Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: Understanding the role of metalloproteinases in envenomation

Toxicon

Volumn 43, Issue 4, 2004, Pages 417-424

  Rucavado, Alexandra ^a   Escalante, Teresa ^a   Gutiérrez, José María ^a  

^a UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

Batimastat; Hemorrhage; Metalloproteinase; Peptidomimetic hydroxamates; Snake venom

Indexed keywords

BATIMASTAT; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; SERINE PROTEINASE; SNAKE VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; BOTHROPS ASPER; CENTRAL AMERICA; CONTROLLED STUDY; DOSE RESPONSE; ENVENOMATION; EXPERIMENTAL MOUSE; IN VITRO STUDY; IN VIVO STUDY; LD 50; LETHALITY; LUNG HEMORRHAGE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROVOCATION TEST; SNAKE; STATISTICAL SIGNIFICANCE; TIME OF DEATH; TOXICITY;

ANIMALS; BLOOD COAGULATION; BOTHROPS; COSTA RICA; CROTALID VENOMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FACTOR X; HEMORRHAGE; HISTOLOGICAL TECHNIQUES; LETHAL DOSE 50; LUNG; METALLOENDOPEPTIDASES; MICE; PHENYLALANINE; PROTHROMBIN; SNAKE BITES; THIOPHENES; TIME FACTORS;

BOTHROPS; BOTHROPS ASPER; SERPENTES;

EID: 1642462834     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2004.01.016     Document Type: Article

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