rev. Microbiol. 2001, 55, 305-332
10. White, S. W., Zheng, J., Zhang, Y. M., and Rock, C. O. Annu. Rev. Biochem. 2005, 74, 791-831
11. Šali, A. and Blundell, T. L. J. Mol. Biol. 1993, 234, 779-815
12. Berendsen, H. J. C., van der Spoel, D., and van Drunen, R. Comput. Phys. Commun. 1995, 91, 43-56
13. Hess, B., Bekker, H., Berendsen, H. J. C., and Fraaije, J. G. E. M. J. Comput. Chem. 1997, 18, 1463-1472
14. Marrink, S. J., Risselada, H. J., Yefimov, S., Tieleman, D. P., and de Vries, A. H. J. Phys. Chem. B 2007, 111, 7812-7824
15. Monticelli, L., Kandasamy, S. K., Periole, X., Larson, R. G., Tieleman, D. P., and Marrink, S. J. J. Chem. Theory Comput. 2008, 4, 819-834
16. Humphrey, W., Dalke, A., and Schulten, K. J. Mol. Graph. 1996, 14, 33-38
17. Sarkar, A., Caamano, S., and Fernandez, J. M. J. Biol. Chem. 2005, 280, 6261-6264
18. Li, H., Oberhauser, A. F., Redick, S. D., Carrion-Vazquez, M., Erickson, H. P., and Fernandez, J. M. Proc. Natl. Acad. Sci. U.S.A 2001, 98, 10682-10686
19. Kratky, O. and Porod, G. Rev. Trav. Chim. Pays-Bas 1949, 68, 1106-1123
20. Parris, K. D., Lin, L., Tam, A., Mathew, R., Hixon, J., Stahl, M., Fritz, C. C., Seehra, J., and Somers, W. S. Structure. 2000, 8, 883-895
21. Zhang, Y. M., Rao, M. S., Heath, R. J., Price, A. C., Olson, A. J., Rock, C. O., and White, S. W. J. Biol. Chem. 2001, 276, 8231-8238
22. Zhang, Y. M., Wu, B., Zheng, J., and Rock, C. O. J. Biol. Chem. 2003, 278, 52935-52943
23. Zhang, Y. M., Marrakchi, H., White, S. W., and Rock, C. O. J. Lipid Res. 2003, 44, 1-10
24. Rafi, S., Novichenok, P., Kolappan, S., Zhang, X., Stratton, C. F., Rawat, R., Kisker, C., Simmerling, C., and Tonge, P. J. J. Biol. Chem. 2006, 281, 39285-39293
25. Roujeinikova, A., Simon, W. J., Gilroy, J., Rice, D. W., Rafferty, J. B., and Slabas, A. R. J. Mol. Biol. 2007, 365, 135-145
26. Shen, B. Curr. Opin. Chem. Biol 2003, 7, 285-295
27. Walsh, C. T. Acc. Chem. Res. 2008, 41, 4-10