Effectiveness of snake antivenom: Species and regional venom variation and its clinical impact

Journal of Toxicology - Toxin Reviews

Volumn 22, Issue 1, 2003, Pages 23-34

  Fry, Bryan G ^a,b   Winkel, Kenneth D ^a   Wickramaratna, Janith C ^c   Hodgson, Wayne C ^c   Wüster, Wolfgang ^d  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c MONASH UNIVERSITY   (Australia)

^d BANGOR UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SNAKE VENOM; SNAKE VENOM ANTISERUM;

BLEEDING; DRUG EFFICACY; DRUG INDUSTRY; DRUG MANUFACTURE; HUMAN; LETHAL DOSE; NECROSIS; REVIEW; SNAKEBITE; SPECIES; TREATMENT FAILURE;

SERPENTES;

EID: 0037237225     PISSN: 07313837     EISSN: None     Source Type: Journal    
DOI: 10.1081/TXR-120019018     Document Type: Review

References (59)

1. Afifiyan, F., Armugam, A., Tan, C. H., Gopalakrishnakone, P., Jeyaseelan, K. (Mar. 1999). Postsynaptic alpha-neurotoxin gene of the spitting cobra, Naja naja sputatrix: structure, organization, and phylogenetic analysis. Genome Res. 9(3):259-266.
2. Assakura, M. T., Furtado, M. F. D., Mandelbaum, F. R. (1992). Biochemical and biological differentiation of the venoms of the lancehead vipers (Bothrops atrox, Bothrops asper, Bothrops marajoensis and Bothrops moojeni). Comp. Biochem. Physiol., B, Comp. Chem. 102:727-732.
3. Barchan, D., Kachalsky, S., Neumann, D., Vogel, Z., Ovadia, M., Kochva, E., Fuchs, S. (Aug. 15, 1992). How the mongoose can fight the snake: the binding site of the mongoose acetylcholine receptor. Proc. Natl. Acad. Sci. U. S. A. 89(16):7717-7721.
4. Barfaraz, A., Harvey, A. L. (1994). The use of the chick biventer cervicis preparation to assess the protective activity of six international reference antivenoms on the neuromuscular effects of snake venoms in vitro. Toxicon 32:267-272.
5. Brazil, V. (1901). Contribuição ao estudo de veneno ophídico. III. Tratamentos das mordeduras das cobras. Rev. Med. (São Paulo) 4:375-380.
6. Calmette, A. (1894). Propriétés du sérum des animaux immunisés contre le venin des serpents; thérapeutique de l'envenimation. C. R. Hebd. Seances Acad. Sci., Paris 118:720-722.
7. Calmette, A. Venoms, Venomous Animals and Serotherapy. Paris: Masson, (French Ed. 1907).
8. Chang, L., Lin, S., Huang, H., Hsiao, M. (Oct. 15, 1999). Genetic organization of alpha-bungarotoxins from Bungarus multicinctus (Taiwan banded krait): evidence showing that the production of alpha-bungarotoxin isotoxins is not derived from edited mRNAs. Nucleic Acids Res. 27(20):3970-3975.
9. Cheng, A. C., Winkel, K. D. (2001a). Call for global snakebite control and procurement funding. Lancet 357:1132.
10. Cheng, A. C., Winkel, K. D. (2001b). Snakebite and antivenoms in the Asia-Pacific: Wokabaut wantaim - raka hebou ("walking together"). Med. J. Aust. 175:648-651.
11. Chippaux, J.-P. (1998). Snake bites: appraisal of the global situation. Bull. W.H.O. 76:515-524.
12. Chippaux, J. P., Goyffon, M. (1998). Venoms, antivenoms and immunotherapy. Toxicon 36:823-846.
13. Crachi, M. T., Hammer, L. W., Hodgson, W. C. (1999). The effects of antivenom on the in vitro neurotoxicity of venoms from the taipans Oxyuranus scutellatus, Oxyuranus microlepidotus and Oxyuranus scutellatus canni. Toxicon 37:1771-1778.
14. Daltry, J. C., Wüster, W., Thorpe, R. S. (1996). Diet and snake venom evolution. Nature 379:537-540.
15. Frazer, T. R. (1895). The rendering of animals immune against the venom of the cobra and other serpents and the antidotal properties of the blood serum of immunised animals. Br. Med. J. 1:1309-1312.
16. Fry, B. G., Wickramaratna, J. C., Jones, A., Alewood, P. F., Hodgson, W. C. (2001). Species and regional variations in the effectiveness of antivenom against the in vitro neurotoxicity of death adder (Acanthophis) venoms. Toxicol. Appl. Pharmacol. 175:140-148.
17. Fry, B. G., Wickramaratna, J. C., Hodgson, W. C., Alewood, P. F., Kini, R. M., Ho, H., Wüster, W. (Mar. 30, 2002). Electrospray liquid chromatography/mass spectrometry fingerprinting of Acanthophis (death adder) venoms: taxonomic and toxinological implications. Rapid Commun. Mass Spectrom. 16(6):600-608.
18. Galli, R. (2001). The antivenin is safe, but its future is uncertain. West. J. Med. 175:91-92.
19. Gillissen, A., Theakston, R. D., Barth, J., May, B., Krieg, M., Warrell, D. A. (1994). Neurotoxicity, haemostatic disturbances and haemolytic anaemia after a bite by a Tunisian saw-scaled or carpet viper (Echis 'pyramidum'-complex): failure of antivenom treatment. Toxicon 32:937-944.
20. Glenn, J. L., Straight, R. C., Wolfe, M. C., Hardy, D. L. (1983). Geographical variation in Crotalus scutulatus scutulatus (Mojave rattlesnake) venom properties. Toxicon 21:119-130.
21. Gutiérrez, J. M., Rojas, G., Lomonte, B., Gene, J. A., Chaves, F., Alvarado, J., Rojas, E. (1990). Standardization of assays for testing the neutralizing ability of antivenoms. Toxicon 28:1127-1129.
22. Hawgood, B. (1992). Pioneers of antivenomous serotherapy: Dr. Vital Brazil (1865-1950). Toxicon 30:573-579.
23. Heatwole, H., Poran, N. S. (1995). Resistances of sympatric and allopatric eels to sea snake venoms. Copeia 1995:136-147.
24. Henderson, A., Baldwin, L. N., May, C. (1993). Fatal brown snake (Pseudonaja textilis) envenomation despite the use of antivenom. Med. J. Aust. 158:709-710.
25. Jiménez-Porras, J. M. (1964). Venom proteins of the fer-de-lance Bothrops atrox from Costa Rica. Toxicon 2:155-166.
26. Kordiš, D., Gubenšek, F. (2000). Adaptive evolution of animal toxin multigene families. Gene 261:43-52.
27. Lamb, G. (1904). On the serum therapeutics of cases of snake bite. Lancet ii:1273-1277.
28. Looareesuwan, S., Viravan, C., Warrell, D. A. (1988). Factors contributing to fatal snake bite in the tropics: analysis of 46 cases in Thailand. Trans. R. Soc. Trop. Med. Hyg. 82:930-934.
29. Martin, C. J. (1897). The curative value of Calmette's antivenomous serum in the treatment of innoculations with the poisons of Australian snakes. Intercoloni. Med. J. Aust. 2:527-536.
30. Masci, P. P., Mirtschin, P. J., Nias, T. N., Turnbull, R. K., Kuchel, T. R., Whitaker, A. N. (1998). Brown snakes (Pseudonaja genus): venom yields, prothrombin activator neutralisation and implications affecting antivenom usage. Anaesth. Intensive Care 26:276-281.
31. McNamee, D. (2001). Tackling venomous snake bites worldwide. Lancet 357:1680.
32. Mebs, D., Kornalík, F. (1981). Schlangengiftseren - Probleme ihrer Wirksamkeit, untersucht am Beispiel von Echis carinatus. Salamandra 17:89-98.
33. Phisalix, C., Bertrand, G. (1894). Sur la propriété antitoxique du sang des animaux vaccinés contre le venin de vipère. C. R. Soc. Biol. 46:111-114.
34. Poran, N. S., Coss, R. G., Benjamini, E. (1987). Resistance of California ground squirrels (Spermophilus beecheyi) to the venom of the northern Pacific rattlesnake (Crotalus viridis oreganus): a study of adaptive variation. Toxicon 25:767-777.
35. Russell, F. E. (1988). Snake venom immunology: historical and practical considerations. J. Toxicol., Toxin Rev. 7:1-82.
36. Scholtz, M. (1999). WHO's role in ensuring access to essential drugs. W.H.O. Drug Inf. 13:217-220.
37. 50) using fertile hens' eggs. Toxicon 39:665-668.
38. Slowinski, J. B., Knight, A., Rooney, A. P. (1997). Inferring species trees from gene trees: a phylogenetic analysis of the Elapids (Serpentes) based on amino acid sequences of venom proteins. Mol. Phylogenet. Evol. 8:349-362.
39. Sprivulus, P., Jelinek, G. A., Marshall, I. (1996). Efficacy and potency of antivenoms in neutralising the procoagulant effects of Australian snake venoms in dog and human plasma. Anaesth. Intensive Care 24:379-381.
40. Sutherland, S. K., Leonard, R. (1995). Snake bite deaths in Australia 1992-1994 and a management update. Med. J. Aust. 163:616-618.
41. Sutherland, S. K., Tibballs, J. (2001). Chapter 7. Genus Pseudonaja, brown snakes. Australian animal toxins. In: The Creatures, Their Toxins and the Care of the Poisoned Patient. Melbourne, Australia: Oxford University Press, p. 108.
42. Theakston, R. D. G., Reid, H. A. (1983). Development of simple standard assay procedures for the characterization of snake venoms. Bull. W.H.O. 61:949-956.
43. Theakston, R. D. G., Warrell, D. A. (2000). Crisis in snake antivenom supply for Africa. Lancet 356:2104.
44. Tibballs, J., Sutherland, S. K. (1991). The efficacy of antivenom in the prevention of cardiovascular depression and coagulopathy induced by brown snake (Pseudonaja) species venom. Anaesth. Intensive Care 19:530-534.
45. Tidswell, F. (1902). A preliminary note on the serum-therapy of snake bite. Australas. Med. Gaz. 21:177-181.
46. Trevan, J. W. (1927). The error of determination of toxicity. Proc. R. Soc. 101B:483.
47. Trinca, J. C. (1969). Report of recovery from a taipan bite. Med. J. Aust. 1:514-516.
48. Viravan, C., Looareesuwan, S., Kosakarn, W., Wuthiekanun, V., McCarthy, C. J., Stimson, A. F., Bunnag, D., Harinasuta, T., Warrell, D. A. (1992). A national hospital-based survey of snakes responsible for bites in Thailand. Trans. R. Soc. Trop. Med. Hyg. 86:100-106.
49. Vogtman, D. B. (1950). The relative efficiency of two types of antivenom sera in neutralizing cobra venom. Copeia 1950:177-181.
50. Warrell, D. A. (1986). Tropical snake bite: clinical studies in south-east Asia. In: Harris, J. B., ed. Natural Toxins - Animal, Plant and Microbial. Oxford: Clarendon Press. pp. 25-45.
51. Warrell, D. A. (1989). Snake venoms in science and clinical medicine 1. Russell's viper: biology, venom and treatment of bites. Trans. R. Soc. Trop. Med. Hyg. 83:732-740.
52. Warrell, D. A. (1999). WHO/SEARO guidelines for the clinical management of snake bites in the Southeast Asian region. Southeast Asian J. Trop. Med. Public Health 30(Suppl. 1):1-85.
53. Warrell, D. A., Arnett, C. (1976). The importance of bites by the saw-scaled or carpet viper (Echis carinatus): epidemiological studies in Nigeria and a review of the world literature. Acta Trop. 33:307-341.
54. World Health Organisation Publishing, Geneva. (1981). Progress in the Characterization of Venom and Standardization of Antivenoms, W.H.O. Offset Publ., pp. 58, 44.
55. Wilkinson, J. A., Glenn, J. L., Straight, R. C., Sites, J. W., Jr. (1991). Distribution and genetic variation in venom A and venom B populations of the Mojave rattlesnake (Crotalus scutulatus scutulatus) in Arizona. Herpetologica 47:54-68.
56. Winkel, K. D., Rinauldo, M., Fry, B. G., Hawdon, G. M., Carroll, T. (2001). Black snake, brown snake or mistake? A cautionary tale. Aust. Fam. Physician 30:832.
57. Wüster, W., McCarthy, C. J. (1996). Venomous snake systematics: implications for snake bite treatment and toxinology. In: Bon, C., Goyffon, M., eds. Envenomings and Their Treatments. Lyon: Fondation Marcel Mérieux, pp. 13-23.
58. Wüster, W., Otsuka, S., Malhotra, A., Thorpe, R. S. (1992). Population systematics of Russell's viper: a multivariate study. Biol. J. Linn. Soc. 47:97-113.
59. Yang, C. C., Chang, L. S., Wu, F. S. (1991). Venom constituents of Notechis scutatus scutatus (Australian tiger snake) from differing geographic regions. Toxicon 29(11):1337-1344.