Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom

Biologicals

Volumn 38, Issue 5, 2010, Pages 577-585

  Solano, Gabriela ^a   Segura, Álvaro ^a   Herrera, María ^a   Gómez, Aarón ^a   Villalta, Mauren ^a   Gutiérrez, José María ^a   León, Guillermo ^a  

^a UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

Antivenom potency; Biological assay; Bothrops asper; ED50; LD50; Lethality; Lethality neutralization assay; Median effective dose; Median lethal dose; Snake venom

Indexed keywords

SNAKE VENOM; SNAKE VENOM ANTISERUM;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG POTENCY; DRUG SCREENING; FEMALE; INCUBATION TIME; LD 50; LETHALITY NEUTRALIZATION ASSAY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SNAKE;

ANIMALS; ANTIVENINS; BOTHROPS; CROTALID VENOMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LETHAL DOSE 50; LIMIT OF DETECTION; MALE; MICE; NEUTRALIZATION TESTS; RESEARCH DESIGN; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

ANIMALIA; BOTHROPS ASPER; MUS;

EID: 77956226933     PISSN: 10451056     EISSN: 10958320     Source Type: Journal    
DOI: 10.1016/j.biologicals.2010.05.006     Document Type: Article

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